98results about How to "Effective therapeutic effect" patented technology

The invention discloses a medicinal balloon catheter and a preparation method thereof. The balloon outside surface of the medicinal balloon catheter is grinded and processed through ultraviolet laser to form the concave-convex non-planar structure on the balloon outside surface. The gaps within the non-planar structure form a drug storage layer. The wavelength of the ultraviolet laser is within the range of 10-400nm. The wall thickness of the medicinal balloon catheter is 15-25 microns. The thickness of the non-planar structure is 8-12 microns. Owning to the concave-convex non-planar structure of the balloon outside surface of the medicinal balloon catheter in the invention, the medicinal adsorption storage capacity is fundamentally improved, namely firstly, the amount of the adsorbed medicine is greatly increased, secondly when medicine adsorbed on balloon passes through blood vessels to reach the site of lesion, the medicine adsorbed on the outer wall of the balloon can be maintained as much as possible and cannot be washed off by blood in the blood vessels and cause loss, and can be effectively transferred to the site of lesion by the balloon so as to have effectively therapeutic action. The medicinal balloon catheter of the invention can be used in not only coronary heart disease, but also various diseases caused by other narrow vessels such as lower extremity arterial stenos is or occlusion caused by diabetes.

The present invention discloses a new precursor miRNA and applications of the new precursor miRNA in tumor treatment. Specifically the present invention provides a precursor miRNA, wherein the structure represented by a formula I exists at the 5' to 3' terminal, B1 is anti-miRNA-214-5p, B2 is a sequence substantially complementary or completely complementary to B1, B2 and C are not complementary, C is a stem-loop structural sequence, A1 and A2 respectively are none, optionally RNA sequences comprising 4-5 bases, the precursor miRNA can be processed in a host to form anti-miRNA-214, and in the anti-miRNA-214, only the anti-miRNA-214-5p is expressed while the anti-miRNA-214-3p is not expressed. The formula I is defined in the specification.

A novel derivative of combretastatins which has water solubility and is capable of releasing the drug independent of biological enzymes likely to cause individual differences and whose effective therapeutic effect can be expected has been demanded. A high-molecular weight conjugate of combretastatins, characterized by having a structure in which a hydroxyl group of a combretastatin is linked via an ester bond to a carboxylic acid group of the polymer moiety in a block copolymer of a polyethylene glycol moiety with the polymer moiety having two or more carboxylic acid groups such as polyaspartic acid or polyglutamic acid is provided.

The present invention relates to an immunoliposome preparation having a therapeutic effect on cancer, autoimmune disease, or inflammatory disease. Specifically, the present invention relates to an immunoliposome comprising, as a constituent, an antibody capable of inducing the apoptosis of cells expressing a death domain-containing receptor.

The invention relates to a biological active peptide modified nano-silver, wherein the biological active peptide is mercapto cell-penetrating peptide, and the biological active peptide modified nano-silver is formed by covalently connecting the mercapto cell-penetrating peptide to the surface of AgNP through Ag-S bonds. The biological active peptide modified nano-silver provided by the invention not only realizes an ability of an inorganic nano material AgNP penetrating a cell membrane, thereby greatly improving the inhibition effect on the growth of tumor cells, but also finds a new potential drug for tumor treatment.

The invention belongs to the field of medicinal preparations and in particular relates to a Dasatinib dispersoid, a preparation method thereof and an application thereof in preparation of Dasatinib dispersible tablets. Dasatinib solid dispersoid is prepared by using Dasatinib as an active ingredient and is prepared into tablets of different specifications. The Dasatinib solid dispersible tablets overcome the defects of incomplete release of the medicine and low bioavailability caused by that the dispersible common oral tablets are easy to adhere in the medicine releasing process, so that the bioavailability of the Dasatinib medicine can be further improved and the therapeutic effect of the medicine can be effectively exerted. The preparation process is simple, convenient and practical.

The invention discloses a traditional Chinese medicine and tea brewing potus for treating acute or chronic faucitis. The traditional Chinese medicine and tea brewing potus is characterized by being mainly prepared from the following active pharmaceutical ingredients in part by weight: 2-5 parts of dried rhizome of rehmannia, 2-6 parts of figwort root, 2-6 part of honeysuckle flower, 1-3 parts of periostracum cicada, 2-4 parts of root of straight ladybell, 2-5 parts of platycodon root, 2-4 parts of dwarf lilyturf root, 2-6 parts of Indian trumpetflower seed and 2-6 parts of fructus mume. The tea brewing potus disclosed by the invention is prepared by respectively splitting various medicines into sheets or fine sections and mixing; 30-60g of potus is brewed with boiled water for 20-40 minutes and drunk each time and can be continuously brewed with boiled water for 5-8 times and drunk, wherein decoction dredges are discarded. The traditional Chinese medicine and tea brewing potus has the functions of clearing away heat and toxic materiasl, nourishing yin and moisturizing the lung, promoting the production of body fluid and relieving sore throat and the like and is used for treating the acute or chronic faucitis.

The invention discloses hydrogel for repairing injured tissue and a preparation method thereof. The preparation method comprises the following steps: dissolving a hydrogel material through sterile distilled water, and swelling to obtain hydrogel; dissolving PGE2 powder into a phosphate buffering solution to prepare a PGE2 solution; dropwise adding the PGE2 solution into the hydrogel; stirring for 3-5 hours under the temperature of 2-8 DEG C; storing or storing by freezing, wherein the PGE2 is the abbreviation of prostaglandin E2. With the adoption of the hydrogel, the release time of PGE2 can be certainly prolonged; the hydrogel is directly applicable to the treatment of tissue injury, and is capable of promoting the recovery of injured skin tissue and function; the hydrogel is capable of inducing macrophage at the injured site to polarize to reach M2 type so as to inhibit inflammatory, thereby accelerating the healing of the injured tissue; in addition, the blood vessel at the injured part is promoted to regrow in early stage. Additionally, the hydrogel is free from cytotoxicity, can directly coat the surface of the injured tissue, is convenient to use, and low in price, and has an effective treatment effect.

The invention discloses a siRNA inhibiting EGFR expression as well as precursor sequence and an application of siRNA. The EGFR siRNA can highly inhibit EGFR gene expression, and an in-vivo experimentshows that the EGFR siRNA has a certain inhibition effect on EGER tumors with high expression. The precursors and carriers of siRNA can form stable siRNA in a host and come into effect.

The invention discloses a built-in bone support device. In the built-in bone support device, the edge of a circular top disc is provided with a cylindrical side wall which is extended outward; and the middle part of the cylindrical side wall is provided with longitudinal grids which are distributed uniformly. The designed support device can be used for treating large-area osteonecrosis and bone collapses caused by the large-area osteonecrosis, and achieves the effects of easing pain, repairing the inner structure of a femoral head, and recovering the femoral head. The built-in bone support device can only be used for treating femoral head necrosis and can also be used for treating osteonecrosis of other parts.

The invention relates to insulin-like growth factor C (IGF-1C) structural domain polypeptide combined chitosan hydrogel, which has high cytocompatibility and biological activity. The active hydrogel has injectability and can serve as a carrier material to promote the treatment effect of the stem cells in tissue damage. A proper tissue regeneration micro-environment is provided for stem cell transplantation, so that the survival rate of the transplanted stem cells is increased. Survival and retention of the stem cells in the damage area are enhanced, survival and proliferation of the transplanted cells are promoted, apoptosis is reduced, and angiogenesis and functional recovery of the damage part are promoted, so that the treatment effect of stem cell transplantation on tissue damage is improved. In addition, the hydrogel after transplantation does not promote poor differentiation of the stem cells.

The invention discloses compound creat injection used for treating hyperpyrexia of a pig and a preparation method thereof, aiming to provide the compound creat injection for treating the hyperpyrexia of the pig with small side effect and the preparation method thereof with the advantages of simple technique and easy realization. Each 100 liters of the injection is prepared by the following raw materials: 50 to 150 kilograms of creat, 0.5 to 5 kilograms of zedoary turmeric oil, 50 to 150 kilograms of Chinese thorowax, 30 to 80 kilograms of garlic, 0.5 kilograms of tween-80, 0.9 kilograms of sodium chloride, 100 kilograms of 95 percent ethanol, the balance being injection water. The compound creat injection is formed by the creat and three traditional Chinese medicines including the Chinese thorowax , the zedoary turmeric oil and the garlic, has the efficacies of antivirus, antibacteria, fever reduction and improvement of the immunity of an organism through reasonable determination of the content of various compositions, strengthens intrinsic phagocytic function, is effective to drug-resistant pathogen of western medicines and the hyperpyrexia of the pig, and relieves the stress reaction of the pig. Simultaneously, the product is traditional Chinese medicine preparation, has small side effect, does not aggravate the burden of the liver and the kidney, and can effectively treat an illness.

The present invention discloses a medicinal bait additive for preventing and treating enterocytozoon hepatopenaei of litopenaeus vannamei. The medicinal bait additive comprises the following components in parts by weight: 8-32 parts of marine red yeast powder, 30-75 parts of albendazole, 8-32 parts of spirulina powder and 5-10 parts of garlic powder. The medicinal bait additive is used in a compound feed for the litopenaeus vannamei and has an addition amount of only 6-12%; and the medicinal bait additive can also be mixed with the feed at a weight ratio of 1:10 for feeding before feeding. Themedicinal bait additive uses an internal administration route, so that a medicine internal environment is formed in a host body, the medicinal bait additive is subjected to blood circulation to reachtarget organs and parasites cannot survive. The medicinal bait additive can effectively kill the enterocytozoon hepatopenaei in the litopenaeus vannamei body, is non-toxic to the litopenaeus vannameibody, does not cause medicine residues in the litopenaeus vannamei body, at the same time also does not cause pollution to the breeding environment, and can effectively play a therapeutic role in thediseased litopenaeus vannamei infected by the enterocytozoon hepatopenaei.

The invention relates to a pharmaceutical composition for reducing homocysteine, which comprises the following components: 1) an officinal dosage of folic acid or pharmaceutical salts thereof; 2) an officinal dosage of vitamin B12 or pharmaceutical salts thereof; 3) an officinal dosage of creatine or pharmaceutical salts thereof; and 4) pharmaceutical carriers or excipients. The composition further comprises one or more than one of betaine, VB6, N-acetylcysteine, and riboflavin. The invention also relates to application of the pharmaceutical composition in preparing drugs for reducing the homocysteine as well as the application thereof in preparing the drugs for treating life bodies suffered from hyperhomocysteinemia. The pharmaceutical composition belongs to the field of pharmacy.

The invention discloses a preparation process of a quetiapine fumarate slow release tablet, belonging to the technical field of preparing medicinal slow / controlled-release preparations. In the process, a soluble slow-release accessory is used as a retarding agent, and slow-release particles are prepared by using a fusion-method solid dispersion technology and are tabletted. The quetiapine fumarate slow release tablet is the slow-release matrix tablet prepared by using a process of externally covering the tablet with a quick-release thin-film coating. The quetiapine fumarate in the invention has the in-vitro release characteristics as follows: after 750ml of 0.1NHCl is added for 2 hours, the release amount of quetiapine fumarate within 0-2 hours is 0-35%, and after 250ml of K3PO4 is added, the release amounts of the quetiapine fumarate within 2-8 hours, 8-12 hours and 12-20 hours are respectively 35-60%, 60-80% and 80-100%. The process has the advantages of simple and safe flow, controllable quality, low cost, short production period and great suitability for large-scale industrial production.

A SARS virus antigen-antibody vaccine and its experimented method are disclosed. Said composite vaccine is prepared from the SARS virus antigen and specific antibody, and features that it can directly submit said virus antigen to the antigen presenting APC cells and mononuclear / macrophage for exciting the immune response mechanism of lymphatic immune system. Its advantages are high immune effect and specific target treatment to SARS.

The invention provides a compound traditional Chinese medicine which is externally used for curing uterocarcinoma and process for preparation. The medicine discharges the dead cancer cell organization liquid out of a body and anthracia mechanism through the infiltration function and the function of blocking the existence of cancer cells and killing the target cells of the cancer cells, and simultaneously improves the immune function of a body, and finally achieves the aim of curing uterocarcinoma.

The invention discloses a virulent phage sensitive to riemerella anatipestifer and application thereof. The virulent phage sensitive to riemerella anatipestifer is named RAP37 and is preserved in China General Microbiological Culture Collection Center with preservation date of March-2-2009 and preservation number of CGMCC No.2908, the diameter thereof is about 1-2mm, the periphery is not provided with halo, the phage is composed of one polyhedral head and lathy tail, the face profile of the head is hexagon and the diameter is about 60nm, the tail is about 200nm long and 8nm wide and the genome thereof is double-stranded DNA. The virulent phage sensitive to riemerella anatipestifer is named RAP37, can decompose the riemerella anatipestifer, and can treat and prevent riemerella anatipestifer disease caused by leading pathogen of the riemerella anatipestifer which endangers duck breeding industry by adopting biotherapy.

The aim of the invention is to provide a compound traditional Chinese medicine which is externally used for curing breast cancer and process for preparation. The medicine discharges the dead cancer cell organization out of a body and anthracia mechanism through the infiltration function and the function of blocking the existence of cancer cells and killing the target cells of the cancer cells, and simultaneously improves the immune function of a body, and finally achieves the aim of curing breast cancer.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a triptolide targeting liposome for treating rheumatoid arthritis and a preparation method thereof. The long-circulating targeting liposome is composed of triptolide, a membrane material and a targeting ligand. According to the triptolide long-circulating targeting liposome and the preparation method thereof provided by the invention, the liposome is modified by DSPE-PEG2000 and DSPE-PEG2000-FA to obtain a brand new targeting liposome, and the targeting liposome can enable a drug to target an inflammation part; the triptolide is encapsulated in a hydrophobic bilayer of a biological membrane-like film, thereby better exerting the effects of immunosuppression, inflammation resistance and cartilage tissue protection. The invention provides a new countermeasure for treatment of the rheumatoid arthritis, and has important theoretical significance and clinical significance.

The therapeutic hepatitis B vaccine is liposome containing hepatitis B surface antigen with or without immunoregulation molecule. It may be used to treat chronic hepatitis B caused by HIV infection and to prevent HIV infection. The technological process of inverse phase evaporation and freeze drying to prepare the said vaccine is also provided.

The invention relates to a Chinese medicinal preparation for treating cerebrovascular neuropathic pain. The Chinese medicinal preparation is prepared from the following raw materials in part by weight: 25 to 30 parts of cassia twig, 12 to 15 parts of simpleleaf shrub chastetree fruit, 12 to 15 parts of tall gastrodia tuber, 12 to 15 parts of grassleaf sweelflag rhizome, 10 to 12 parts of spina gleditsiae, 12 to 15 parts of ramulus et uncus uncariae, 8 to 10 parts of clematis root, 12 to 15 parts of pericarpium trichosanthis, 10 to 12 parts of szechuan lovage rhizome, 12 to 15 parts of Chinese angelica, 8 to 10 parts of divaricate saposhnikovia root, 12 to 15 parts of angelica dahurica, 20 to 30 parts of astragalus, 10 to 12 parts of green tangerine peel, 5 to 6 parts of liquoric root and 12 to 15 parts of root of red-rooted salvia. The preparation is prepared by the following steps of: mixing and grinding the raw materials into powder; decocting the powder; concentrating the decoction product into paste; drying the paste by the conventional method to obtain a powder mixture, namely, a finished product; and packaging the powder mixture into tablets or capsules. The preparation has the effects of radically curing intractable angioneurotic headache and qi stagnation headache caused by the cerebrovascular neuropathic pain and by taking the preparation, a patient can be cured rapidly without taking medicaments for a long time in the conventional way.

The invention discloses an oral compound traditional Chinese medicine preparation for preventing poultry chill cold and flu. The traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight through even mixing: 120-200 parts of schizonepeta, 50-80 parts of ox horn wire, 15-35 parts of taurine, 20-60 parts of shikimic acid, 80-150 parts of gypsum, 1-3 parts of borneol, 80-150 parts of mint, 80-150 parts of herba violae, 30-80 parts of rhizoma phragmitis, and 10-50 parts of isatis root. The compound preparation is compounded by adopting traditional Chinese medicine extracts and traditional Chinese medicine powder with unique effects, has the effects of diminishing inflammation, killing bacteria, resisting virus, strengthening heart, relieving cough, resisting allergic reaction, improving poultry disease resisting immunity, repairing damaged mucous membranes and effectively controlling secondary infection, and has efficient treating effect on the poultry influenza and flu. The oral compound traditional Chinese medicine preparation has the advantages of reasonable and scientific formula, simple preparation, prominent effect and wide application, and can be used as the priority drug for preventing and treating the poultry influenza and flu.

The invention provides application of resveratrol in medical titanium alloy implants under the condition of diabetes. The application has the advantages that by establishing a medical titanium alloy surface osteogenesis cell culture system, the following key treatment functions of the resveratrol are demonstrated, namely that the cell activity of titanium-bone interface osteogenesis cell in diabetes is improved; the osteogenic differentiation efficiency of the osteogenesis cell is improved; the adhesion state of the osteogenesis cell on the material surface is improved; the capacity of the osteogenesis cell resisting oxidizing stress injury caused by diabetes environment is improved; the pathological apoptosis of the osteogenesis cell is reduced; in addition, the osseointegration effect of the medical titanium alloy implant in a diabetes animal is improved by the resveratrol; the resveratrol can be used as a new drug or titanium alloy implant functional improving composite material ingredient to improve the osseointegration effect of the titanium alloy implant of a diabetes patient.

The present invention relates to a solid preparation of clopidogrel hydrochloride and its preparation method. It is characterized by that in said sold preparation the palmitoleostearin and micropowder silica gel are added, and its preparation method adopts a grinding equivalent progressively-increasing method so as to raise the stability and safety of said solid preparation.

The present invention relates to an immunoliposome preparation or a hydrophobic molecule-modified antibody having a therapeutic effect on cancer, autoimmune disease, or inflammatory disease. Specifically, the present invention relates to an immunoliposome or a hydrophobic molecule-modified antibody comprising, as a constituent, an antibody capable of inducing the apoptosis of cells expressing a death domain-containing receptor.

The invention discloses a huperzine-A solid dispersion and a method for preparing a tablet thereof. The huperzine-A solid dispersion comprises huperzine-A and a carrier used as a dispersant; the weight ratio range of the carrier to the huperzine-A is 1-25:1; the carrier material may be one or more of polyvinylpyrrolidone, polyethylene glycol 4000, polyethylene glycol 6000, Poloxamer 188, mannitol, lactose or microcrystalline cellulose; and the huperzine-A solid dispersion is prepared by adopting a grinding method, and the obtained solid dispersion can be prepared into huperzine-A tablets by adopting a wet granulating and tabletting method. The huperzine-A solid dispersion can remarkably increase the solubility of a medicament and promote the absorption so as to greatly improve the dissolution and bioavailability of the medicament.

The invention belongs to the field of medicinal preparations and in particular relates to a Dasatinib dispersoid, a preparation method thereof and an application thereof in preparation of Dasatinib dispersible tablets. Dasatinib solid dispersoid is prepared by using Dasatinib as an active ingredient and is prepared into tablets of different specifications. The Dasatinib solid dispersible tablets overcome the defects of incomplete release of the medicine and low bioavailability caused by that the dispersible common oral tablets are easy to adhere in the medicine releasing process, so that the bioavailability of the Dasatinib medicine can be further improved and the therapeutic effect of the medicine can be effectively exerted. The preparation process is simple, convenient and practical.

The invention discloses skin physiology repair liquid and a preparation method thereof. The skin physiology repair liquid is prepared by confecting and concentrating composite chitosan solution, gelatin, glycerin and Chinese herb extraction liquid; wherein, the composite chitosan solution is prepared by concentrating chitosan, water soluble low-molecular weight chitosan, chitosan hydrochloride and carboxymethyl chitosan, which are dissolved in diluted citric acid; the Chinese herb extraction liquid is extracted from coptis chinensis, fructus cnidii, radix scutellariae, rosemary, lightyellow sophora root, sophora alopecuroides, mulberry leaf, snow lotus and propolis. The invention achieves the effective rate of 89% in the first course of treatment of blain spots, cutaneous pruritus, contact dermatitis, allergic prurigo and spots and the effective rate of 95% in the second course of treatment. Antibacterial effects on gonococcus, staphylococcus aureus, colon bacillus and white cocci in laboratories excel the antibacterial effects of the commonly-used product Jieeryin lotion. The skin physiology repair liquid achieves the cure rate of 95% in the first course of treatment of gynecological leucorrhoea peculiar smell, vagina pruritus, congestion of vagina mucosa and vulva peculiar smell and the cure rate of 100% in the second course of treatment.

The invention discloses a pyrimidine-2, 4-diamine compound and a preparation method and application thereof, and relates to the technical field of medicinal chemistry, the pyrimidine-2, 4-diamine compound can be used for biological or pharmacological phenomena, cathepsin C participated signal channel conduction research, and evaluation of a novel cathepsin C inhibitor; in addition, through in-vitro and in-vivo anti-cathepsin C activity screening, the results show that the compound has relatively strong inhibitory activity on cathepsin C; through in-vivo anti-neutrophil serine protease activity screening, the result shows that the compound has relatively strong inhibitory activity on neutrophil serine protease; in-vivo anti-inflammatory activity screening results show that the compound has an effective treatment effect on an inflammatory disease model; meanwhile, the toxicity is low, and the application prospect is good.