Snuff

A technology for powders and medicines, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, digestive systems, etc., and can solve the problems of economic burden, inconvenient use, slow onset of oral tablets, and low bioavailability.

Inactive Publication Date: 2003-11-05
INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Intravenous injection of injections requires a specific environment and is limited to use in hospitals, and patients have to bear certain pains and high economic burdens and are inconvenient to use; oral tablets need to be taken a certain time in advance before treatment due to their slow onset of action, and low bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Weigh 11.2 g of granisetron hydrochloride fine powder (calculated as granisetron 10.0 g) that has been pulverized through a 120 mesh sieve, and set aside. In addition, 388.8 g of lactose, which was accurately weighed and crushed through a 100-mesh sieve, was set aside. The above-mentioned granisetron hydrochloride and lactose were uniformly mixed in an equal-volume ascending method, and sieved again for 3 times to obtain a nasal powder containing granisetron hydrochloride. Embodiment 2. After nasal powder of the present invention and tablet are administered, in blood drug concentration peak concentration time (T max ) and peak concentration (C max )Comparison

Embodiment 2

[0015] The nasal powder containing 2mg granisetron (hereinafter referred to as preparation A) was prepared according to the method of Example 1; in addition, a tablet containing 2mg granisetron was used. Divide 8 Beagles into two groups, with 4 Beagles in each group. The above-mentioned granisetron nasal powder and granisetron tablet were given to the above-mentioned two groups of animals respectively, and the time (T max ) and the corresponding maximum blood concentration C max , and the results are shown in Table 1 below.

[0016] Table 1

[0017] parameters

[0018] As can be seen from the data in Table 1, the granisetron nasal powder of the present invention is obviously better than the granisetron tablet in the absorption and onset of the drug.

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PUM

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Abstract

The present invention is snuff of setron medicine includes the medicine component selected from Ondansetron, tropisetron and granisetron; and medicine carrier selected from glucose, mannitol, lactose, sorbitol, microcrystalline cellulose and beta-cyclodextrin.

Description

field of invention [0001] The invention relates to a nasal powder for administering setron antiemetic drugs through nasal cavity. Setron drugs include Ondansetron (also known as Shufuning, Odanxiron, Iofran), Tropisetron (Topiseron, Vomiting, Navoban) and Granisetron (Gracey). Long, Kangquan, Kytril). Further, the nasal powder of the setron-like medicine includes a medicine selected from ondansetron, tropisetron and granisetron and a pharmaceutical carrier. Background technique [0002] Setron antiemetic drugs are potent and highly selective peripheral and central nervous system 5-HT 3 Receptor antagonist, through 5-HT on abdominal centripetal nerve fibers and solitary tract or emetic chemoreceptor zone of upper small intestine 3 The blocking effect of receptors can prevent or treat nausea and vomiting caused by chemotherapy and radiotherapy in cancer patients. Compared with other traditional drugs, it has the characteristics of high efficiency, low toxicity, safety and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/72A61K31/4178A61K31/439A61P1/08
Inventor 高永良王东兴张振清袁本利袁淑兰乔建忠孙建绪余寿忠
Owner INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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