Traditional Chinese medicine combination for preventing and treating delayed nausea and vomiting caused by chemotherapy and application thereof

A technology of nausea and vomiting and composition, which is applied in the field of traditional Chinese medicine composition, can solve the problems of increasing the control rate of delayed nausea and vomiting, reducing the incidence of delayed nausea and vomiting, and patients' difficulty in insisting on continuous medication, etc., achieving broad clinical application prospects, high Social benefit and economic benefit, the effect of good control effect

Active Publication Date: 2015-09-16
山东省医学科学院附属医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is a lack of effective anti-vomiting drugs clinically, and the control rate of delayed nausea and vomiting for the first-generation 5-HT3 receptor antagonist is about 28%; the second-generation 5-HT3 receptor antagonist palonosetron and The combined use of dexamethasone has been confirmed by a large number of studies to reduce the incidence of delayed nausea and vomiting. The control rate of delayed nausea and vomiting is 35%-41%, and the incidence of treatment-related adverse reactions is 44%.
The curative effect of continuous medication of 5-HT3 receptor antagonists is not ideal, and its adverse reactions such as constipation and abdominal distension make it difficult for patients to

Method used

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  • Traditional Chinese medicine combination for preventing and treating delayed nausea and vomiting caused by chemotherapy and application thereof
  • Traditional Chinese medicine combination for preventing and treating delayed nausea and vomiting caused by chemotherapy and application thereof
  • Traditional Chinese medicine combination for preventing and treating delayed nausea and vomiting caused by chemotherapy and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0045] The medicine formula of the present invention is as follows: 22 parts of ginger pinellia, 16 parts of cassia twig, 12 parts of Huoxiang, 12 parts of amomum, 10 parts of evodia, 8 parts of inula, 5 parts of tangerine peel, 5 parts of chuanxiong, 14 parts of ginger juice, menthol 1 serving.

[0046] The above-mentioned medicine is made into ointment, and the method is as follows:

[0047] (1) Take ginger Pinellia, Guizhi, Huoxiang, Amomum, Evodia, Inula, Tangerine Peel, Chuanxiong, and Menthol, and grind them into 300-320um (micron) micro-powders for later use;

[0048] (2) Soak the crushed amomum in water for 0.5h, then add water with 96 times the mass of amomum, and extract by steam distillation for 8-10h to obtain volatile oil of amomum, which is set aside;

[0049] (3) Wash the fresh ginger, squeeze the juice, filter to get the juice, and get the ginger juice for later use;

[0050] (4) Mix crushed ginger Pinellia, Guizhi, Huoxiang, Evodia, Inula, tangerine peel, Ch...

Embodiment 2

[0052] The pharmaceutical formula of the present invention is as follows: 20 parts of ginger pinellia, 20 parts of cassia twig, 10 parts of Huoxiang, 15 parts of amomum, 8 parts of evodia, 10 parts of inula inula, 4 parts of tangerine peel, 6 parts of chuanxiong, 10 parts of ginger juice, menthol 3 copies.

[0053] The preparation method is the same as in Example 1.

Embodiment 3

[0055] The medicinal formula of the present invention is as follows: 25 parts of ginger pinellia, 15 parts of cassia twig, 15 parts of Huoxiang, 10 parts of amomum, 12 parts of evodia, 4 parts of inula, 6 parts of tangerine peel, 4 parts of chuanxiong, 16 parts of ginger juice, menthol 1 serving.

[0056] The preparation method is the same as in Example 1.

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Abstract

The invention discloses a traditional Chinese medicine combination for preventing and treating delayed nausea and vomiting caused by chemotherapy. The traditional Chinese medicine combination comprises, by weight, 20-25 parts of pinellia rhizoma prepared by ginger, 15-20 parts of cassia twigs, 10-15 parts of agastache rugosus, 10-15 parts of fructus amomi, 8-12 parts of fructus evodiae, 4-10 parts of inula flower, 4-6 parts of pericarpium citri reticulatae, 10-16 parts of ginger juice and 1-3 parts of menthol. The traditional Chinese medicine combination has the advantages of being rigorous in composition, easy to prepare, free of stimulus, low in cost, easy to operate and capable of being accepted by patients easily. The traditional Chinese medicine combination is combined with granisetron and dexamethasone for use, can well treat delayed nausea and vomiting and loss of appetite caused by cis-platinum, also can relieve the side effects, like constipation of patient, caused by the usage of the granisetron and dexamethasone, provides a novel way for delayed nausea and vomiting patients, fills the blank of treating the delayed nausea and vomiting through traditional Chinese medicine at home and abroad, and reaches the international leading level.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for preventing and treating delayed nausea and vomiting caused by chemotherapy. Background technique [0002] Delayed nausea and vomiting is vomiting that occurs 24 hours after chemotherapy. Usually occurs 48-72 hours, sometimes up to 120 hours later. Delayed nausea and vomiting occurred in 19%-33% and 49%-75% of patients receiving moderate- and high-emetic-risk chemotherapy, respectively. Cisplatin is a broad-spectrum antineoplastic drug widely used clinically at present, and has a high risk of causing emesis, and 70-80% of patients will experience delayed nausea and vomiting. At present, there is a lack of effective anti-vomiting drugs clinically, and the control rate of delayed nausea and vomiting for the first-generation 5-HT3 receptor antagonist is about 28%; the second-generation 5-HT3 receptor antagonist palonosetron...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P1/08A61K31/045A61K35/57
Inventor 盛立军张富平孙亚红张卫华何伟娜
Owner 山东省医学科学院附属医院
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