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Patch used for treating nausea and vomiting, and preparation method thereof

A patch and preparation technology, which is applied in the field of patch for the treatment of nausea and vomiting and its preparation, and can solve problems such as unfavorable use and difficulty in dissolution

Inactive Publication Date: 2013-07-24
HENAN LINGRUI PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Granisetron hydrochloride is water-soluble, and it is difficult to dissolve in the organic solvent solution of the adhesive. Even if it can be dissolved, granisetron hydrochloride will crystallize over time, which is very unfavorable for use

Method used

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  • Patch used for treating nausea and vomiting, and preparation method thereof
  • Patch used for treating nausea and vomiting, and preparation method thereof
  • Patch used for treating nausea and vomiting, and preparation method thereof

Examples

Experimental program
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Embodiment 1、2

[0029] Embodiment 1, 2, comparative example 1~7

[0030] According to the proportion shown in Table 1, the adhesive solution A, isopropyl myristate, diethanolamine laurate and rosin ester were uniformly mixed to prepare an adhesive composition solution. If the drug to be added is granisetron hydrochloride, after adding the water amount specified in Table 1 (pH=10) to ethanol, add granisetron hydrochloride to dissolve, and then mix the drug solution and the binder solution with acetone to obtain the drug - Binder solution. If the added drug is granisetron, the drug is directly dissolved in ethanol, then added to the adhesive composition solution and mixed uniformly to obtain a drug-adhesive solution. The prepared drug-adhesive solution was coated on a polyethylene terephthalate (PET) film with a thickness of 40 μm, and the thickness of the coating film was controlled so that the thickness of the film after drying was 100 μm. 0 C temperature is dried for 24 hours, and the perc...

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PUM

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Abstract

The invention relates to a transdermal patch used for treating nausea and vomiting, and a preparation method thereof. The invention provides a transdermic-absorption frame-work patch. A ransdermic-absorption preparation layer composed of an acrylic adhesive, isopropyl myristate, diethanolamine laurate, rosin ester, and granisetron with a weight ratio of 40-70:5-30:2-10:5-24:5-15 is laminated on one side of a backing layer which is non-permeable to medicine.

Description

technical field [0001] The invention relates to a granisetron (hydrochloride) skeleton drug percutaneous absorption patch and a preparation method thereof. Background technique [0002] (hydrochloride) granisetron [chemical name 1-methyl-N-(endo-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)-lH-indazole-3-methanol Amide (hydrochloride)] is a selective antagonist of 5-HT receptors. By blocking the 5-HT3 receptors of the afferent abdominal vagus nerve endings, it has a good effect on inhibiting nausea and vomiting caused by antineoplastic drugs. (Special Publication No. 5-502872) [0003] Granisetron (hydrochloride) is used to suppress nausea and vomiting caused by taking antineoplastic drugs, and it needs to be taken continuously for a long time. And generally the taking object of this medicine is the patient with handicap mostly, and patient self is more difficult to take orally. Although it can also be administered by injection, it will bring pain to the patient and affect the...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/439A61K47/32A61P1/08
Inventor 熊维政武惠斌张军兵聂红梅汪平卢玉斌
Owner HENAN LINGRUI PHARMA
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