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Nasal spray agent

A technology for nasal sprays and sprays, applied in the field of sprays, which can solve the problems of economic burden and inconvenient use, slow onset of oral tablets, and low bioavailability

Inactive Publication Date: 2003-11-05
INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Intravenous injection of injections requires a specific environment and is limited to use in hospitals, and patients have to bear certain pains and high economic burdens and are inconvenient to use; oral tablets need to be taken a certain time in advance before treatment due to their slow onset of action, and low bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Weigh 1.12 g of granisetron hydrochloride fine powder (calculated as granisetron 1.0 g) that has been pulverized through an 80-mesh sieve, and set aside. Dissolve 0.06g of ethyl p-hydroxybenzoate and 1.8g of sodium chloride in 200ml of distilled water and set aside. Put the above-mentioned granisetron hydrochloride in a 100ml volumetric flask, add 90ml of the above-mentioned mixed solution, shake to dissolve, add the solution to the full amount of 100ml, and filter under reduced pressure with a G3 or G4 vertical fusing glass funnel to obtain granisetron hydrochloride Liquid medicine for nasal spray. Embodiment 2. After the spray of the present invention and tablet are administered, in blood drug concentration peak concentration time (T max ) and peak concentration (C max )Comparison

Embodiment 2

[0014] The nasal spray containing 2mg granisetron (hereinafter referred to as preparation A) was prepared according to the method of Example 1; in addition, a tablet containing 2mg granisetron was used. Divide 8 Beagles into two groups, with 4 Beagles in each group. The above-mentioned granisetron nasal spray and granisetron tablet were given to the above-mentioned two groups of animals respectively, and the time (T max ) and the corresponding maximum blood concentration C max , and the results are shown in Table 1 below.

[0015] Table 1

[0016] parameters

[0017] As can be seen from the data in Table 1, the granisetron nasal spray of the present invention is significantly better than the granisetron tablet in the absorption and onset of the drug.

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PUM

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Abstract

The present invention is nasal spray of setron medicine includes the medicine component selected from Ondansetron, tropisetron and granisetron, osmotic pressure regulator and water.

Description

field of invention [0001] The invention relates to a spray for administering setron type antiemetic medicine through nasal cavity. Setron drugs include Ondansetron (also known as Shufuning, Odanxiron, Iofran), Tropisetron (Topiseron, Vomiting, Navoban) and Granisetron (Gracey). Long, Kangquan, Kytril). Further, the nasal spray of a setron-like drug includes a drug selected from ondansetron, tropisetron and granisetron, an osmotic pressure regulator and water. Background technique [0002] Setron antiemetic drugs are potent and highly selective peripheral and central nervous system 5-HT 3 Receptor antagonist, through 5-HT on abdominal centripetal nerve fibers and solitary tract or emetic chemoreceptor zone of upper small intestine 3 The blocking effect of receptors can prevent or treat nausea and vomiting caused by chemotherapy and radiotherapy in cancer patients. Compared with other traditional drugs, it has the characteristics of high efficiency, low toxicity, safety an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K31/439A61P1/08
Inventor 高永良王东兴乔建忠袁本利袁淑兰张振清孙建绪余寿忠
Owner INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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