Granisetron and dexamethasone compound percutaneous controlled release patch and preparation method thereof

A technology of dexamethasone and compound recipe, applied in the field of pharmaceutical preparations, can solve the problems of unstable penetration, large difference in oil-water partition coefficient, etc.
CN103222977AInactive Publication Date: 2013-07-31NANJING UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANJING UNIV OF TECH
Publication Date
2013-07-31
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the field of pharmaceutic preparations and in particular relates to a granisetron and dexamethasone compound percutaneous controlled release patch and a preparation method thereof. The granisetron and dexamethasone compound percutaneous controlled release patch is characterized by being composed of a lining layer, a pressure-sensitive adhesive skeleton pattern medicine-containing storage layer and a protective film, wherein the pressure-sensitive adhesive skeleton pattern medicine-containing storage layer contains granisetron, dexamethasone, a transdermal penetration enhancer, a cross-linking agent, a plasticizer and pressure-sensitive adhesive, the transdermal penetration enhancer is azone preferably, and the content of azone is 2-5wt% based on the total weight of the pressure-sensitive adhesive skeleton pattern medicine-containing storage layer. The granisetron and dexamethasone compound percutaneous controlled release patch overcomes the defect that osmolality is unstable as difference between oil-water partition coefficients of granisetron and dexamethasone is large, and two medicines, namely granisetron and dexamethasone with different physical and chemical properties, have high osmolality and also maintain high blood concentration in a long time.
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Description

technical field

[0001] The invention relates to the field of pharmaceutical preparations, in particular to a compound transdermal controlled-release patch for treating nausea and vomiting caused by chemotherapy, radiotherapy or postoperative treatment and a preparation method thereof. Background technique

[0002] The chemical name of granisetron is 1-methyl-N-(9-methyl-9-azabicyclo[3,3,1]nonan-3-yl)-1H-indole-3- Formamide, the molecular formula is C 18 h 24 N 4 O, white crystalline powder, granisetron is a potent and highly selective 5-HT 3 Receptor antagonist, its anti-emetic mechanism is highly selective blocking of abdominal vagus nerve terminal neurons, as well as 5-HT on the chemoemetic receptor area of ​​the fourth ventricle and intestinal mucosal enterochromaffin cells 3 receptor. Granisetron and Modulation of 5-HT on Vomiting Tissue 3 Receptor binding sites have high affinity and high selectivity.

[0003] The chemical name of Dexamethasone is 16α-methyl-11β,...

Claims

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