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Permeation accelerator and application thereof to permeation acceleration

A technology of transdermal enhancer and natural extract, which is applied in the field of traditional Chinese medicine preparations, can solve the problems of chemical PE not strong specificity, human mucous membrane stimulation, etc., and achieve good penetration promoting effect, low toxic and side effects, and good market prospects Effect

Inactive Publication Date: 2015-07-08
GANSU UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

The specificity of these synthetic chemical PEs is not strong, and they have a greater stimulating effect on human mucous membranes.

Method used

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  • Permeation accelerator and application thereof to permeation acceleration
  • Permeation accelerator and application thereof to permeation acceleration
  • Permeation accelerator and application thereof to permeation acceleration

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] One, the preparation of natural transdermal accelerator:

[0023] 1. Extraction and purification of evodia alkaloids:

[0024] Weigh three parts of Evodia rutaecarpa, each 500g, add 6 times the amount of 70% ethanol to each part, heat and reflux for extraction twice, each time for 3 hours, filter, combine the filtrates, recover ethanol, concentrate, and dry to obtain 452g of dry cream. Or first extract the volatile oil from the medicinal materials, dry the residue, continue to extract with 70% ethanol, concentrate and dry the extract to obtain a dry cream. Take 40g of the dry cream, grind it finely, put it in a 1000mL round bottom flask, add 250mL of acetone, put it in a water bath, heat and reflux at 60°C for 1h, filter, recover the acetone from the filtrate, concentrate it to nearly dry, and get about 5.0g of thick cream, add an appropriate amount of neutral Alumina is stirred, ground into fine powder, and put on a neutral alumina (100-200 mesh) column. Column 1...

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Abstract

The invention discloses a permeation accelerator. An effective component of the permeation accelerator is a natural extractive. The invention further provides the application of the permeation accelerator to permeation acceleration. The permeation accelerator disclosed by the invention has the beneficial effects that the permeation accelerator and the application of the permeation accelerator disclosed by the invention have good permeation acceleration effect; and the natural extractive is used so that the toxic side effect is low, the irritation is low and the market prospect is good.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a transdermal accelerator and its application. Background technique [0002] Transdermal drug delivery systems (TDDs for short) are currently the most popular new type of preparation, which can maintain a stable blood drug concentration, avoid enzymatic hydrolysis in the gastrointestinal tract and the "first-pass effect" of the liver , reduce the toxic and side effects of drugs, and convenient administration. However, due to the barrier function of the skin and the physical and chemical properties of the drug itself, the penetration rate of many drugs through the skin is very low, and it is difficult for the drug to reach the effective therapeutic concentration through the skin. Application of transdermal absorption enhancers (penetration enhancers, PE) is the preferred method to increase drug transdermal absorption. Currently commonly used transdermal a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/46A61K47/44A61K47/20A61K47/22A61K31/192A61K36/232A61K36/237A61P7/00A61P9/00A61P29/00
Inventor 刘永琦李芸魏舒畅
Owner GANSU UNIV OF CHINESE MEDICINE
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