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Penetration enhancer and application of penetration enhancer in permeation enhancement

A transdermal enhancer and application technology, applied in the field of traditional Chinese medicine preparations, can solve the problems of poor chemical PE specificity and large stimulation effect on human mucous membranes, and achieve the effects of good penetration promotion effect, low toxic and side effects, and good market prospects.

Inactive Publication Date: 2014-11-26
GANSU UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The specificity of these synthetic chemical PEs is not strong, and they have a greater stimulating effect on human mucous membranes.

Method used

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  • Penetration enhancer and application of penetration enhancer in permeation enhancement
  • Penetration enhancer and application of penetration enhancer in permeation enhancement
  • Penetration enhancer and application of penetration enhancer in permeation enhancement

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] One, the preparation of natural transdermal accelerator:

[0021] 1. Extraction and purification of total alkaloids of Evodia rutaecarpa:

[0022] Weigh three parts of Evodia rutaecarpa, each 500g, add 6 times the amount of 70% ethanol to each part, heat and reflux for extraction twice, each time for 3 hours, filter, combine the filtrates, recover ethanol, concentrate, and dry to obtain 452g of dry cream. Take 40g of the dry cream, grind it finely, put it in a 1000mL round bottom flask, add 250mL of acetone, put it in a water bath, heat and reflux at 60°C for 1h, filter, recover the acetone from the filtrate, concentrate it to nearly dry, and get about 5.0g of thick cream, add an appropriate amount of neutral Alumina is stirred, ground into fine powder, and put on a neutral alumina (100-200 mesh) column. Column 1: elute with 5BV ethyl acetate-dichloromethane (70:30); the flow rate is 1.0ml??min -1 , collect the filtrate by pointing samples, and recover the solvent...

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Abstract

The invention discloses a penetration enhancer, the effective components of the penetration enhancer are natural extract, and the invention also provides an application of the penetration enhancer. The penetration enhancer and the application have the beneficial effects that the permeation enhancing effect is good, due to the employed natural extract, the toxic and side effects are low, the stimulation is small, and the market prospect is good.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a transdermal accelerator and its application. Background technique [0002] Transdermal drug delivery systems (TDDs for short) are currently the most popular new type of preparation, which can maintain a stable blood drug concentration, avoid enzymatic hydrolysis in the gastrointestinal tract and the "first-pass effect" of the liver , reduce the toxic and side effects of drugs, and convenient administration. However, due to the barrier function of the skin and the physical and chemical properties of the drug itself, the penetration rate of many drugs through the skin is very low, and it is difficult for the drug to reach the effective therapeutic concentration through the skin. Application of transdermal absorption enhancers (penetration enhancers, PE) is the preferred method to increase drug transdermal absorption. Currently commonly used transdermal a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/71A61K31/7048A61K47/20A61K47/22A61K47/44A61K47/46
Inventor 刘永琦李芸魏舒畅
Owner GANSU UNIV OF CHINESE MEDICINE
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