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Percutaneous absorption patch and its production method

A technology for patches and preparations, which can be used in pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., and can solve problems such as insufficient research.

Active Publication Date: 2009-06-17
COSMED PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] However, in the percutaneous absorption matrix type preparation, it is necessary to have a binder capable of dissolving granisetron
However, due to insufficient research on adhesives, the adhesives with less skin irritation, suitable adhesion properties, not only dissolving granisetron, but also allowing granisetron to be released in the skin for a long time and quantitatively as the matrix Matrix type percutaneous absorption preparations have not yet

Method used

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  • Percutaneous absorption patch and its production method
  • Percutaneous absorption patch and its production method

Examples

Experimental program
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Effect test

Embodiment 1

[0041] Embodiment 1, Comparative Examples 1-6

[0042] According to the proportion shown in Table 1, binder solution A or binder solution B, isopropyl myristate and diethanolamine laurate were uniformly mixed to prepare binder solvent solution. Weigh sodium hydroxide according to the amount shown in Table 1, dissolve it in water, disperse it in methanol, add granisetron hydrochloride, and add acetone after the drug dissolves to prepare a drug solution. The drug solution is uniformly mixed with the binder vehicle solution to prepare a transdermal absorption preparation solution. This formulation solution is coated on a polyethylene terephthalate (PET) film with a thickness of 40 μm by a knife coater, and the thickness of the coating film is controlled so that the thickness of the film after drying is 100 μm. After drying for 24 hours, the percutaneous absorption matrix patch was prepared after the solvent evaporated.

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Abstract

The invention provides a granisetron transdermic absorption plaster with small skin irritation, proper adhesion performance, no crystallization due to granisetron at dissolved state, suitable for long-time proper-amount transdermic administration and preparation method thereof. The the copolyers of 60-70weight% of acrylic acid 2-ethylhexyl ester and 40-30weight% of vinyl-pyrrolidone, a transdermic absorption preparation layer composed of isopropyl myristate, lauric acid diethanolamine and granisetron according the weight ratio of 100:5 - 20:1 - 10:5 - 10 are laminated on one side of a backing layer without permeability to the medicine.

Description

technical field [0001] The invention relates to a skeleton type percutaneous absorption patch containing granisetron and a preparation method thereof. Background technique [0002] Granisetron is a selective antagonist of the 5-HT receptor. It has a good effect on suppressing nausea and vomiting caused by antineoplastic drugs. (for example, Patent Document 1) [0003] Patent Document 1: Special Publication No. 5-502872 [0004] Granisetron is used to suppress nausea and vomiting caused by taking antineoplastic drugs, and it needs to be taken continuously for a long time. And generally the taking object of this medicine is the patient with handicap mostly, and patient self is more difficult to take orally. Although it can also be administered by injection, it will bring pain to the patient and affect the quality of life. Therefore, a transdermal preparation of granisetron has been proposed. [0005] For example, with granisetron or granisetron salt as the active ingredi...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/32A61K47/18A61K31/439A61P1/08
Inventor 神山文男权英淑
Owner COSMED PHARMA
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