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Granisetron membrane preparation and preparation method

A technology of granisetron and film preparation, applied in the field of film preparation and preparation technology thereof, can solve the problems of insignificant effect, failure to absorb granisetron tablets or capsules, failure to reach therapeutic dose and the like

Inactive Publication Date: 2011-05-11
HEBEI AOXING GROUP PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Under this kind of psychological suggestion, the patient will have the feeling of vomiting as soon as he sees the conventional tablets and capsules, so even if he takes the granisetron tablets or capsules, due to the strong vomiting of the patient, the granisetron tablets or capsules will get sick. Less effective absorption, thus less than effective therapeutic dose, so the effect of treating vomiting is not significant

Method used

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  • Granisetron membrane preparation and preparation method
  • Granisetron membrane preparation and preparation method
  • Granisetron membrane preparation and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1 (prescription quantity 1000)

[0024]

[0025]

[0026] Accurately weigh 1 g of granisetron hydrochloride, add it to 100 ml of purified water, stir to dissolve, add hypromellose to swell, and after the swelling is uniform, add glycerin, sunset yellow, sodium benzoate, and stevia, and stir evenly. Vacuumize or sonicate the prepared solution to remove air bubbles. Adjust the position of the film applicator and the steel plate or glass plate to make it horizontal, then place the film solution on the steel plate or glass plate, apply the film slowly and evenly, and then place it in a horizontal position to dry in the shade. Semi-finished products are tested, assayed, film cut, packaged, and set aside.

Embodiment 2

[0027] Embodiment 2 (prescription quantity 1000)

[0028]

[0029] Accurately weigh 1g of granisetron hydrochloride, add it to 100ml of purified water, stir to dissolve, add hypromellose to swell, after the swelling is even, add glycerin, polyoxyethylene hydrogenated castor oil, brilliant blue, sodium benzoate, stevia, and stir well . Vacuumize or sonicate the prepared solution to remove air bubbles. Adjust the position of the film applicator and the steel plate or glass plate to make it horizontal, then place the film solution on the steel plate or glass plate, apply the film slowly and evenly, and then place it in a horizontal position to dry in the shade. Semi-finished products are tested, assayed, film cut, packaged, and set aside.

Embodiment 3

[0030] Embodiment 3 (prescription quantity 1000)

[0031]

[0032] Accurately weigh 1 g of granisetron hydrochloride, add it to 100 ml of purified water, stir to dissolve, add Kollicoat IR to dissolve, then add glycerin, sunset yellow, sodium benzoate, and stevia, and stir evenly. Vacuumize or sonicate the prepared solution to remove air bubbles. Adjust the position of the film applicator and the steel plate or glass plate to make it horizontal, then place the film solution on the steel plate or glass plate, apply the film slowly and evenly, and then place it in a horizontal position to dry in the shade. Semi-finished products are tested, assayed, film cut, packaged, and set aside.

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PUM

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Abstract

The invention discloses a granisetron membrane preparation and a preparation method of the granisetron membrane preparation. Granisetron, membrane-forming material, water, plasticizers, surface active agents, preservatives, coloring agents and flavoring agents are used for preparing membrane agents. The granisetron can be uniformly dispersed in the membrane material in a molecule state, in an amorphous or micelle mode, the membrane agents can be rapidly melted when contacting with water. The granisetron membrane preparation has the advantages that the dissolving is quick and the action is rapid.

Description

technical field [0001] The invention relates to a film preparation and a preparation process thereof, in particular to a granisetron instant film preparation and a preparation process thereof. Background technique [0002] Granisetron hydrochloride is a highly selective 5-HT 3 Receptor antagonist, has good preventive and therapeutic effects on nausea and vomiting caused by radiotherapy, chemotherapy and surgery. Factors such as radiotherapy, chemotherapy, and surgery can cause enterochromaffin cells to release 5-HT, and 5-HT can activate 5-HT in the central or vagal nerve endings 3 receptors that induce the gag reflex. The mechanism of this product to control nausea and vomiting is through the antagonism of 5-HT in the central chemoreceptor area and peripheral vagus nerve endings 3 receptors, inhibit the occurrence of nausea and vomiting. [0003] As the technology related to granisetron film preparation, known patent 200310109674.7 (antiemetic granisetron hydrochloride ...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/439A61P1/08
Inventor 刘福利滑千里杨丽英赵学刚赵晓雷王乃浩张雪雷陈永帅张丽霞
Owner HEBEI AOXING GROUP PHARMA
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