Desonide cyclodextrin clathrate compound and method for preparing the same

A technology of cyclodextrin inclusion compound and cyclodextrin, which is applied in the field of cyclodextrin inclusion compound of desonide, can solve the problems of main drug content decrease, affect product stability, easy decomposition, etc., and achieve formulation stability Improved effect

Active Publication Date: 2008-03-05
CHONGQING HUAPONT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, desonide is easy to decompose, especially under the condition of aqueous solution and light
The main drug content

Method used

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  • Desonide cyclodextrin clathrate compound and method for preparing the same
  • Desonide cyclodextrin clathrate compound and method for preparing the same
  • Desonide cyclodextrin clathrate compound and method for preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1 Preparation of desonide / β-cyclodextrin (molecular ratio: 2: 1) inclusion compound

[0027] Add 1.36g of β-cyclodextrin (β-CD) into 73.5ml of water to make a saturated solution, dissolve and clarify under stirring; take another 1g of desonide raw material, dissolve it with 5ml of ethanol, slowly add β-CD under stirring to saturate In the solution, add ultrasonication for 60 minutes; stand still, filter the obtained precipitate, and wash with ethanol, and dry the obtained precipitate in an oven at 70°C for 6 hours to obtain cyclodextrin inclusion complex, which is a white solid in appearance. The content and encapsulation efficiency of the main drug in the inclusion compound are shown in Table 2.

[0028] Cyclodextrin inclusion complex detection

[0029] 1) UV absorption experiment

[0030] Scan the desonide solution with ultraviolet light to obtain the ultraviolet spectrum; calculate the content of desonide in the inclusion compound according to the conten...

Embodiment 2

[0036] Embodiment 2 Preparation of desonide / β-cyclodextrin (molecular ratio: 1: 1) inclusion compound

[0037] Add 2.72 g of D-cyclodextrin to 147 ml of water to form a saturated solution, and the rest are the same as in Example 1.

Embodiment 3

[0038] Example 3 Preparation of desonide / β-cyclodextrin inclusion compound (molecular ratio: 1:2)

[0039] Add 5.45 g of β-cyclodextrin and 295 ml of water to form a saturated solution, and the rest are the same as in Example 1.

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PUM

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Abstract

The present invention relates to cyclodextrin inclusion compound of desonide and its preparation process. The cyclodextrin inclusion compound of desonide has molecule ratio between desonide and cyclodextrin of 0.1-2. It is prepared through adding the alcohol solution of desonide into the water solution of cyclodextrin to include. Compared with common desonide preparation, the cyclodextrin included desonide preparation has obviously raised stability.

Description

Technical field: [0001] The invention relates to a cyclodextrin inclusion compound of desonide. The invention also relates to the preparation method of the desonide inclusion compound and its preparation. Background technique: [0002] Desonide is a glucocorticoid drug whose chemical name is 11β, 21-dihydroxy-16α, 17-[(1-methylethylene)-dioxo]pregna-1,4-di ene-3,20-dione. [0003] Desonide topical can treat a variety of skin diseases. Such as contact dermatitis, eczema and other allergic skin diseases; psoriasis, pityriasis rosea, lichen planus and other erythematous and scaly skin diseases; skin diseases caused by physical factors; pruritic skin diseases; skin vasculitis, etc. [0004] However, desonide is easy to decompose, especially under the conditions of aqueous solution and light. The main drug content of external preparations containing desonide decreases rapidly during the shelf life, which affects the stability of the product. Therefore, changing the physical ...

Claims

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Application Information

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IPC IPC(8): A61K47/40A61K31/58A61P37/08A61P17/00
Inventor 吴应纯李永胜刘均胜
Owner CHONGQING HUAPONT PHARMA
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