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General flavanone capsule of desmodium styracifolium and preparation method and application thereof

A technology of Desmodium stylifolia and total flavonoids, which is applied to the preparation of the total flavonoids capsules of Desmodium stylifolia in the preparation of drugs for the treatment of urinary calculi, the field of total flavonoids of Desmodium stylifolia and its preparation

Inactive Publication Date: 2014-07-02
HUMANWELL HEALTHCARE GRP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on the related preparations of total flavonoids of Desmodium stylifolia still needs to be strengthened

Method used

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  • General flavanone capsule of desmodium styracifolium and preparation method and application thereof
  • General flavanone capsule of desmodium styracifolium and preparation method and application thereof
  • General flavanone capsule of desmodium styracifolium and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0120] Example 1. Preparation of total flavonoid extract of Desmodium serrata

[0121] Take 200 g of the herbal medicine of Guangqiang, add 14 times the amount of 95% ethanol for the first time, heat reflux for 3 hours at 60°C, add 12 times the amount of 95% ethanol for the second time, heat reflux for 2 hours at 50°C. Add 80% ethanol of 8 times the amount of medicinal materials for the third time, heat and reflux for 1 hour at 50°C, combine the alcohol extracts; concentrate the alcohol extracts to a certain volume, make the volume of the medicinal solution 8 times the amount of medicinal materials, and filter by standing to obtain The filtrate (for the sample liquid), set aside. Soak 400 grams of pharmaceutical grade AB-8 type macroporous resin with an appropriate amount of ethanol, wet-pack the column, and prepare for use after treatment.

[0122] Pass the above-mentioned filtrate (loading drug solution) through the AB-8 macroporous adsorption resin column at a flow rate of 3 ti...

Embodiment 2

[0123] Example 2. Preparation of total flavonoid extract of Desmodium serrata

[0124] Take 200 g of the herbal medicine from Guangxi, add 12 times the amount of 70% ethanol for the first time, heat reflux at 55°C for 2 hours, add 10 times the amount of 70% ethanol for the second time, heat reflux for 1.5 hours at 55°C. Combine the alcohol extracts; concentrate the alcohol extracts to a certain volume so that the volume of the medicinal solution is 5 times the amount of the medicinal material, and stand and filter to obtain the filtrate (the sampled medicinal solution) for use. Soak 400 grams of pharmaceutical grade AB-8 type macroporous resin with an appropriate amount of ethanol, wet-pack the column, and prepare for use after treatment.

[0125] Pass the above-mentioned filtrate (loading drug solution) through the AB-8 macroporous adsorption resin column at a flow rate of 1 column bed volume per hour. After the adsorption is completed, first wash with 10 times the amount of resin...

Embodiment 3

[0126] Example 3. Preparation of total flavonoids extract of Desmodium Styracifolium

[0127] Take 50 kilograms of Chinese herbal medicine, add 12 times the amount of 80% ethanol for the first time, heat reflux at 55°C for 2 hours, add 10 times the amount of 80% ethanol for the second time, heat reflux at 55°C for 1.5 hours, Combine the alcohol extracts; concentrate the alcohol extracts to a certain volume so that the volume of the medicinal solution is 5 times the amount of the medicinal material, and stand and filter to obtain the filtrate (the sampled medicinal solution) for use. Soak 100 kilograms of pharmaceutical grade AB-8 type macroporous resin with an appropriate amount of ethanol, wet-pack the column, and prepare for use after treatment.

[0128] Pass the above-mentioned filtrate (loading solution) through the AB-8 macroporous adsorption resin column at a flow rate of 2 times the bed volume per hour. After the adsorption is completed, first wash with 10 times the amount o...

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Abstract

The invention provides a general flavanone capsule of desmodium styracifolium and a preparation method and application thereof, wherein the general flavanone capsule of the desmodium styracifolium comprises total flavanone of the desmodium styracifolium, which is an alcohol extract of the desmodium styracifolium, and pharmaceutically acceptable medicinal excipients. The general flavanone capsule of the desmodium styracifolium disclosed by the invention has the characteristics of being explicit in effective material basis, controllable in quality standard, good in drug dissolution degree, good in quality stability, significant in pharmacology and drug efficacy, less in dosage, safe and convenient to take, and completely applicable to industrial massive production.

Description

Technical field [0001] The invention belongs to the field of traditional Chinese medicine, and specifically relates to Desmodium vulgare total flavonoid capsules and a preparation method and application thereof. More specifically, the present invention relates to Desmodium lavandrinus total flavonoids capsules and a preparation method thereof, and the application of Desmodium lavandulatum total flavonoids capsules in preparing medicines for treating urinary calculi. Background technique [0002] Desmodium styracifolium is a legume plant. Desmodium styracifolium (Osb.) Merr. The dry aerial part of Desmodium styracifolium (Osb.) Merr. is a traditional Chinese medicine included in the 2010 edition of the Chinese Pharmacopoeia. . At the same time, the prescription of Shilintong tablets, whose main ingredient is Desmodium vulgare, is used for bladder damp-heat, shilin astringent pain, urinary tract stones, urinary tract infections belonging to hepatobiliary bladder damp-heat. Howeve...

Claims

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Application Information

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IPC IPC(8): A61K36/48A61K9/48A61P13/04
CPCA61K9/4875A61K36/48A61P13/00A61P13/04A61K9/48A61K9/4833A61K9/4858A61K9/4866A61K9/1623A61K9/1635A61K9/1652A61K9/1682A61K2236/33A61K2236/53
Inventor 王学海许勇李莉娥李杰涂荣华陈刚曹儒宾冯芸杨仲文范昭泽余艳平肖强黄璐杨成兵黄天赐田华杨菁
Owner HUMANWELL HEALTHCARE GRP
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