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Method for preparing core-shell type polysaccharide gum location targeting carrier material

A technology of carrier material and polysaccharide gel, which is applied in the field of preparation of core-shell polysaccharide gel positioning and targeting carrier materials, can solve the problems of increased metabolic burden on the body, high cost of carrier synthesis, and wide clinical application, so as to improve the therapeutic index of drugs, Good biocompatibility and biodegradability, the effect of reducing drug toxicity

Inactive Publication Date: 2015-12-16
ZHONGBEI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Although the drug carrier has developed rapidly and has many advantages and characteristics, its clinical application is not as extensive as expected. The main reason is that the introduction of the carrier greatly reduces the drug loading, and the presence of the carrier adds additional metabolism Burden, the synthesis of the carrier is costly and time-consuming. More importantly, it is difficult for multi-component drugs with synergistic therapeutic effects to enter the same dosage form simultaneously and quantitatively. In addition, the distribution and stability of the carrier-based drug in the body fluid environment There are also great challenges

Method used

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  • Method for preparing core-shell type polysaccharide gum location targeting carrier material
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  • Method for preparing core-shell type polysaccharide gum location targeting carrier material

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preparation example Construction

[0039] A preparation method for a positioning and targeting polysaccharide gum carrier material, the preparation method is to coat water-based iron ferric oxide with calcium pectin, and use a low-ester pectin carrier as a skeleton material to prepare a drug carrier. Triiron is modified by a hydrophilic group, and the preparation method comprises the following three steps:

[0040] S1: preparing water-based ferroferric oxide magnetic nanoparticles;

[0041] (1) Sodium citrate was dissolved in deionized water to obtain the first sodium citrate solution of 0.05~0.2g / mL;

[0042] (2) FeCl 3 and FeSO 4 Dissolve in 50mL distilled water at a molar ratio (1:1~1.5:1) to form Fe 2+ and Fe 3+ Under the protection of nitrogen, heat the above mixed solution to 50~60°C, add 8%~12% ammonia water dropwise to the mixed solution while stirring, until the pH value reaches 8~10, after 10 minutes of reaction, Add 20mL of the prepared second sodium citrate solution, and continue the reaction a...

Embodiment 1

[0057] Embodiment 1: The polysaccharide gum used is a natural low-ester polysaccharide gum, and the drug is cyclophosphamide.

[0058] Weigh 1.1g FeCl3 6H2O and 0.9g FeSO4 7H2O, dissolve them in 50mL of distilled water, heat the iron salt mixed solution to 50°C under the protection of nitrogen, add 10% ammonia water dropwise to the mixed solution while stirring, until pH After the value reaches 9, react for 10 min, add 20 mL of 0.2 g / mL sodium citrate solution, and continue to react for 30 min at 50°C. The product was cooled, washed three times with water after static magnetic absorption, and distributed in 300mL distilled water.

[0059] Weigh 0.2mg of natural low-ester polysaccharide gum and dissolve it in 100mL of distilled water, adjust the pH to 2 with hydrochloric acid, add 2mL of water-based ferroferric oxide magnetic fluid, 10mg of cyclophosphamide, after ultrasonic mixing, add dropwise 10mL of 300mg / mL CaCl2 solution , After the dropwise addition was completed, the r...

Embodiment 2

[0061] Embodiment 2: The polysaccharide gum used is a natural low-ester polysaccharide gum, and the drug is 5-fluorouracil.

[0062] Weigh 1.1g FeCl3 6H2O, 0.9g FeSO4 7H2O, dissolve in 50mL of distilled water, under the protection of nitrogen, heat the iron salt mixed solution to 50°C, add 10% ammonia water dropwise to the mixed solution while stirring, until the pH value After reaching 9, react for 10 min, add 20 mL of 0.2 g / mL sodium citrate solution, and continue to react for 30 min at 50°C. The product was cooled, washed three times with water after static magnetic absorption, and distributed in 300mL distilled water.

[0063] Weigh 0.2mg of natural low-ester polysaccharide gum and dissolve it in 100mL of distilled water, adjust the pH to 2.3 with hydrochloric acid, add 2mL of water-based ferroferric oxide fluid, 10mg of 5-fluorouracil, and after ultrasonic mixing, add 10mL of 300mg / mL CaCl2 solution dropwise, After the dropwise addition, the reaction was continued for 30...

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Abstract

The invention discloses a method for preparing a location targeting polysaccharide gum carrier material. According to the method, water-based ferroferric oxide is coated with calcium pectinate, a drug carrier is made with a low-methoxyl pectin carrier as a framework material, the ferroferric oxide is modified by a hydrophile group, targeting is achieved through the magnetic ferroferric oxide, drugs are located in the diseased region by means of the external magnetic field and then released, and in this way, drug content in normal tissue is reduced, drug utilization rate is increased, and drug toxicity is reduced; by taking the low-methoxyl pectin carrier as the framework material, toxicity is avoided, safety is achieved, biocompatibility and biodegradability are high, the therapeutic index of drugs can be increased, drug toxicity can be reduced, and the side effects of drugs can be reduced.

Description

technical field [0001] The invention belongs to the field of carrier materials for sustained and controlled release preparations, and in particular relates to a preparation method for a core-shell polysaccharide gum positioning and targeting carrier material. Background technique [0002] Cancer is a disease caused by the mutation of normal cells in the human body under the induction of certain external adverse factors, and the abnormal mechanism of cell growth and proliferation. Because of its difficulty in curing, it has become a major disease that seriously threatens human health. Chemotherapy is currently one of the conventional methods for treating cancer. It uses chemical drugs to kill cancer cells and inhibit the growth and proliferation of cancer cells. It is a systemic treatment. Since the selectivity of the anticancer drug itself is not strong, and in the case of excessive drug concentration, it will also damage the normal cells while killing the cancer cells, and ...

Claims

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Application Information

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IPC IPC(8): A61K47/36A61K47/02A61K9/51A61K41/00A61K31/675A61K31/513A61K31/704A61K31/337A61P35/00
Inventor 马雪梅马忠平周娅静胡志勇郭建峰曹端林徐霞贺圣龙
Owner ZHONGBEI UNIV
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