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Package for patch and packaging method

A packaging body and patch technology, applied in transportation and packaging, packaging, packaging food, etc., can solve the problems of rivastigmine stability, and achieve the effect of inhibiting the decrease of drug content and inhibition of adsorption

Inactive Publication Date: 2017-08-01
NICHIBAN KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the above-mentioned documents, the stability of rivastigmine is not discussed

Method used

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  • Package for patch and packaging method
  • Package for patch and packaging method
  • Package for patch and packaging method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0268] Lidocaine 3.0% by mass, SIS SIS5002 (styrene content 22% by mass, diblock ratio: 15% by mass, manufactured by JSR Co., Ltd.) 32.0% by mass, Pincrestal KE-311 (hydrogenated rosin glyceride, manufactured by Arakawa Chemical Co., Ltd.) as a high polar resin, 17.5% by mass, YS resin PX1150N (terpene resin, produced by Yasuhara Chemical Co., Ltd.) as a low polar resin 10.0% by mass, and 37.5% by mass of Hicol (registered trademark) M-352 (liquid paraffin, manufactured by Kaneda Co., Ltd.) as a softener (values ​​(mass%) are based on the total mass of the adhesive layer 100% by mass, the same applies hereinafter) and heated and stirred to prepare a uniform adhesive composition. In addition, the heating and stirring is the process of mixing the above-mentioned materials except drugs in a Henschel mixer under nitrogen protection at a temperature of 170°C and a rotation speed of 600rpm to a uniform state, and then setting the temperature at 140°C and a rotation speed of 200rpm. ...

Embodiment 2

[0306] As an acrylic adhesive, 40% by mass of DURO-TAK (registered trademark) 87-2516 (containing hydroxyl group, Henkel Co., Ltd.) and 60% by mass of ethyl acetate were mixed at room temperature to prepare an acrylic adhesive solution (value ( %) is based on the total mass of the binder solution). Then, this solution was placed on a PET film (Filmbina (registered trademark) 75E-0010 No. 23, manufactured by Fujimori Industries, Ltd.) with a thickness of 75 μm that was treated with silicone release as a release layer, and the thickness after drying was 80 μm. Apply and dry at 60-100°C to form an adhesive layer.

[0307] 90% by mass of rivastigmine and 10% by mass of Oidragit (registered trademark) EPO (Ebonick Degusa Corporation) were weighed respectively, placed in a glass bottle, and dissolved at room temperature to obtain a rivastigmine solution (value (%) is expressed as rivastigmine The total mass of Ting solution as a benchmark). The obtained rivastigmine solution was a...

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Abstract

To provide: a package for a patch, said package assuring a high temporal stability of a drug; a patch product comprising the patch and a packaging bag; and a method for manufacturing the patch product. A patch product comprising a packaging bag formed of a laminate consisting of three or more layers including a cyclic polyolefin film, and a patch enclosed within the packaging bag, said patch containing, in particular, lidocaine or rivastigmine; a method for manufacturing the patch product; and a package for a patch, said package being formed of a laminate including a cyclic polyolefin film.

Description

technical field [0001] The present invention relates to a packaging body of a patch and a packaging method for the patch, specifically, when packaging a patch containing a local anesthetic lidocaine or a patch containing an anti-dementia drug rivastigmine in a package, By providing a cyclic polyolefin (hereinafter also referred to as COC) film layer in the packaging material, it is possible to suppress the decrease in the drug content of the aforementioned patch over time and a method for producing the package of the patch. Background technique [0002] In order to suppress the decomposition of the drug contained in the patch and store the patch stably for a long period of time, some packaging materials have been reported. [0003] For example, in Patent Document 1, it is reported that while the influence of moisture on the drug in the patch can be sufficiently reduced, the patch can be stored stably for a long time, and at the same time, the moisture-absorbing Packing bag ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J1/00A61K9/70A61K31/167A61K31/27A61K45/00A61K47/06A61K47/14A61K47/32A61K47/34A61P23/02
CPCA61K45/00A61J1/00A61K31/167A61K31/27A61K9/7053A61K9/7061A61K9/7076A61P23/02A61P25/28A61K47/34A61K47/32A61K47/14A61K9/70
Inventor 户原侑希子松尾恭平大庭彩香成濑早矢加稻垣佳奈子
Owner NICHIBAN KK
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