29 results about "Butenedioic acid" patented technology

The invention discloses lighting resin as well as a preparation method and application thereof, and belongs to the technical field of lighting type unsaturated polyester resin. Comprising the following components: ethylene glycol, benzoic acid, phthalic anhydride, maleic anhydride, an antioxidant, a defoaming agent, a surfactant, a stabilizer, styrene, a solvent, a first polymerization inhibitor, a second polymerization inhibitor and a third polymerization inhibitor. The alcohol-acid ratio is (1.03-1.13): 1; the molar ratio of unsaturated acid to saturated acid is (2.5-3.5): 1; the mass ratio of benzoic acid to the surfactant is (26.8-44): 1; the preparation method comprises the following steps: 1) reacting ethylene glycol, maleic anhydride, phthalic anhydride, benzoic acid, an antioxidant and a first polymerization inhibitor; the preparation method comprises the following steps of (1) adding a first polymerization inhibitor, (2) heating and preserving heat after the reaction is completed, and (3) cooling, adding a second polymerization inhibitor, cooling, adding a third polymerization inhibitor, a cross-linking agent, a surfactant and a defoaming agent, and adding a solvent to obtain the daylighting resin.According to the preparation method, the surfactant and benzoic acid have a synergistic effect, so that the compatibility of polyester and the cross-linking agent is improved.

The invention relates to the field of pouring sealants, and discloses a modified epoxy resin pouring sealant and a preparation method thereof, the pouring sealant comprises epoxy resin, a modified inorganic filler, a modified additive and an auxiliary agent; the modified inorganic filler is prepared by grafting a quaternized s-triazine derivative and an inorganic filler; the quaternized s-triazine derivative is prepared through the steps that 3, 5-diaminophenylboronic acid, cyanuric chloride, 3-chloropropyltrimethoxysilane and 1, 4-butanediamine are sequentially subjected to substitution to prepare a s-triazine derivative, then the s-triazine derivative reacts with N, N-dimethyl-1, 3-diaminopropane, and bromoethane is used for quaternization treatment. The modified additive is prepared from a modified bismaleimide monomer prepared from maleic anhydride and 5 (6)-amino-1-(4-aminophenyl)-1, 3, 3-trimethylindane and 1-methyl-4-isopropyl cyclohexene through a self-stabilization precipitation polymerization method, the prepared pouring sealant is high in tensile strength, good in impact resistance and good in mechanical property, and the prepared pouring sealant has the advantages of being good in mechanical property, good in mechanical property and good in mechanical property. Meanwhile, good heat resistance, flame retardance, dielectricity and antibacterial activity are achieved.

This invention provides a breathable plaster matrix for application and its preparation method, belonging to the field of polymeric dressings and plasters. The plaster matrix raw materials include terpene-modified rosin beeswax, hydrogenated rosin glyceryl ester, camellia oil, castor oil, stearic acid hydrophobically modified microcrystalline cellulose, zinc oxide, glycerin, coated citric acid, sodium bicarbonate, polyethylene glycol, camphor, and menthol. The terpene-modified rosin beeswax is prepared by reacting rosin and α-pinene in the presence of di-tert-butylperoxyisopropylbenzene, followed by the addition of white beeswax and maleic anhydride, and then the addition of trimethylolpropane. The stearic acid hydrophobically modified microcrystalline cellulose is microcrystalline cellulose coated with stearic acid. The coated citric acid is citric acid coated with hydrogenated castor oil. This invention's plaster matrix significantly improves skin breathability, application comfort, and biocompatibility while ensuring sufficient adhesion, formability, and drug loading capacity.

The invention provides a temperature-resistant and salt-resistant polymer viscosity reducer for a drilling fluid and a preparation method of the temperature-resistant and salt-resistant polymer viscosity reducer. The phosphine-containing polymer viscosity reducer can be prepared from a carboxylic acid group-containing monomer, a sulfonic acid group-containing monomer, a phosphine-containing compound and phosphorous acid through a polymerization reaction; the carboxylic acid group-containing monomer is selected from one or more of acrylic acid, methacrylic acid and maleic acid, and the sulfonic acid group-containing monomer is selected from 2-acrylamido-2-methylpropanesulfonic acid or 2-acryloyloxy-2-methylpropanesulfonic acid; the phosphine-containing compound is selected from any one of ethylene diamine tetra (methylene phosphonic acid), 1-hydroxyethylidene-1, 1-diphosphonic acid and amino trimethylene phosphonic acid. The obtained phosphine-containing polymer viscosity reducer with the corresponding structure is good in temperature resistance and salt resistance, salt resistance reaches saturation, and under the conditions of high temperature and salt pollution, the viscosity reducer still has a good viscosity reduction effect and has good temperature resistance and salt resistance; and moreover, reaction raw materials in the preparation are few, the synthesis process is simple, the cost performance is relatively high, and application is facilitated.

The invention relates to an ultrahigh-temperature and high-salinity water shutoff system and a preparation method and application thereof, and belongs to the field of oilfield water shutoff systems, and the ultrahigh-temperature and high-salinity water shutoff system comprises the following substances in parts by weight: 8-10 parts of 2-acrylamido-2-methylpropanesulfonic acid, 6-10 parts of N-vinyl caprolactam, 6-8 parts of N-isopropylacrylamide and 4-6 parts of monostearyl maleate. The invention relates to a water-based adhesive which is prepared from the following components in parts by weight: 6 to 10 parts of 2-acrylamido-2-methylpropanesulfonic acid, 3 to 5 parts of dimethylaminoethyl methacrylate, 0.2 to 0.4 part of dimethyl 2-butenedioate trimethylolpropane triacrylate, 3 to 5 parts of modified nanoscale silicon dioxide, 2 to 4 parts of modified nanoscale calcium carbonate and 100 to 120 parts of deionized water. The plugging agent provided by the invention can still maintain good plugging performance in an oil reservoir environment in which the underground temperature of an oil field exceeds 120 DEG C and / or the degree of mineralization is higher than 100000mg / L, so that the plugging efficiency of a water seepage layer of an oil well in the oil field is ensured.

A process and apparatus for the production of maleic anhydride by reacting a mixed gas containing molecular oxygen and a hydrocarbon, usually n-butane, over a suitable catalyst, wherein the maleic anhydride is produced in a tubular catalytic reactor, wherein after recovery of the maleic anhydride product by absorption with an organic solvent and after appropriate treatment steps, the gaseous effluent from the reactor is recycled back to the inlet of the catalytic reactor by compression.

The present invention discloses a retarder for improving the setting time of magnesium phosphate cement, and its preparation method and application. The method comprises: (1) adding a reducing agent to a glucose solution in a protective atmosphere for hydroxylation treatment, and obtaining a hydroxylated glucose solution after the reaction is completed. (2) adjusting the pH of the hydroxylated glucose solution to alkaline, and then adding a mixed solution of NHS and EDC, and obtaining an activated glucose solution after the reaction is completed. (3) adding butenedioic acid and a catalyst to the activated glucose solution for esterification reaction, and then performing purification treatment after the reaction is completed to obtain a butenedioic acid esterified glucose derivative solution. (4) adjusting the pH of the butenedioic acid esterified glucose derivative solution to acidic, and then adding an acrylic acid monomer and an initiator, and performing a polymerization reaction under heating conditions, and then obtaining the retarder after the reaction is completed. The retarder of the present invention not only prolongs the setting time of magnesium phosphate cement, but also avoids the problem of strength loss.

The present application relates to the field of new material fine chemicals, and particularly relates to a low-cost preparation of a series of carbon four (C4) diacid (ester) by using coal chemical industry abundant oxalate and / or glycollic acid (ester) bulk raw materials, including butene diacid (ester), succinic acid (ester), tartaric acid (ester), and / or malic acid (ester) and the like, and the process features are that all of the coal chemical industry abundant carbon monoxide (synthesis gas), methanol, or formaldehyde and the like bulk C1 raw materials are used, and a series of C4 skeleton products are simply and efficiently prepared. The technology practices outstanding cost reduction and efficiency improvement results, and is beneficial to large-scale preparation of high-value chemicals relying on rich coal resources in China.

The present invention discloses a polyaspartic acid composition comprising an asymmetric polyaspartic acid resin. The asymmetric polyaspartic acid resin is a reaction product of an asymmetric aspartic acid composition and an isocyanate chain extender. The asymmetric aspartic acid composition is a reaction product of a multifunctional acrylate component, at least one butenedioic acid dialkyl ester, and a multifunctional primary amino compound. Also disclosed is a multi-resin form of a polyaspartic acid composition. The multi-resin polyaspartic acid compositions include at least two different asymmetric polyaspartic acid resin variants. Also disclosed are a method of preparing the polyaspartic acid composition, as well as a coating composition comprising the polyaspartic acid composition, a method of preparing a coated article using the coating composition, and a coated article prepared thereby.

The present invention provides a cooking aid, a preparation method, and an application thereof, which belong to the field of papermaking and pulping. The cooking aid is prepared from the following raw materials in parts by weight: 50 to 75 parts of a dispersant, 35 to 90 parts of a penetrant, 10 to 30 parts of a degreasing agent, and 100 to 120 parts of water; the dispersant is prepared from water, acrylic acid, maleic anhydride, 2-acrylamido-2-methylpropanesulfonic acid, and an initiator; or the dispersant is prepared from water, allyl polyoxyethylene ether, sodium α-olefin sulfonate, 2-acrylamido-2-methylpropanesulfonic acid, and an initiator. The cooking aid prepared by the present invention can meet the production requirements of manufacturers, exceeding the manufacturer's requirements in terms of alkali consumption, KP value, pulp board whiteness, chlorine dioxide dosage, hydrogen peroxide dosage, and resin control agent dosage.

The present invention belongs to the field of oil extraction technology, and specifically relates to a fracturing drag reducer and a preparation method thereof. The preparation method is as follows: perfluorooctylethyl acrylate, (3-acryloxypropyl) tris(trimethylsiloxy) silane, 3-[N,N-dimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]ammonium] propane-1-sulfonic acid inner salt, butenedioic acid, TX-10, MS-1, carboxymethyl cellulose, buffer salt, and distilled water are sequentially added to a reactor to adjust the pH to 7-8; the reactor and pipeline are purged with nitrogen, an initiator is added dropwise to the reactor, the addition is completed, heating, insulation reaction, continued reaction, then heating, insulation reaction, cooling to below 40°C, adjusting the pH to 7-8, and obtaining a product fracturing drag reducer. The present invention has the advantages of a wide source of raw materials, a simple synthesis process, and no by-products; at the same time, the present invention has the characteristics of high apparent viscosity and high drag reduction rate.

The invention provides a butenedioic acid ester biquaternary ammonium salt compound as well as a pharmaceutical composition and application of the butenedioic acid ester biquaternary ammonium salt compound. Specifically provided are a compound V, a pharmaceutically acceptable salt thereof, a solvate thereof, a metabolite thereof, a tautomer thereof or a prodrug thereof, the compound V comprising a compound represented by formula I and a pharmaceutically acceptable anion. The compound provided by the invention is good in activity and has a relatively good application prospect.

The invention provides a method for preparing succinate and butenedioic acid ester by synergistically catalyzing acetylene double carbonylation through double ligands, which is characterized in that acetylene, carbon monoxide and an alcohol compound are used as raw materials and are subjected to one-step reaction in an organic solvent through a specific catalyst system. The catalyst system is composed of a palladium-based catalyst, a halide auxiliary agent, an acid auxiliary agent, an electron-withdrawing sulfur ligand and an optional second ligand, wherein the second ligand is a phosphorus-containing or nitrogen-containing ligand. The core innovation of the invention lies in that a double-ligand synergistic catalytic system of an electron-withdrawing sulfur ligand and an electron-donating second ligand is constructed, a catalytic path is significantly optimized through an electron and space synergistic effect, and succinate is efficiently and highly selectively prepared under mild conditions. The method has the advantages of mild reaction conditions, simple operation, high catalyst stability and activity, significantly improved target product selectivity, and good industrial application prospects.

The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)- or cis (Z)-butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxic agent, and / or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.

The application provides an acrylic metal salt resin containing rosin and rosin-derived quaternary ammonium salt and a preparation method and application thereof, and relates to the technical field of organic polymer materials. The acrylic metal salt resin is prepared by the following preparation method: rosin, maleic anhydride, p-toluenesulfonic acid and acetic acid are mixed and heated to reflux to obtain maleopimaric acid; maleopimaric acid, alcohol and N, N-dimethylethylenediamine are mixed and heated to obtain a product precursor; the product precursor is mixed with tetrahydrofuran and bromoethane to obtain rosin-derived quaternary ammonium salt; acrylic ester monomers, acrylic acid and methacrylic acid are mixed to obtain a monomer mixture; the monomer mixture is mixed with an initiator, a solvent and a chain transfer agent to carry out polymerization and obtain a resin prepolymer; and then a metal-containing compound, rosin, a small-molecule organic acid, a solvent and rosin-derived quaternary ammonium salt are mixed to obtain the acrylic metal salt resin with antibacterial and anti-protein adsorption properties.

The utility model discloses a maleic anhydride tail gas purification system and the system of preparation maleic anhydride relates to the technical field of chemical production. Including first washing tower, compression unit, heat exchange device and second washing tower that are connected in turn, and the outlet of second washing tower and the inlet of gas -gas heat exchange medium passage of heat exchange device form loop, and the outlet of gas -gas heat exchange medium passage is configured as with maleic anhydride reaction system through pipeline intercommunication, to make maleic anhydride tail gas flow through first washing tower, compression unit, heat exchange device and second washing tower in proper order, and after two times washing, after heat exchange in heat exchange device, exhaust. The system not only can recycle and utilize the n-butane that is not completely reacted in maleic anhydride tail gas, reduces the loss of n-butane, improves economic efficiency, and can avoid organic acid and other byproducts and n-butane return to reactor system together, avoids equipment corrosion, improves system safety. Simultaneously through to the effective utilization of heat, has the effect of energy -conserving and loss -reducing.

Provided is a copolymer rubber obtained by copolymerizing a butenedioic acid diester structure-containing monomer represented by general formula (1) and a radically polymerizable monomer. (In general formula (1), R1 represents an alkyl group having 1-4 carbon atoms; r2 represents a group represented by R7 or OR8; r7 represents an optionally substituted alkyl group having 1 to 8 carbon atoms; r8 represents an optionally substituted alkyl group having 1 to 8 carbon atoms or an optionally substituted polyalkylene glycol group; r3, R4 and R6 are each independently a hydrogen atom or an alkyl group having 1-4 carbon atoms; r5 represents a hydrogen atom, a group represented by R7 or OR8; when R3 is a hydrogen atom, R2 is a group represented by OR8; r1 and R2 can be bonded to each other to form a ring; r4 and R5 can be bonded to each other to form a ring. > # imgabs0 #

The application relates to the technical field of perovskite photovoltaics, and discloses a polysiloxane polymer and a preparation method thereof, a perovskite thin film and a preparation method and application thereof, and a solar cell and application thereof. The polysiloxane polymer has a three-dimensional branched molecular structure and can realize chelation in multiple directions and multiple tooth sites. The preparation method comprises the following steps: in the presence of an inert atmosphere, tetraethyl orthosilicate and butenedioic acid are subjected to ester exchange polycondensation reaction to obtain a multi-tooth chelated hyperbranched polysiloxane polymer. In addition, the multi-tooth chelated hyperbranched polysiloxane polymer can be introduced into a perovskite thin film bulk phase, so that the defects of a perovskite material can be more effectively passivated, and the improvement of the efficiency and stability of a perovskite solar cell is further realized.

The invention relates to the technical field of polycarboxylate surfactants containing tocopherol, and discloses a polycarboxylate surfactant containing tocopherol and application of the polycarboxylate surfactant in pesticides. Trans-1, 4-dichloro-2-butene, diethanol amine, phosphorus pentoxide and the like are used as raw materials, and an alkene-containing tetraphosphate intermediate is obtained through a substitution reaction and an esterification reaction. DL-alpha-tocopherol, maleic anhydride, polyethylene glycol and the like are used as raw materials, tocopherol modified polyethylene glycol is obtained through two-step reaction, an alkenyl structure contained in the tocopherol modified polyethylene glycol and raw materials such as acrylic acid and an alkene-containing tetraphosphate intermediate are copolymerized, and the polycarboxylate surfactant containing the tocopherol is obtained. When the prepared polycarboxylate surfactant containing tocopherol is applied to pesticides, the suspension effect and the heat storage stability of a pesticide water suspension agent can be improved.

The invention provides high-acid-value polyester for a 70 / 30 mixed powder coating as well as a preparation method and application of the high-acid-value polyester, and belongs to the technical field of powder coatings. The polyester resin is obtained through polymerization of 1, 3-propylene glycol, xylitol, terephthalic acid, 1, 4-succinic acid, triethylene glycol dimethacrylate, 2-allyl cyclohexanone, acrylic acid and maleic anhydride, the high-acid-value polyester resin with insufficient compatibility of self molecular chain segments is obtained, the functionality is improved through introduction of xylitol, and the functionality is improved; the introduction of 2-allyl cyclohexanone improves the water resistance of the product, the triethylene glycol dimethacrylate improves the adhesive force of a coating film and a metal substrate, and the introduction of acrylic acid and butenedioic anhydride as active carboxyl not only improves the curing activity, but also increases the difference of carboxyl curing. The dry-mixing matting effect with the conventional 70 / 30 mixed powder coating is favorably realized.

The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)- or cis (Z)-butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxic agent, and / or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.

The application provides a concrete water reducing agent and a preparation method thereof and belongs to the technical field of water reducing agents. Modified chitin, 1-vinyl-3-butyl imidazole trifluoromethane sulfonate, a silane coupling agent with a double bond, methacrylic acid, trans-butenedioic acid and an initiator are added into dimethylformamide, heated and stirred to react, toluene is removed under reduced pressure, and the concrete water reducing agent is prepared through alkali washing and alcohol washing; the modified chitin is prepared through modification of chitin by sodium sulfonate and acrylic acid and then by tannic acid. The polycarboxylic acid water reducing agent prepared by copolymerization of the modified chitin, the 1-vinyl-3-butyl imidazole trifluoromethane sulfonate, the silane coupling agent with the double bond, the methacrylic acid and the trans-butenedioic acid has a comb-shaped structure, a plurality of active groups with strong polarity on a main chain and hydrophilic active groups on side chains, and has the characteristics of low mixing amount, high water reducing rate, high reinforcing effect, high plastic retention and volume stability, and has a wide application prospect.

The application relates to the field of pouring sealant, and discloses a modified epoxy resin pouring sealant and a preparation method thereof. The pouring sealant comprises an epoxy resin, modified inorganic fillers, modified additives and an auxiliary agent. The modified inorganic fillers are prepared by grafting quaternary ammonium s-triazine derivatives onto inorganic fillers. The quaternary ammonium s-triazine derivatives are prepared by sequentially substituting 3,5-diaminophenyl boronic acid, cyanuric chloride and 3-chloropropyl trimethoxysilane with 1,4-butanediamine, and then reacting with N,N-dimethyl-1,3-diaminopropane and quaternized by bromoethane. The modified additives are prepared by using modified bismaleimide monomers prepared from maleic anhydride and 5(6)-amino-1-(4-aminophenyl)-1,3,3-trimethylindane and 1-methyl-4-isopropyl cyclohexene by self-stabilizing precipitation polymerization. The pouring sealant prepared by the application has high tensile strength, good impact resistance, good heat resistance, good flame retardance, good dielectricity and good bacteriostasis.

The disclosure relates to 2-(5-hydroxy-1H-indol-3-yl)ethan-1-aminium hydrate chloride (5-HT hydrochloride hydrate) and its crystalline form 1, and to pharmaceutical compositions containing 5-HT hydrochloride hydrate or its crystalline form 1 and to methods of treatment using them. The disclosure further relates to crystalline form 1 of (2E)-but-2-enedioic acid bis({2-[4-(acetyloxy)-1H-indol-3-yl]ethyl}(ethyl)propylazanium) (2E)-but-2-enedioate (4-AcO-EPT fumarate fumaric acid), and to pharmaceutical compositions containing crystalline form 1 of 4-AcO-EPT fumarate fumaric acid and to methods of treatment using it. The disclosure further relates to [2-(1H-indol-3-yl)ethyl](methyl)propylazanium iodide (MPT iodide) and its crystalline form 1, and to pharmaceutical compositions containing MPT iodide or its crystalline form 1 and to methods of treatment using them. The disclosure further relates to bis(ethyl[2-(1H-indol-3-yl)ethyl]propylazanium) (2E)-but-2-enedioate (EPT fumarate) and its crystalline form 1, and to pharmaceutical compositions containing EPT fumarate or its crystalline form 1 and to methods of treatment using them. EPT fumarate is a novel compound and crystalline form.

The invention discloses an ultra-fast and nondestructive testing method for solid cis-trans butenedioic acid, relates to the technical field of testing or analyzing materials by means of measuring chemical or physical properties of the materials, and is suitable for quality control of chemical raw materials and monitoring of an organic synthesis process. Comprising the following steps: taking mixed powder of a cis-isomer and a trans-isomer of butenedioic acid; sequentially carrying out ultrasonic mixing and tabletting forming on the mixed powder, and obtaining a characteristic peak area ratio of a cis-isomer to a trans-isomer of the butenedioic acid by adopting a Raman spectrum; establishing a prediction model; and based on the prediction model, predicting to obtain the mass ratio of the cis-isomer to the trans-isomer of the butenedioic acid in the pretreated powder. According to the method, the high-uniformity sample is constructed by screening to control the particle size and ultrasonic dry mixing, and meanwhile, precise measurement of the mass fraction of the cis-trans isomer mixture is realized by combining precise control of tabletting process parameter pressure.

The present application relates to a kind of maleic anhydride continuous hydrogenation preparation γ-butyrolactone and its preparation method.The prepared maleic anhydride solution and hydrogen are continuously introduced into the fixed bed containing nickel-copper catalyst to carry out hydrogenation reaction, the obtained crude product is introduced into separation column to carry out separation and purification, and γ-butyrolactone is obtained.The purity of the obtained γ-butyrolactone is ≥99.99%, and the rest is impurity;The impurity includes tetrahydrofuran and 1,4-butanediol;The content of tetrahydrofuran is ≤0.003%;The content of 1,4-butanediol is ≤0.004%.

The application discloses a kind of ultrafast and nondestructive detection methods for solid cis-trans-butenedioic acid, it is related to the technical field of testing or analyzing materials by determining the chemical or physical properties of materials, suitable for chemical raw material quality control and organic synthesis process monitoring;Including: taking the mixed powder of cis-isomer and trans-isomer of butenedioic acid;The mixed powder is sequentially ultrasonically mixed, tabletting is formed, and the characteristic peak area ratio of cis-isomer and trans-isomer of butenedioic acid is obtained using Raman spectrum;Establish a prediction model;Based on the prediction model, the mass ratio of cis-isomer and trans-isomer of butenedioic acid in the pretreated powder is predicted.The application realizes the accurate determination of cis-trans-isomer mixture mass fraction by screening control particle size and ultrasonic dry mixing to construct high uniformity sample, while combining the precise control of tabletting process parameters pressure.

The present invention relates to a pharmaceutical combination comprising a first active ingredient which is (R)-5-[3-chloro-4-(2,3-dihydroxy-propoxy)-benz[Z]ylidene]-2-([Z]propylimino)-3-o-tolyl-thiazolidin-4-one or a pharmaceutically acceptable salt thereof and a second active ingredient which is selected from the group consisting of methyl fumarate, dimethyl fumarate, (N,N-diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, and 2-(2,5-dioxopyrrolidin-1-yl)ethyl methyl (2E)but-2-ene-1,4-dioate, or a pharmaceutically acceptable salt thereof.

The present invention relates to a pharmaceutical combination comprising a first active ingredient which is (R)-5-[3-chloro-4-(2,3-dihydroxy-propoxy)-benz[Z]ylidene]-2-([Z]propylimino)-3-o-tolyl-thiazolidin-4-one or a pharmaceutically acceptable salt thereof and a second active ingredient which is selected from the group consisting of methyl fumarate, dimethyl fumarate, (N,N-diethylcarbamoyl)methyl methyl (2E) but-2-ene-1,4-dioate, and 2-(2,5-dioxopyrrolidin-1-yl)ethyl methyl (2E) but-2-ene-1,4-dioate, or a pharmaceutically acceptable salt thereof.