38results about How to "Degradation rate adjustable" patented technology

The invention relates to a degradable drug loading stent and a preparation method of the degradable drug loading stent. The degradable drug loading stent is characterized by comprising a skeleton structure made of a medical degradable metal or an alloy of the metal, a degradable macromolecular transition layer adhered to the surface of the skeleton structure and a drug loading layer. The degradable metal/macromolecular/drug multilayer composite stent provided by the invention has excellent mechanical property, degradable property and biocompatibility, and such drugs as taxol, taxol derivative, actinomycin D, 5-fluorouracil and sirolimus are loaded to the stent to perform active directional treatment on the focus position, so the stent is a functional degradable stent. The degradable multifunctional drug loading stent provided by the invention is suitable for interventional therapy in the blood vessel field and non-blood vessel fields and is especially suitable for interventional therapy of stenosis, obstruction or tumor of such non-blood vessel cavities as esophagus, bile duct, ductus pancreaticus, intestinal tract, urethral canal, trachea and bronchus, etc.

The invention adopts a melt polycondensation method. A few of monomers of C2-5 aliphatic dibasic alcohol, diethylene glycol, polyglycol, fumaric acid, maleic anhydride, lactic acid, glycolic acid, ethanolamine, C2 to C12 aliphatic diamine, glutamic acid, lysine, glycine, etc. are taken as basic materials to be synthesized to obtain non toxic unsaturated polyester-amide resin with adjustable degradation rate and lower cost; wherein, the partial fumaric acid or maleic anhydride can be replaced with phthalic anhydride, isophthalic acid, or adipic acid. The resin yearns for being used as matrix resin of medical bone internal fixation material, tissue engineering scaffold material, bone tissue temporary substitutes, environmental protection type bonding agent, environmental protection type fiberglass reinforced plastics, environmental protection type coating material, disposable tableware, packing material, shopping bags, disposable bags, drug coating or capsule, drug delivery (controlled-release) material, agricultural mulching films, etc., and can be recovered to be utilized.

The invention discloses a cellular silk fibroin porous scaffold, and a preparation method thereof. The method comprises the following steps of: degumming silkworm cocoon serving as a raw material, dissolving, dialyzing, and freeze-drying to obtain silk fibroin; and immersing a negative norm sodium chloride porous body which has a plant tissue structure and serves as a template in a silk fibroin solution, vacuum-drying at room temperature, performing beta treatment, and desalting to obtain the silk fibroin porous scaffold which has a bionic plant tissue cellular pore structure. The porosity of the prepared cellar silk fibroin porous scaffold is more than 80 percent, and the apertures of cellular pores are 50 to 300 mu m; and the cellular silk fibroin porous scaffold is high in biocompatibility, and matter permeability, and good in mechanical property and degradation property and the like. The scaffold is particularly suitable for a tissue engineering technology of peripheral nerve, tendon, ligament and the like which have longitudinal structural tissues, and can be widely applied to in-vitro three-dimension cell culture.

The invention belongs to the fields of packaging materials and packaging products, and relates to a biodegradable high-barrier liquid packaging film. The packaging film concretely sequentially comprises a biodegradable heat seal layer, a barrier layer and a protective layer. The invention also relates to a method for preparing the packaging film, a use of the packaging film, and a packaging product comprising the packaging film.

The invention belongs to the field of packaging materials and packaging products, and relates to a biological degradable compound packaging film and a packaging bag. Particularly, the invention relates to the packaging film which sequentially comprises a biological degradable heat seal layer, a blocking layer and a protection layer. The invention further relates to a method for preparing the packaging film, application of the packaging film, and a packaging product (such as the packaging bag) with the packaging film.

A degradable unsaturated polyester-amidourea resin used for disposable food container, packing material, plastic bag, medicinal coating, capsule and slow-releasing material, etc is prepared from C2-C4 binary alcohol, anti-butenedioic acid or maleic anhydride, and urea through fusing and polycondensating. It can be modified by starch or calcium carbonate powder.

The invention relates to a melt polycondensation method for the synthesis of unsaturated polyester amide urea resin from dipropylene glycol or neopentyl glycol or polyethylene glycol, transbutene dioic acid or maleic anhydride and urea as raw materials. The synthesized unsaturated polyester amide urea resin has the advantages of controllable degradation rate, no toxicity and low cost. The transbutene dioic acid or maleic anhydride can be partially replaced by benzene anhydride, isophthalic acid or adipic acid. The dipropylene glycol or neopentyl glycol or polyethylene glycol can be partially replaced by ethylene glycol or propylene glycol. The resin is used as matrix of fracture internal fixation material, tissue engineering scaffold, bone graft substitute, environment-friendly binder, environment-friendly glass-reinforced plastics, environment-friendly painting, disposable tableware, packaging material, shopping bag, garbage bag, pharmaceutical coating or capsule, pharmaceutical slow-/controlled-release material, agricultural mulch film, etc. furthermore, the resin is recoverable.

The invention relates to a calcium polyphosphate/calcium sulfate complex phase biologic ceramic material and a preparation method thereof. The main phase of the ceramic material consists of calcium sulfate and amorphous calcium polyphosphate or beta calcium polyphosphate. The preparation method comprising the following steps of: selecting the calcium sulfate and amorphous calcium polyphosphate as ingredients, wherein the content of the calcium sulfate is 5 to 45 volume percent; weighing calcium sulfate and amorphous calcium polyphosphate according to a proportion, mixing the materials uniformly, using absolute ethyl alcohol as the medium, ball milling and mixing the materials to slurry materials, drying the mixed slurry materials at 60 to 80 DEG C, pelleting the dried powder by polyving alcohol solution and passing a 40-60 mesh screen, and then dry pressing and forming, wherein the forming pressure is 100 to 200 MPa; calcining a formed sample at 550 to 700 DEG C, keeping the temperature for 2 to 8 hours and then furnace cooling the sample. The method disclosed by the invention composes the calcium polyphosphate and calcium sulfate and ensures the aim of regulating degradation rate possibly in the degradation process of the complex phase ceramics through regulating Ca/P rate. The biologic ceramic can be used as a bone to replace repairing materials.

The invention discloses a tissue engineering bracket imitating intima-media structures and functions of natural blood vessels, and a preparation method of the bracket. The bracket is a porous membranoid substance which is prepared from degradable macromolecules, loaded with growth factors, provided with micron-order grooves in parallel in the surface and is of a nano topological structure on the outer surface. The preparation method comprises the following steps: uniformly stirring nano grains with growth factors and a biologic degradable polymer solution, subsequently casting on a mold surface with the grooves in parallel, freezing and drying to eliminate the solvent, further performing surface treatment and loading the growth factors so as to obtain the tissue engineering bracket. Due to the parallel micron-order groove structure, the surface nano topological structure and the loaded growth factors of the tissue engineering bracket disclosed by the invention, induction and prompting functions on growth and breading of vascular smooth muscle cells, which are similar to those of extracellular matrix of intima-media cells of the natural blood vessels, can be achieved, and the vascular smooth muscle cells are enabled to grow and breed in ordered orientation on the artificial bracket like the intima-media of the natural blood vessels.

The invention belongs to the technical field of bio-based materials, and especially relates to a 3D printing artificial biodegradable cerebral dura mater and a preparation method thereof. The invention provides a three-layer composite structure cerebral dura mater repair material, an artificially synthesized degradable material is utilized as a base material, a bacterial cellulose/. polylactic acid composite membrane is used as a reinforcing layer, a collagen sponge membrane layer is used as a biological membrane, an internal structure of the artificial cerebral dura mater prepared by a 3D printing technique is highly similar to human meninges, and the artificial cerebral dura mater can be directly attached to damaged meninges of a patient to achieve the effect of stitching a wound. Compared with a traditional method, the 3D printing artificial biodegradable cerebral dura mater and the preparation method thereof are more beneficial to growth of dura mater cells, enable the probabilityof adhesion to calvarium skull, and provide a powerful guarantee for repair of the cerebral dura mater and prevention of occurrence of epilepsy.

The invention discloses a composite multilayer and porous scaffold and a preparation method of the scaffold. The konjac glucomannan/artificially synthesized high polymer/hydroxyapatite whisker composite multilayer and porous scaffold is prepared by taking konjac glucomannan, an artificially synthesized high polymer and a hydroxyapatite whisker as raw materials, performing film formation in a layer-by-layer composite superposition manner via flow casting and freezing technologies, and finally performing technologies of freeze-drying, cross linking, cleaning and the like. The method is simple in technology, convenient to operate and stable in yield; the prepared multilayer and porous composite scaffold has the characteristics of good biocompatibility, stability, appropriate aperture and the like; since the scaffold is crosswise composited in a layer-by-layer manner by a konjac glucomannan film, and an artificially synthesized high polymer/hydroxyapatite whisker film; the films of different layers have different ingredients and different degradation rates; further, the degradation rates can be regulated to be matched with a growth rate of a new bone; and therefore, the scaffold has good application prospects in an aspect of cartilaginous tissue implantation.

The invention discloses a biodegradable adhesive prepared by copolymerizing protolysate and urea and formaldehyde. In a preparation process of the adhesive, the bonding strength between the bonding material and a seedling culture substrate as well as the nutrient release speed can be controlled by controlling the urea-formaldehyde molar ratio and the hydrolysis degree and addition amount of the protolysate in the copolymerizing process; the adhesive can be used for bonding and moulding the seedling culture substrate to avoid scattering and root injury of the seedlings in a mechanical transplanting process; and after being compounded with the substrate, the adhesive can be degraded to provide nutrients during the seedling growth and also can serve as a coating slow-release material of nutrient elements to promote the seedling growth.

The invention discloses a skin tissue engineering double-layer film material and a preparation method thereof. The preparation method comprises the steps that degradable materials including chitosan and konjac glucomannan which have the good biocompatibility are adopted as raw materials and prepared into mixed solutions separately, film forming is conducted on the mixed solutions through a tape casting method separately, two layers of films are bonded together by adopting a konjac glucomannan solution with the certain concentration as a bonding agent, and then the chitosan-konjac glucomannan double-layer film material is prepared. The material has the advantages of being simple in preparation process, low in cost, adjustable in degradation rate, good in biocompatibility and the like; early cell experiments and animal experiments show that the double-layer film material can be suitable for organisms and is a degradable multifunctional composite material capable of promoting skin repairing.

The invention belongs to the technical field of ceramic bone scaffold preparation and surface modification, and discloses a 3D printing biphase calcium phosphate scaffold and a preparation method thereof.The preparation method comprises the following steps that hydroxyapatite, beta-tricalcium phosphate, hydroxypropyl methyl cellulose and deionized water are prepared into slurry according to the set mass ratio, and the solid-to-liquid ratio of the slurry is 1: (0.96-1.01); printing a biphase calcium phosphate stent from the prepared slurry by adopting a 3D printing technology, and sintering the printed biphase calcium phosphate stent; performing vacuum soaking on the sintered stent in a chitosan solution to obtain a chitosan surface modified biphase calcium phosphate stent; and placing the dried chitosan surface modified biphase calcium phosphate scaffold in a polydopamine solution, coating, drying, cleaning, and drying again to obtain the chitosan/polydopamine composite surface modified biphase calcium phosphate scaffold.