53results about How to "Degradation time controllable" patented technology

The invention provides a temporary plugging agent for horizontal well water control, and a preparation method and application thereof. The temporary plugging agent for horizontal well water control comprises the following raw materials in parts by weight: 4-15 parts of acrylamide, 0.5-3 parts of polypropylene fiber, 1.5-4 parts of reinforcer, 0.5-1.0 part of composite crosslinking agent, 0.1-0.2 part of initiator and the balance of water, totaling 100 parts. The composite crosslinking agent is a mixture composed of polyethyleneglycol diacrylate and N,N-methylene-bis acrylamide in a mass ratio of 10:(1-4). The preparation method of the temporary plugging agent comprises the following steps: sequentially adding the acrylamide, polypropylene fiber, reinforcer and composite crosslinking agent into water, stirring uniformly, adding the initiator, and standing to react for 1-3 hours, thereby obtaining the temporary plugging agent. The invention also provides application of the temporary plugging agent in horizontal well water control. The temporary plugging agent provided by the invention has the characteristics of high gelling viscosity, controllable degradation time, thorough degradation and the like, can plug the high-permeability zone and implement adjustable degradation time, and can lower the damage to the reservoir.

The invention relates to a preparation method of a hydrogel rapidly crosslinked by enzyme catalysis, and application thereof. A precursor of the hydrogel consists of a mixture (hereinafter referred to as No. 1 solution) of good-biocompatibility macromonomer aqueous solution with an active phenolic hydroxyl unit and dioxygenase aqueous solution which is taken as a catalyst, and the aqueous solution of the precursor can rapidly react to form a 3D polymer cross-linked network after an oxidant (usually low-concentration oxydol, hereinafter referred to as No. 2 solution) is injected. As the No. 1 solution and the No. 2 solution have low-viscosity characteristic, are suitable for being transported and injected, and can rapidly crosslink to form a gel network, the hydrogel can be used for vascular embolization treatment, cancer treatment, family planning operation blocking agents, injectable tissue engineering scaffold materials, soft tissue fillers of human body, controlled release drug carriers, anti-adhesive membranes used in operations and the like after adding one or a plurality of components with specific properties to the No. 1 solution or the No. 2 solution or the gel network.

The invention discloses a polylactic acid-based composite material surgical medical film and a preparation method thereof. By adopting electrostatic spinning equipment and exploring proper technological parameters, different types of polylactic acid-based composite material macromolecular fiber thin films are finally formed and are applied to the field of biomedicine. In addition, by regulating and controlling composition of a macromolecular composite material system and thickness of an electro-spinning thin film, the surgical medical film which has good flexibility, high tensile strength, controllable degradation rate as well as excellent waterproof, antibacterial and air permeable performances is obtained finally. The surgical medical film is applicable to the field of various biomedicines such as healing film, wound surface dressing and anti-adhesion medicine; the medical film not only can be better adhered to tissues and avoid biotoxicity, but also can effectively promote transmission functions of blood, nutrients and growth factors in a human body due to the nature of semipermeable membrane. The process of the invention is simple and environment-friendly; the preparation method is easy to operate, low in cost, applicable to large-scale production and good in controllability, and is expected to be widely applied to various medical fields.

The invention relates to a polylactic acid degradable film with controllable degradable time, belonging to the technical field of medical appliances. The polylactic acid degradable film comprises the following components in percentage by weight: 1%-35% of plasticizer and 65%-99% of polylactic acid, polylactic acid-glycollic acid copolymer, polyglycollic acid-epsilon-caprolactone copolymer, polylactic acid-epsilon-caprolactone copolymer or polylactic acid-glycollic acid-epsilon-caprolactone copolymer, wherein the plasticizer is more than one of citrate ether, glucose monoester ether, fatty acid ester ether, polyethylene glycol 400-2,000, low-molecular weight polylactic acid, glycerol, glycerol triacetate and ethylene glycol monobutyl ether acetate. The manufactured polylactic acid degradable film of the invention has good strength and controllable degradable time, can be used for a human body, such as an anti-adhesion film in a surgical operation, a digestive stent, a biliary stent, a prostate stent, an endovascular stent, an intrauterine stent and a medical appliance fitting, and can be used for preparing the required controllable polylactic acid degradable film according to the clinical requirements.

The invention relates to a liposome calcium sulfate composite nanometer artificial boneware, as well as a preparation method and application thereof. The preparation method comprises the steps of well mixing liposome (1 to 40 percent), calcium sulfate powder (40 to 80 percent) and diluent (10 to 50 percent), curing the materials and then preparing a bone graft substitute containing nanometer liposome. The liposome can carry medicine and can modify surface, has two forms, namely solution and powder, and comprises traditional micromolecule liposome and macromolecule liposome having macromolecule characteristics. The invention can provide an artificial bone material which has nanometer reinforcing effects, function of sustaining and controlling medicine release, controllable degradation time, good biocompatibility and mechanical strength, can induce bone growth in vivo, and is beneficial to the healing of defective areas of bones.

The present invention relates to a method for synthesizing starch microsphere as adsorption agent, and it is characterized by that the starch microsphere can be synthesized at a certain temperature, in a certain reaction time, under the action of high-effective catalyst and surfactant in the dispersing agent, and the whole reaction can be made within 4 hr, and the sphere-forming time is within an hour. Said invented microsphere can be used as medicine carrier, adsorption agent of several substances of perfume compound, etc. reinforcing agent of weight-reducing food and paper and sewage treating agent, etc.

The invention belongs to the field of medical hemostatic materials and particularly relates to a hemostatic material and a preparation method thereof. The hemostatic material is prepared from raw materials in parts by weight as follows: 0.1-1.5 parts of carboxymethyl chitosan, 0.5-2 parts of PVA (polyvinyl alcohol), 0.2-5 parts of a compound toughening substance (named a plasticizing system hereinafter) and 0.5-1.5 parts of an ionic crosslinking agent. The hemostatic material can further comprise 0.5-3 parts by weight of a wide-spectrum hemostatic antibacterial agent. The product has good mechanical elasticity, can realize rapid hemostasis, can be completely degraded, is non-toxic and high in antibacterial property and is applicable to wound hemostasis, preferably body cavity hemostasis and especially applicable to nasal cavity hemostasis.

The invention pertains to the field of preparation of medical supplies, in particular to a preparation method of a medical absorbable membrane. In the method, lactic acid and polyethylene glycol are copolymerized by a method of bulk polymerization so as to obtain the medical absorbable membrane of lactic acid/polyethylene glycol copolymer. The preparation method is characterized in that the lactic acid is poly-DL-lactic acid, the limiting viscosity number of which is 0.2 to 1; the molecular weight of polyethylene glycol is 2000 to 8000 and the proportion of each component is poly-DL-lactic acid of 1 to 99.5 percent and 0.5 to 99 percent of polyethylene glycol; the reaction temperature is 100 to 280 DEG C and the reaction time is 2 to 12 hours. The preparation method of the invention has simple process and low production cost and by adopting the preparation method, the medical absorbable membrane have the advantages of uniform thickness, stable quality, good biocompatibility and reliable degradation in human body and being capable of preventing adhesion caused in the surgical operation.

The invention provides an acidizing temporary plugging agent as well as a preparation method and application thereof. The acidizing temporary plugging agent is prepared from the following raw materials in percentage by mass: 1 to 10 percent of a high polymer material, 19 to 28 percent of a water-soluble monomer, 0.9 to 1.4 percent of a functional monomer, 9 to 15 percent of a nano toughening material, 0.12 to 0.34 percent of a weak cross-linking agent, 0.08 to 0.24 percent of an initiator and the balance of water. The degradation rate of the acidizing temporary plugging agent reaches 99% or above, the degradation time is adjustable, the effective plugging rate reaches 99%, and the construction requirement of the acidizing temporary plugging technology is met. Different cracks can be blocked by adjusting the particle size, and the self-degradable plugging agent is environmentally friendly, self-degradable, easy to flow back and wide in adaptability.

The invention relates to a developing type degradable restoration pancreatic duct bracket, which is prepared from the following ingredients including 50 to 100 weight parts of degradable medical materials A, 0.1 to 50 weight parts of heeling restoration materials B, 0.001 to 0.05 weight part of developing agents C, 0.001 to 0.05 weight part of pancreatitis treating medicine D, or 0.001 to 0.05 weight part of antitumor medicine E. The developing type degradable restoration pancreatic duct bracket has the advantages that the biocompatibility is high; the form and the position of implanting materials can be fast judged; the degrading time is controllable; and in the complicated pancreatic duct rebuilding process, the effects of pressure reduction support, drainage, pancreatic duct heeling facilitation, convenience in pancreatic juice condition observation, postoperative pancreatic ductograph and the like can be achieved.

The invention discloses a degradable ureteral stent and a manufacturing method thereof, belongs to the technical field of medical catheters, and aims to solve the problem in the prior art that an existing ureteral stent cannot be absorbed by a human body and needs to be taken out in an operation. According to the technical scheme, the degradable ureteral stent comprises an outer membrane layer, awoven layer and an inner membrane layer which are made of degradable materials, and the woven layer is formed by weaving two different degradable materials. The degradable ureteral stent is composed of the inner membrane layer, the woven layer and the outer membrane layer which are made of different degradable materials, and by means of the difference of the thermal performance and the degradationspeed of the multi-component degradable materials, the overall mechanical performance of the degradable ureteral stent is improved, and the degradation speed is further increased.

The invention discloses a surface coating capable of degrading magnesium and magnesium alloy and a preparation method thereof, the surface coating comprises an inner layer and an outer layer, the inner layer is a magnesium phosphate salt conversion layer, and the outer layer is a hydroxyapatite coating. The prepared coating is of a double-layer structure, the magnesium phosphate salt conversion layer on the inner layer provides growth sites for the hydroxyapatite coating on the outer layer, the binding force of the coating and a base material is effectively improved, and the binding strength can reach 50 MPa or above; in addition, the thickness of the hydroxyapatite coating is controllable, the degradation time can be adjusted according to needs, and the degradation time of the magnesium alloy implant can be controlled to be 12-18 months.

The invention relates to a developing type degradable ureter repairing stent which is prepared from the following components: 50 to 100 weight parts of a degradable medical material A, 0.01 to 50 weight parts of a healing repairing material B, 0.001 to 0.05 weight part of a developing agent C and 0.001 to 0.05 weight part of an anti-infection medicine D. The developing type degradable ureter repairing stent is extremely high in biocompatibility, and the shape and the position of an implanted material can be quickly judged; the degradation time is controllable; in a complicated ureter reconstruction process, the developing type degradable ureter repairing stent achieves effects of pressure-reducing supporting, drainage, favorability of urethra healing, convenience for observation and postoperative ureter imaging and the like.

The invention discloses a medical degradable multilayer polymer/graphene film material and a preparation method thereof. The method includes firstly attaching a biodegradable polymer to a single-layergraphene/Cu substrate by spin coating or casting; then removing Cu through etching to obtain polymer/single-layer graphene film; and laminating a plurality of layers of the polymer/single-layer graphene film to obtain the multilayer polymer/graphene film. The polymer is good in biocompatibility with graphene and is degradable in vivo, and the degradation time of the disclosed film material can beadjusted and controlled through controlling the number of layers of the polymer/graphene film. In addition, the multilayer polymer/graphene film has high mechanical strength, and is corrosion resistant and antibacterial. The preparation method is simple. The multilayer polymer/graphene film material is expected to be applied in clinical surgical suture supporting materials and surface modification of implants.

The invention relates to the technical field of medicines, and particularly discloses an injection type skin filling composition as well as a preparation method and application thereof. The composition comprises polymer microspheres, a polyethylene glycol derivative and dispersion liquid, the polymer microspheres are polycaprolactone microspheres, the polyethylene glycol derivative is polyethylene glycol-succinimide succinate or polyethylene glycol-succinimide glutaric acid ester, and the dispersion liquid is a polycaprolactone microsphere. The dispersion liquid is prepared from oligopeptide acetate and sodium carboxymethyl cellulose. The composition can achieve the effects of precise targeted positioning and occupied filling at the action position, has no swelling displacement risk, can achieve the targeted immediate filling effect, is high in biocompatibility and good in resolubility, can reduce the inflammatory reaction after material implantation, and is safe and effective in clinical application.

The invention relates to a developing type degradable urethra repairing stent which is prepared from the following components of 50 to 100 weight parts of a degradable medical material A, 0.1 to 50 weight parts of a healing repairing material B, 0.001 to 0.05 weight part of a developing agent C, 0.001 to 0.05 weight part of an anti-hyperuricemia medicine D and 0.001 to 0.05 weight part of vitamins. The developing type degradable urethra repairing stent is extremely high in biocompatibility, and the shape and the position of an implanted material can be quickly judged; the degradation time is controllable; in a complicated urethra reconstruction process, the developing type degradable urethra repairing stent achieves the effects of pressure-reducing supporting, drainage, favorability for urethra healing, convenience for observation and postoperative urethra imaging and the like.