Polymer composite fiber surgical suture line capable of sustaining and controlling release of therapeutic medicaments and preparation method thereof

A composite fiber and surgical suture technology, which is applied in the field of biomedical material preparation, can solve the problems of unsatisfactory mechanical properties of products and limited preparation technology, and achieve the effects of controllable degradation time, improved mechanical strength, and convenient knotting

Inactive Publication Date: 2010-06-09
陈东 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, my country's absorbable sutures still face three major problems: (1) The preparation process is limited, and the mechanical properties of the products are not satisfactory
Surgical sutures with slow and controlled release of therapeutic drugs have not been reported yet

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1. Put 10 -3 g has a hollow silica submicron sphere with an inner core (the particle diameter is 260nm, the shell thickness is 45nm, the mesopore diameter is 5nm, and the specific surface area is 400m 2 / g; kernel size is 145nm) soaked in a concentration of 10 -3 In the cephradine aqueous solution of mmol / L, at a temperature of 4 DEG C, stir for 12 hours, then centrifuge at a temperature of 4 DEG C, wash the resulting solid product with deionized water, and freeze-dry to obtain a hollow carbon dioxide having an inner core loaded with cephradine Silicon submicron spheres.

[0030] 2. Put 10 -3 g hollow silica submicron spheres with an inner core loaded with cephradine were ultrasonically dispersed in an aqueous solution of chitosan with an average molecular weight of 10,000 Daltons, and the final concentration of chitosan was 10 -3 g / ml, the final concentration of hollow silica submicron spheres with inner core loaded with cephradine is 10 -3 g / ml, prepared as a chit...

Embodiment 2

[0034] 1. Put 10 -2 g has a hollow silica submicron sphere with an inner core (the particle size is 1000nm, the shell thickness is 200nm, the mesopore diameter is 50nm, and the specific surface area is 1000m 2 / g; kernel size is 500nm) soaked in a concentration of 10 -2 In the ethanol solution of paclitaxel in mmol / L, the temperature was 4°C and stirred for 12 hours, then centrifuged at 4°C, the resulting solid product was washed with deionized water, and freeze-dried to obtain paclitaxel-loaded hollow core with inner core. Silica submicron spheres.

[0035] 2. Put 10 -2 g Paclitaxel-loaded hollow silica submicron spheres with inner cores were ultrasonically dispersed in an aqueous solution of polylactic acid with an average molecular weight of 200,000 Daltons, and the final concentration of polylactic acid was 10 -2 g / ml, the final concentration of paclitaxel-loaded hollow silica submicron spheres with an inner core is 10 -2 g / ml, prepared as a polylactic acid spinning so...

Embodiment 3

[0039] 1. 1g of hollow silica submicron spheres with inner core (particle size is 500nm, shell thickness is 40nm, mesopore diameter is 10nm, specific surface area is 600m 2 / g; the kernel size is 150nm) soaked in the aqueous solution of epidermal growth factor with a concentration of 1mmol / L, stirred at a temperature of 4°C for 1 week, then centrifuged at a temperature of 4°C, and washed the obtained solid product with deionized water , and freeze-dried to obtain a hollow silicon dioxide submicron sphere with an inner core loaded with epidermal growth factor.

[0040] 2. Ultrasonically disperse 1 g of hollow silica submicron spheres loaded with epidermal growth factor in an aqueous solution of gelatin with an average molecular weight of 20,000 Daltons. The final concentration of gelatin is 0.5 g / ml, loaded with epidermal growth factor The final concentration of the hollow silicon dioxide submicron spheres with an inner core is 1 g / ml, and a gelatin spinning solution containing...

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Abstract

The invention belongs to the field of biomedical materials and relates to a polymer composite fiber surgical suture line capable of sustaining and controlling the release of therapeutic medicaments and a preparation method thereof. Nucleated hollow silicon dioxide submicron spheres containing the therapeutic medicaments are dispersed in aqueous solution of a polymer; the nucleated hollow silicon dioxide submicron spheres containing the therapeutic medicaments are embedded in polymer fibers by using a spinning method to form the polymer composite fiber surgical suture line of the nucleated hollow silicon dioxide submicron spheres embedded and loaded the therapeutic medicaments to obtain the polymer composite fiber surgical suture line capable of sustaining and controlling the release of the therapeutic medicaments. The embedded nucleated hollow silicon dioxide submicron spheres are dispersed in the polymer fibers and filled with the medicaments and has a sustained release function. Themedicaments are released by slow diffusion and the gradual degradation of the polymer fibers. The loaded medicaments have functions of resisting bacteria and inflammation, killing tumor cells remaining after surgery and the like.

Description

technical field [0001] The invention belongs to the technical field of preparation of biomedical materials, and relates to a polymer composite fiber surgical suture capable of sustained and controlled release of therapeutic drugs and a preparation method thereof, in particular to a submicron hollow silicon dioxide with an inner core embedded with therapeutic drugs A surgical suture made of spherical polymer composite fibers and a method for preparing the same. Background technique [0002] At present, the surgical sutures used clinically in China are mainly divided into two types: non-absorbable sutures and absorbable sutures. Non-absorbable sutures include nylon, polypropylene, and polyethylene. These materials are used as surgical sutures with high tensile strength and low tissue response, but the disadvantages are that they are difficult to knot, easy to detach, cannot be degraded and absorbed, and need to be removed. Absorbable sutures include cashmere thread, polyglyc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L17/10
Inventor 陈东张阳德李琳琳唐芳琼周健王苏阳
Owner 陈东
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