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Medical sponge dressing and preparation method thereof

A technology of sponge and composite material, applied in the field of medical sponge dressing and its preparation, can solve the problems of lack of antibacterial efficacy, biocompatibility, and lack of antibacterial properties, achieve lasting and efficient antibacterial effect, promote healing, and sterilize good effect

Active Publication Date: 2014-04-23
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, polyvinyl alcohol medical-grade sponges do not have antibacterial functions, and are less suitable for susceptible or infected wounds. In order to obtain polyvinyl alcohol sponges with antibacterial properties, in the prior art, polyvinyl alcohol sponges are usually soaked in antibacterial In the drug, the antibacterial drug is combined by physical adsorption. Since the antibacterial drug is only physically combined with the polyvinyl alcohol sponge, the drug is easily separated from the carrier, and a good antibacterial effect cannot be achieved; The drug is made into powder or liquid, and then mixed with polyvinyl alcohol materials, foaming agents and cross-linking agents, etc., and then foamed to obtain polyvinyl alcohol sponges with antibacterial properties. Due to the chemical properties of foaming agents and cross-linking agents The impact of the product, the efficacy of antibacterial drugs and the biocompatibility of polyvinyl alcohol sponge will be affected

Method used

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  • Medical sponge dressing and preparation method thereof
  • Medical sponge dressing and preparation method thereof
  • Medical sponge dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] (1) Dissolve the freeze-dried aloe powder in double-distilled water to obtain a 1% aloe aqueous solution, and store it in a 4°C refrigerator for later use;

[0058] (2) A polyvinyl alcohol material with a molecular weight of 60,000 and an alcoholysis degree of 99.9% was dissolved in distilled water at 90°C to obtain an aqueous solution of polyvinyl alcohol with a mass concentration of 10%;

[0059] (3) Mix the aloe aqueous solution obtained in step (1) with the polyvinyl alcohol aqueous solution obtained in step (2) to obtain the first mixed solution, add polyhexamethylene hydrochloric acid to the first mixed solution, and stir evenly to obtain the second mixed solution mixture;

[0060] (4) Inject the second mixed solution into the polytetrafluoroethylene mold, the thickness of the second mixed solution in the polytetrafluoroethylene mold is 50 μm, let stand at 4°C for 4h, then freeze at -80°C for 24h, and then freeze at 25°C Thaw at ℃ for 4 hours to obtain the gel, ...

Embodiment 2

[0065] (1) Dissolve the freeze-dried aloe powder in double-distilled water to obtain a 2% aloe aqueous solution, and store it in a 4°C refrigerator for later use;

[0066] (2) Dissolve polyvinyl alcohol material with a molecular weight of 200,000 and an alcoholysis degree of 88% in distilled water at 90°C to obtain an aqueous solution of polyvinyl alcohol with a mass concentration of 25%;

[0067] (3) Mix the aloe aqueous solution obtained in step (1) with the polyvinyl alcohol aqueous solution obtained in step (2) to obtain the first mixed solution, add polyhexamethylene hydrochloric acid to the first mixed solution, and stir evenly to obtain the second mixed solution mixture;

[0068] (4) Inject the second mixed solution into the polytetrafluoroethylene mold, the thickness of the second mixed solution in the polytetrafluoroethylene mold is 500 μm, let stand at 4°C for 4h, then freeze at -20°C for 4h, and then freeze at -20°C for 4h, and then freeze at 30°C Thaw at ℃ for 1 ...

Embodiment 3

[0070] (1) Dissolve the freeze-dried aloe powder in double-distilled water to obtain a 0.1% aloe aqueous solution, and store it in a 4°C refrigerator for later use;

[0071] (2) Dissolving polyvinyl alcohol with a molecular weight of 100,000 and an alcoholysis degree of 88% in distilled water at 90°C to obtain an aqueous solution of polyvinyl alcohol with a mass concentration of 15%;

[0072] (3) Mix the aloe aqueous solution obtained in step (1) with the polyvinyl alcohol aqueous solution obtained in step (2) to obtain the first mixed solution, add hydroxypropyltrimethylammonium chloride chitosan in the first mixed solution, Obtain the second mixed solution after stirring evenly;

[0073] (4) Inject the second mixed solution into the polytetrafluoroethylene mold, the thickness of the second mixed solution in the polytetrafluoroethylene mold is 200μm, let it stand at 4°C for 8h, then freeze it at -60°C for 12h, and then freeze it at 30°C Thaw at ℃ for 2 hours, repeat freezing...

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Abstract

The invention provides medical sponge dressing. The medical sponge dressing comprises polyvinyl alcohol, aloe vera and an antibacterial agent, wherein the polyvinyl alcohol takes the shape of a three-dimensional mesh, the aloe vera and the antibacterial agent are loaded on the surface and in the polyvinyl alcohol, the polyvinyl alcohol, the aloe vera and the antibacterial agent form a composite material with micropores, and the masses of the polyvinyl alcohol, the aloe vera and the antibacterial agent respectively account for 79-94.5%, 5-20% and 0.5-1% in the total mass of the composite material. The invention also provides a preparation method of medical sponge dressing, which comprises: mixing the polyvinyl alcohol, the aloe vera and the antibacterial agent, freezing and unfreezing to prepare the medical sponge dressing. The medical sponge dressing can absorb a large amount of wound exudate, and meanwhile, has the advantages of being antibacterial and anti-inflammatory, moisturizing and relieving pain, absorbing exudate, preventing adhesion and effectively promoting wound healing, and the like.

Description

technical field [0001] The invention relates to a medical sponge dressing and a preparation method thereof. Background technique [0002] Medical dressings are a type of clinical medical material that temporarily covers burns, ulcers, and wounds. Its main function is to control wound exudate during wound healing and protect the wound from external sources such as bacteria and dust particles. Polyvinyl alcohol (PVA) sponge is a non-fibrous, porous material with stable chemical properties and good biocompatibility, and has excellent hydrophilicity, liquid absorption, blood absorption and good resistance to biodegradation , low cost, and has broad application prospects in the field of medical dressings. [0003] However, polyvinyl alcohol medical-grade sponges do not have antibacterial functions, and are less suitable for susceptible or infected wounds. In order to obtain polyvinyl alcohol sponges with antibacterial properties, in the prior art, polyvinyl alcohol sponges are u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/24A61L15/40A61L15/28A61L15/44
Inventor 朱勇军胡阳王金慧周新周阳潘浩波
Owner SHENZHEN INST OF ADVANCED TECH
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