Hemostatic material and preparation method thereof

A technology of hemostatic materials and raw materials, which can be used in pharmaceutical formulations, bandages, and drug delivery. It can solve the problems of performance improvement, failure of packing to stop bleeding, limited packing pressure, etc., and achieve good solubility and biodegradability, good extrusion hemostasis, The effect of good permeability

Active Publication Date: 2017-10-20
BEIJING TONGREN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] But it also has defects: ①The main component is polyurethane, and its final degradation product is humic acid, commonly known as "corpse poison"
As a result, the product can only be retained in a small amount and needs to be excreted from the body in a short time, so it can only act on the human pipeline system in a short time, such as the body cavity, reproductive tract and other parts
②The polyurethane component does not have hemostatic properties, and can only rely on mechanical elastic compression, so the hemostatic effect is general; ③The material itself has no antibacterial properties
[0013] But it also has defects: 1. the pressure caused by volume expansion after the product absorbs body fluid is limited, and there is a possibility of failure of packing to stop bleeding, and its packing success rate is not as good as that of traditional packing materials such as vaseline packing strips; 2. its raw material polyvinyl alcohol (PVA ) itself has no hemostatic and anti-inflammato

Method used

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  • Hemostatic material and preparation method thereof
  • Hemostatic material and preparation method thereof
  • Hemostatic material and preparation method thereof

Examples

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Example Embodiment

[0046] In the second aspect, the present invention provides a method for preparing a hemostatic material; the preparation method can be achieved by the following two different operations.

[0047] The first preparation method sequentially includes the following steps:

[0048] (1) Dissolution: Dissolve carboxymethyl chitosan and polyvinyl alcohol in water according to the above ratio to obtain the main raw material aqueous solution (the mass percentage concentration is 0.5-5%, which can be 0.5%, 1%, 2%, 3 %、4%、5%)

[0049] (2) Cross-linking: Add a compound toughening compound and an antibacterial agent mixed with polyethylene glycol and glycerin to the main raw material aqueous solution according to the above-mentioned ratio, and perform a cross-linking reaction to obtain a cross-linked product.

[0050] Among them, the mixed system composed of the main raw material aqueous solution, the compound toughening material, and the antibacterial agent is stirred for 15-40 minutes (preferably...

Example Embodiment

[0073] Example 1

[0074] The hemostatic material of this embodiment is prepared by the first method, and the hemostatic material includes the following raw materials in parts by weight ratio:

[0075] Carboxymethyl chitosan 1.4,

[0076] PVA(EG-40) 0.6,

[0077] Compound toughening compound 1.5 (including PEG-2000 1, glycerol 0.5),

[0078] Polyhexamethyleneguanidine 0.5,

[0079] Ferric chloride 1.1.

[0080] The preparation method of this embodiment sequentially includes the following steps:

[0081] To 100 mL of an aqueous solution containing 1.4 g of carboxymethyl chitosan and 0.6 g of PVA (EG-40), add 1.5 g of the compound toughening material and 0.5 g of polyhexamethylene guanidine, and mix well at room temperature. After stirring and foaming for 30 minutes, 10 mL of ferric chloride solution with a concentration of 10% by mass was added, and then put into a mold, pre-frozen at -20°C and thawed at room temperature, and repeated 5 times. The material at -20°C was demolded and immedi...

Example Embodiment

[0082] Example 2

[0083] The hemostatic material of this embodiment is prepared by the first method, and the hemostatic material includes the following raw materials in parts by weight ratio:

[0084] Carboxymethyl chitosan 1.2,

[0085] PVA(EG-40) 0.8,

[0086] Compound toughening compound 1.5 (including PEG-2000 1, glycerol 0.5)

[0087] Polyhexamethyleneguanidine 0.5,

[0088] Ferric chloride 1.1.

[0089] The preparation method of this embodiment sequentially includes the following steps:

[0090] To 100 mL of an aqueous solution containing 1.2 g of carboxymethyl chitosan and 0.8 g of PVA (EG-40), add 1.5 g of compound toughening material and 0.5 g of polyhexamethylene guanidine, and mix well at room temperature. After stirring and foaming for 30 minutes, 10 mL of ferric chloride solution with a concentration of 10% by mass was added, and then put into a mold, pre-frozen at -20°C and thawed at room temperature, repeated 5 times. The material at -20°C was demolded and immediately fre...

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Abstract

The invention belongs to the field of medical hemostatic materials and particularly relates to a hemostatic material and a preparation method thereof. The hemostatic material is prepared from raw materials in parts by weight as follows: 0.1-1.5 parts of carboxymethyl chitosan, 0.5-2 parts of PVA (polyvinyl alcohol), 0.2-5 parts of a compound toughening substance (named a plasticizing system hereinafter) and 0.5-1.5 parts of an ionic crosslinking agent. The hemostatic material can further comprise 0.5-3 parts by weight of a wide-spectrum hemostatic antibacterial agent. The product has good mechanical elasticity, can realize rapid hemostasis, can be completely degraded, is non-toxic and high in antibacterial property and is applicable to wound hemostasis, preferably body cavity hemostasis and especially applicable to nasal cavity hemostasis.

Description

technical field [0001] The invention belongs to the field of medical hemostatic materials, in particular to a hemostatic material and a preparation method thereof. Background technique [0002] Chitosan is a polymer polysaccharide formed after chitin is hydrolyzed to remove part or all of its acetic acid groups under alkaline conditions. Its chemical name is poly(1,4)-2-amino-2-deoxy- β-D-glucose, the structural formula is as follows: [0003] [0004] The structure of the chitosan molecule itself is very complex, with many ionic primary amino groups, which can easily undergo chemical reactions and react with acids to form salts. Therefore, a series of amino reactions can be carried out; at the same time, chitosan and other polysaccharides Similarly, there are reactive hydroxyl groups available in its structure, so it can also be derivatized. Various derivatives of chitosan have different physical and chemical properties and functions due to the difference in molecular ...

Claims

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Application Information

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IPC IPC(8): A61L15/46A61L15/44A61L15/42A61L15/28A61L15/24C08L5/08C08L29/04C08L71/02C08L79/00C08K5/053C08K3/16C08J3/24
CPCA61L15/24A61L15/28A61L15/42A61L15/425A61L15/44A61L15/46A61L2300/404A61L2300/418A61L2400/04C08J3/24C08J2305/08C08J2429/04C08J2471/02C08L5/08C08L2203/02C08L2205/035C08L2312/00C08L29/04C08L71/02C08L79/00C08K5/053C08K3/16
Inventor 王彤臧洪瑞苏志强
Owner BEIJING TONGREN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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