Hemostatic material and preparation method thereof
A technology of hemostatic materials and raw materials, which can be used in pharmaceutical formulations, bandages, and drug delivery. It can solve the problems of performance improvement, failure of packing to stop bleeding, limited packing pressure, etc., and achieve good solubility and biodegradability, good extrusion hemostasis, The effect of good permeability
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[0046] In the second aspect, the present invention provides a method for preparing a hemostatic material; the preparation method can be realized through the following two different operations.
[0047] The first preparation method comprises the following steps in turn:
[0048] (1) Dissolving: Carboxymethyl chitosan and polyvinyl alcohol are dissolved in water according to the above ratio to obtain the main raw material aqueous solution (mass percentage concentration is 0.5-5%, can be 0.5%, 1%, 2%, 3% %, 4%, 5%)
[0049] (2) Cross-linking: According to the above ratio, add a compound toughener and an antibacterial agent mixed with polyethylene glycol and glycerin to the aqueous solution of the main raw materials to carry out a cross-linking reaction to obtain a cross-linked product.
[0050] Wherein, the mixing system composed of the main raw material aqueous solution, compound toughening material and antibacterial agent is stirred for 15-40min (preferably 30min); , its mass...
Embodiment 1
[0074] The hemostatic material of this embodiment is prepared by the first method, and the hemostatic material includes the following raw materials in parts by weight:
[0075] Carboxymethyl Chitosan 1.4,
[0076] PVA (EG-40) 0.6,
[0077] Compound toughener 1.5 (including PEG-2000 1, glycerin 0.5),
[0078] Polyhexamethyleneguanidine 0.5,
[0080] The preparation method of the present embodiment comprises the following steps in turn:
[0081] In the aqueous solution 100mL that contains the carboxymethyl chitosan of 1.4g and 0.6gPVA (EG-40), add the composite toughener of 1.5g and the polyhexamethylene guanidine of 0.5g, mix under room temperature condition, After stirring and foaming for 30 minutes, add 10 mL of ferric chloride solution with a concentration of 10% by mass, then put it into a mold, pre-freeze at -20°C and thaw at room temperature, repeat 5 times. Materials at -20°C were demoulded and immediately freeze-dried for 24 hours. Th...
Embodiment 2
[0083] The hemostatic material of this embodiment is prepared by the first method, and the hemostatic material includes the following raw materials in parts by weight:
[0084] Carboxymethyl chitosan 1.2,
[0085] PVA (EG-40) 0.8,
[0086] Compound toughener 1.5 (including PEG-2000 1, glycerin 0.5)
[0087] Polyhexamethyleneguanidine 0.5,
[0089] The preparation method of the present embodiment comprises the following steps in turn:
[0090] In the aqueous solution 100mL that contains the carboxymethyl chitosan of 1.2g and 0.8gPVA (EG-40), add the composite toughener of 1.5g and the polyhexamethylene guanidine of 0.5g, mix under room temperature condition, After stirring and foaming for 30 minutes, add 10 mL of ferric chloride solution with a concentration of 10% by mass, then put it into a mold, pre-freeze at -20°C and thaw at room temperature, repeat 5 times. Materials at -20°C were demoulded and immediately freeze-dried for 24 hours. The...
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