Hemostatic material and preparation method thereof

Abstract

The invention belongs to the field of medical hemostatic materials and particularly relates to a hemostatic material and a preparation method thereof. The hemostatic material is prepared from raw materials in parts by weight as follows: 0.1-1.5 parts of carboxymethyl chitosan, 0.5-2 parts of PVA (polyvinyl alcohol), 0.2-5 parts of a compound toughening substance (named a plasticizing system hereinafter) and 0.5-1.5 parts of an ionic crosslinking agent. The hemostatic material can further comprise 0.5-3 parts by weight of a wide-spectrum hemostatic antibacterial agent. The product has good mechanical elasticity, can realize rapid hemostasis, can be completely degraded, is non-toxic and high in antibacterial property and is applicable to wound hemostasis, preferably body cavity hemostasis and especially applicable to nasal cavity hemostasis.

Description

technical field

[0001] The invention belongs to the field of medical hemostatic materials, in particular to a hemostatic material and a preparation method thereof. Background technique

[0002] Chitosan is a polymer polysaccharide formed after chitin is hydrolyzed to remove part or all of its acetic acid groups under alkaline conditions. Its chemical name is poly(1,4)-2-amino-2-deoxy- β-D-glucose, the structural formula is as follows:

[0003]

[0004] The structure of the chitosan molecule itself is very complex, with many ionic primary amino groups, which can easily undergo chemical reactions and react with acids to form salts. Therefore, a series of amino reactions can be carried out; at the same time, chitosan and other polysaccharides Similarly, there are reactive hydroxyl groups available in its structure, so it can also be derivatized. Various derivatives of chitosan have different physical and chemical properties and functions due to the difference in molecular ...

Examples

preparation example Construction

[0046] In the second aspect, the present invention provides a method for preparing a hemostatic material; the preparation method can be realized through the following two different operations.

[0047] The first preparation method comprises the following steps in turn:

[0048] (1) Dissolving: Carboxymethyl chitosan and polyvinyl alcohol are dissolved in water according to the above ratio to obtain the main raw material aqueous solution (mass percentage concentration is 0.5-5%, can be 0.5%, 1%, 2%, 3% %, 4%, 5%)

[0049] (2) Cross-linking: According to the above ratio, add a compound toughener and an antibacterial agent mixed with polyethylene glycol and glycerin to the aqueous solution of the main raw materials to carry out a cross-linking reaction to obtain a cross-linked product.

[0050] Wherein, the mixing system composed of the main raw material aqueous solution, compound toughening material and antibacterial agent is stirred for 15-40min (preferably 30min); , its mass...

Embodiment 1

[0074] The hemostatic material of this embodiment is prepared by the first method, and the hemostatic material includes the following raw materials in parts by weight:

[0075] Carboxymethyl Chitosan 1.4,

[0076] PVA (EG-40) 0.6,

[0077] Compound toughener 1.5 (including PEG-2000 1, glycerin 0.5),

[0078] Polyhexamethyleneguanidine 0.5,

[0079] ferric chloride 1.1.

[0080] The preparation method of the present embodiment comprises the following steps in turn:

[0081] In the aqueous solution 100mL that contains the carboxymethyl chitosan of 1.4g and 0.6gPVA (EG-40), add the composite toughener of 1.5g and the polyhexamethylene guanidine of 0.5g, mix under room temperature condition, After stirring and foaming for 30 minutes, add 10 mL of ferric chloride solution with a concentration of 10% by mass, then put it into a mold, pre-freeze at -20°C and thaw at room temperature, repeat 5 times. Materials at -20°C were demoulded and immediately freeze-dried for 24 hours. Th...

Embodiment 2

[0083] The hemostatic material of this embodiment is prepared by the first method, and the hemostatic material includes the following raw materials in parts by weight:

[0084] Carboxymethyl chitosan 1.2,

[0085] PVA (EG-40) 0.8,

[0086] Compound toughener 1.5 (including PEG-2000 1, glycerin 0.5)

[0087] Polyhexamethyleneguanidine 0.5,

[0088] ferric chloride 1.1.

[0089] The preparation method of the present embodiment comprises the following steps in turn:

[0090] In the aqueous solution 100mL that contains the carboxymethyl chitosan of 1.2g and 0.8gPVA (EG-40), add the composite toughener of 1.5g and the polyhexamethylene guanidine of 0.5g, mix under room temperature condition, After stirring and foaming for 30 minutes, add 10 mL of ferric chloride solution with a concentration of 10% by mass, then put it into a mold, pre-freeze at -20°C and thaw at room temperature, repeat 5 times. Materials at -20°C were demoulded and immediately freeze-dried for 24 hours. The...

technical field

[0001] The invention belongs to the field of medical hemostatic materials, in particular to a hemostatic material and a preparation method thereof. Background technique

[0002] Chitosan is a polymer polysaccharide formed after chitin is hydrolyzed to remove part or all of its acetic acid groups under alkaline conditions. Its chemical name is poly(1,4)-2-amino-2-deoxy- β-D-glucose, the structural formula is as follows:

[0003]

[0004] The structure of the chitosan molecule itself is very complex, with many ionic primary amino groups, which can easily undergo chemical reactions and react with acids to form salts. Therefore, a series of amino reactions can be carried out; at the same time, chitosan and other polysaccharides Similarly, there are reactive hydroxyl groups available in its structure, so it can also be derivatized. Various derivatives of chitosan have different physical and chemical properties and functions due to the difference in molecular ...

Examples

preparation example Construction

[0046] In the second aspect, the present invention provides a method for preparing a hemostatic material; the preparation method can be realized through the following two different operations.

[0047] The first preparation method comprises the following steps in turn:

[0048] (1) Dissolving: Carboxymethyl chitosan and polyvinyl alcohol are dissolved in water according to the above ratio to obtain the main raw material aqueous solution (mass percentage concentration is 0.5-5%, can be 0.5%, 1%, 2%, 3% %, 4%, 5%)

[0049] (2) Cross-linking: According to the above ratio, add a compound toughener and an antibacterial agent mixed with polyethylene glycol and glycerin to the aqueous solution of the main raw materials to carry out a cross-linking reaction to obtain a cross-linked product.

[0050] Wherein, the mixing system composed of the main raw material aqueous solution, compound toughening material and antibacterial agent is stirred for 15-40min (preferably 30min); , its mass...

Embodiment 1

[0074] The hemostatic material of this embodiment is prepared by the first method, and the hemostatic material includes the following raw materials in parts by weight:

[0075] Carboxymethyl Chitosan 1.4,

[0076] PVA (EG-40) 0.6,

[0077] Compound toughener 1.5 (including PEG-2000 1, glycerin 0.5),

[0078] Polyhexamethyleneguanidine 0.5,

[0079] ferric chloride 1.1.

[0080] The preparation method of the present embodiment comprises the following steps in turn:

[0081] In the aqueous solution 100mL that contains the carboxymethyl chitosan of 1.4g and 0.6gPVA (EG-40), add the composite toughener of 1.5g and the polyhexamethylene guanidine of 0.5g, mix under room temperature condition, After stirring and foaming for 30 minutes, add 10 mL of ferric chloride solution with a concentration of 10% by mass, then put it into a mold, pre-freeze at -20°C and thaw at room temperature, repeat 5 times. Materials at -20°C were demoulded and immediately freeze-dried for 24 hours. Th...

Embodiment 2

[0083] The hemostatic material of this embodiment is prepared by the first method, and the hemostatic material includes the following raw materials in parts by weight:

[0084] Carboxymethyl chitosan 1.2,

[0085] PVA (EG-40) 0.8,

[0086] Compound toughener 1.5 (including PEG-2000 1, glycerin 0.5)

[0087] Polyhexamethyleneguanidine 0.5,

[0088] ferric chloride 1.1.

[0089] The preparation method of the present embodiment comprises the following steps in turn:

[0090] In the aqueous solution 100mL that contains the carboxymethyl chitosan of 1.2g and 0.8gPVA (EG-40), add the composite toughener of 1.5g and the polyhexamethylene guanidine of 0.5g, mix under room temperature condition, After stirring and foaming for 30 minutes, add 10 mL of ferric chloride solution with a concentration of 10% by mass, then put it into a mold, pre-freeze at -20°C and thaw at room temperature, repeat 5 times. Materials at -20°C were demoulded and immediately freeze-dried for 24 hours. The...

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