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Chitosan-nanofiber hemostatic material and preparation method thereof

A technology of chitosan nano and hemostatic materials, applied in the direction of fiber processing, fiber chemical characteristics, conjugated synthetic polymer artificial filaments, etc., can solve the problems of poor solubility, poor hydrophilicity, and affect the hemostatic effect, and achieve high efficiency , good fibrosis, simple and quick preparation method

Inactive Publication Date: 2014-01-15
南通南京大学材料工程技术研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the hydrophilicity of chitosan material is relatively poor, and the solubility is also relatively poor, so the amount used in the hemostatic material should not be too high, thus affecting its hemostatic effect

Method used

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  • Chitosan-nanofiber hemostatic material and preparation method thereof
  • Chitosan-nanofiber hemostatic material and preparation method thereof
  • Chitosan-nanofiber hemostatic material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Add 0.2 g of chitosan to 20 mL of 2% acetic acid, and dissolve 0.2 g of polyvinyl alcohol in 10 mL of distilled water.

[0031] Above-mentioned chitosan solution and polyvinyl alcohol solution are carried out electrospray, electrospray condition is as follows: electrospray voltage 10KV, receiving distance 20cm, internal and external pushing speed ratio 2ml / h:4ml / h, the product that collects after electrospray 1h, Vacuum-dried for 24 hours, weighed and sealed for storage, the fiber diameter was 1520 nanometers.

Embodiment 2

[0033] Add 0.2 g of chitosan to 20 mL of 2% acetic acid, and dissolve 0.2 g of polyvinyl alcohol in 10 mL of distilled water.

[0034] Above-mentioned chitosan solution and polyvinyl alcohol solution are carried out electrospray, electrospray condition is as follows: electrospray voltage 15KV, receiving distance 20cm, internal and external pushing speed ratio 2ml / h:4ml / h, the product that collects after electrospray 1h, Vacuum-dried for 24 hours, weighed and sealed for storage, the fiber diameter was 1040 nanometers.

Embodiment 3

[0036] Add 0.2 g of chitosan to 20 mL of 2% acetic acid, and dissolve 0.2 g of polyvinyl alcohol in 10 mL of distilled water.

[0037] Above-mentioned chitosan solution and polyvinyl alcohol solution are carried out electrospray, electrospray condition is as follows: electrospray voltage 20KV, receiving distance 20cm, internal and external pushing speed ratio 2ml / h:4ml / h, the product that collects after electrospray 1h, Vacuum-dried for 24 hours, weighed and sealed for storage, the fiber diameter was 830 nanometers.

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Abstract

The invention provides a chitosan-nanofiber hemostatic material and a preparation method thereof. The chitosan-nanofiber hemostatic material is a core-shell nanofiber, wherein chitosan forms the shell of the nanofiber, polyvinyl alcohol forms the core of the nanofiber, and the diameter of the core-shell nanofiber is 100nm-20Mum. According to the invention, a coaxial electrospinning technology is adopted to prepare the nanometer material with a chitosan-polyvinyl alcohol (CS-PVP) core-shell structure, and the nanometer material has high chitosan content and a high specific surface and is used for hemostasis on living organisms. Experiments prove that the chitosan-polyvinyl alcohol nanofiber, provided by the invention, has good biocompatibility and excellent hemostasis performance, reserves the good water-absorption and fiber forming property of a PVP material, combines the excellent antibacterial hemostasis performance of a CS material, and can be clinically used for wound hemostasis. The preparation method is simple and fast, and has high efficiency.

Description

technical field [0001] The invention relates to the technical field of medical hemostatic auxiliary materials, in particular to a chitosan nanofiber hemostatic material and a preparation method thereof. Background technique [0002] Hemostasis is an important step in medical treatment. Sufficient hemostasis is required for damage to the liver, spleen and other tissues and organs of patients and surgery. When sudden trauma occurs in daily life, rapid hemostasis is also required. In harsh war environments and complex emergencies It is particularly important to achieve rapid and effective hemostasis in the first aid treatment of trauma in the event. At present, the hemostatic materials on the market mainly include fibrin glue, collagen (such as gelatin sponge), and microporous inorganic materials. However, these materials also have some disadvantages, such as: high cost, poor tissue adhesion, and limited hemostatic effect; and porous materials will release a large amount of he...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/24A61L15/44D01D5/00D01F8/18D01F8/10
Inventor 胡勇
Owner 南通南京大学材料工程技术研究院
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