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Photo-cured degradable polyester composite guided bone regeneration membrane

A technology that guides bone regeneration and degrades polyester. It is applied in tissue regeneration, medical science, and prostheses. It can solve the problems of increasing the risk of infection in the surgical area, increasing patient pain and economic burden, and the lack of plasticity of the bone regeneration membrane. Problems, achieve controllable degradation time, improve bone regeneration ability, and have no residual effects in the body

Active Publication Date: 2021-10-29
PEKING UNIV SCHOOL OF STOMATOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the currently used collagen membranes have problems such as rapid degradation and insufficient support strength.
[0003] In order to increase the support performance of the guided bone regeneration membrane, titanium mesh, polytetrafluoroethylene membrane or the combination of the two will be used. Although these guided bone regeneration membranes have the function of support and barrier, these materials are not degradable and must be processed twice. The removal of the operation increases the risk of infection in the operation area and the pain of the patient
In addition, there are also some biodegradable guided bone regeneration membranes, such as polylactic acid and biodegradable polyester, etc., but these polymer guided bone regeneration membranes are not plastic at present, cannot fully adapt to the shape of bone defects, and are not easy to fix and difficult to operate. It is usually necessary to use membrane nails to provide mechanical retention during the operation, which prolongs the operation time and increases the risk of infection, and also increases the patient's pain and economic burden. These deficiencies limit the widespread use of this type of guided bone regeneration membrane

Method used

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  • Photo-cured degradable polyester composite guided bone regeneration membrane
  • Photo-cured degradable polyester composite guided bone regeneration membrane
  • Photo-cured degradable polyester composite guided bone regeneration membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A photocurable polycaprolactone composite guided bone regeneration film, wherein the mass ratio of magnesium powder and methacrylated polycaprolactone is 1:20, and the photoinitiator is 2,4,6-trimethylbenzyl Ethyl acylphenyl phosphonate, the mass ratio of photoinitiator to biodegradable polyester is 0.1:100, the coating ratio of methacrylated polycaprolactone and collagen is 50mg / cm 2 , The thickness of the polycaprolactone composite guiding bone regeneration membrane is 0.50mm, the surface is dense and non-porous, and the elastic modulus is 241.33±27.01MPa.

[0034] Preparation method see figure 1 , including the following steps:

[0035] ①Heat methacrylylated polycaprolactone to a molten state in a constant temperature water bath at 37°C, add photoinitiator 2,4,6-trimethylbenzoylphenylphosphonic acid ethyl ester, photoinitiator and The mass ratio of the biodegradable polyester is 0.1:100, the oscillator oscillates at a speed of 1000rmp, and the time is 15 minutes; t...

Embodiment 2

[0039] Example 2 Performance Test Method of Photocured Polycaprolactone Composite Guided Bone Regeneration Membrane

[0040] Dimensions: Measured with general measuring tools or special measuring tools, the thickness shall be measured according to the method specified in GB / T 6672-2001.

[0041] Mechanical strength: Measured according to the method specified in GB / T 130221991.

[0042] Electron micrographs of photocured polycaprolactone composite guided bone regeneration membrane figure 2 .

[0043] The thickness of the light-cured polycaprolactone composite guiding bone regeneration film can be adjusted according to the coating film ratio, the thickness is 0.30-0.60mm, and the elastic modulus is 241.33±27.01MPa.

Embodiment 3

[0044] Embodiment 3 Animal experiments

[0045] The sample obtained in Example 1 is used for rat skull defect test

[0046] Six healthy 8-week-old SD rats, male, were randomly divided into 2 groups, 3 in each group. All SD rats were raised in an SPF laboratory, ate normally, drank water freely, and adopted preoperative adaptive feeding.

[0047] After the experimental animals were anesthetized by intravenous injection, they were disinfected, the skin was cut open, and the skull was exposed. A bone defect (6mm in diameter) was prepared on the skull with a bone drill, and the photocured polycaprolactone composite guided bone regeneration film was covered on the bone defect area. (smooth side up, rough side down), moderate shaping, light curing, suturing, disinfection.

[0048] Among the two groups of animals, one group of animals was the experimental group, and the skull defect was covered with light-cured polycaprolactone composite guided bone regeneration membrane, which was...

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Abstract

The invention discloses a photo-cured degradable composite guided bone regeneration membrane as well as a preparation method and application thereof. The guided bone regeneration membrane consists of biodegradable polyester, collagen, magnesium powder or zinc powder and a photoinitiator, wherein the collagen is fully soaked by the biodegradable polyester and then forms an interpenetrating network structure with the collagen, and the guided bone regeneration membrane has good shaping property before photo-curing and can adapt to the form of bone defects; after photo-curing, the degradable composite guided bone regeneration membrane has certain supporting performance and can maintain a space required by bone regeneration; meanwhile, the collagen membrane is wrapped by the biodegradable polyester, so that the degradation speed of the collagen is reduced, the action time of the guided bone regeneration membrane is prolonged, and sufficient time is provided for bone repair; and the addition of the magnesium powder or the zinc powder can promote the improvement of the biocompatibility of a material and improve the bone regeneration promoting capacity of the guided bone regeneration membrane. The guided bone regeneration membrane is a novel guided bone regeneration membrane which has supporting and barrier effects and can promote bone tissue regeneration.

Description

technical field [0001] The invention relates to the preparation technology of guided bone regeneration membrane, in particular to a light-cured degradable polyester composite guided bone regeneration membrane and its preparation method and application. Background technique [0002] Oral periodontal and implant surgery often require the application of guided bone regeneration technology, in which the key material is guided bone regeneration membrane, and collagen membrane is a widely used membrane material in guided bone regeneration technology. The main component of collagen membrane is collagen, which is extracellular matrix, has good biocompatibility, and has a certain ability to promote proliferation, adhesion and differentiation of osteoblasts. Collagen membrane can prevent the rapidly proliferating fibroblasts and epithelial cells from invading the bone defect area and produce competitive inhibition with osteoblasts, which is beneficial to the proliferation of osteoblas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/24A61L27/04A61L27/58A61L27/50
CPCA61L27/18A61L27/24A61L27/047A61L27/58A61L27/50A61L2430/02A61L2430/12C08L67/04
Inventor 刘云松徐永祥王飞龙夏丹丹周永胜
Owner PEKING UNIV SCHOOL OF STOMATOLOGY
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