75 results about "Skull defect" patented technology

The invention discloses a method for preparing a to-be-repaired skull flap by 3D printing. The method comprises the following steps: three-dimensionally scanning an original flap at a to-be-repaired skull defect part to obtain the three-dimensional data of surface points of an original flap entity; generating a skull flap three-dimensional model matched with the original flap; forming 8-16 drainage holes in the model and circumferentially and uniformly arranging a plurality of tabs protruding from the skull flap edge along the skull flap three-dimensional model; taking medical photosensitive resin as a raw material, and printing the raw material by a 3D printer to obtain a medical resin flap; finally, fixing the resin flap and the to-be-repaired skull by a tapping screw. Through adoption of the method, the medical resin flap matched with the height of the skull defect window of a patient can be prepared, secondary molding is not required in operation, and the operation time is shortened. The medical resin flap is light in weight, solid, excellent in impact resistance, low in heat-conducting property, and heat-insulating, and reduces discomfort caused after head operation.

The skull patch making process includes the following steps: computerized tomographic imaging to acquire the information of the skull defect part of the patient and the peripheral soft tissue, image designing to reconstruct the 3D head prototype of the patient, designing the dummy for the defect part, leading the designed dummy camber into fast laser forming machine for making patch mold, and final jointing, comparing and cutting titanium web plate to form the ultimate skull patch. The present invention has high precision, low cost, short making period and excellent post-operational restoring.

The invention relates to a mineralized collagen-based skull defect restoration based on digital reconstruction and a preparation method of the skull defect restoration. The preparation method comprises the following steps: acquiring skull image data of a patient; conducting threshold setting and a region growing operation, so that a three-dimensional skull model is obtained; establishing a curve model which is matched with a part of skull defect and has an internal repair curve and an external repair curve; leading the curve model into digital model engraving software and conducting detail treatment; suturing the internal repair curve and the external repair curve into an enclosed solid, so that a restoration model is constituted, and conducting a Boolean operation on the restoration model and the three-dimensional skull model, so that the edge of the restoration model is consistent with a skull defect edge; conducting a rollover operation on the restoration model and processing a solid mold; and pouring a mineralized collagen/polycaprolactone mixed suspension into the mold and conducting molding, so that the mineralized collagen-based skull defect restoration is obtained. According to the skull defect restoration and the preparation method thereof provided by the invention, perfect fit between the restoration edge and the skull defect edge is achieved, and moreover, new bone growth is guided, so that a post-operative skull curing effect is guaranteed.

The invention relates to a preparation method for the titanium mesh cranial prosthesis, which is characterized in that: the scanning picture of the CT thin layer is introduced into the two-dimensional coordinate region; a halfway line, a baseline, a line of reference and a plurality of construction lines of the brain are drew up; the reference sites of the cranium demanding to be repaired are determined in the intersection of each construction line and the fine cranium in the symmetrical region of the defect region; and the corresponding prosthesis element points are generated in the defect region of the cranium; the layer of the scanning picture corresponding with the element point, the number of the construction line and the vertical distance between the element point and the baseline are taken into recording; each sheet of the CT films of different layers is introduced into the coordinate region, so as to carry out the operation and form the data of all element points of cranial morphology in the defect region; and the titanium mesh is pressed with non-die multi-point former according with the data of the element points, so as to obtain the titanium mesh cranial prosthesis. The titanium mesh cranial prosthesis has the advantages that: the preparation of the titanium mesh cranial prosthesis can be finished; however the three-dimensional prototype of the head of the patients need not to be reconstructed; and the position of the element point can be properly selected according to the experience of the operator, so as to enable the shape of the repaired cranium to more accord with the cosmetic requirements.

The invention discloses an anatomy reconstruction skull patch filling a skull defect opening part. An edge shape of the patch is identical to an edge shape of the skull defect opening; a patch stereoscopic structure is identical to a skull defect stereoscopic structure; and the patch is made of degradable biological hard material. The invention further discloses an anatomy reconstruction skull patch quick manufacturing method. The patch manufacturing method can produce patches with high accuracy, great coupling property, great repairing exactness, firmness and safety as well as reliability; great patch structure and biocompatibility can be achieved; surgery cost can be reduced and time can be shortened; and post-surgery complications can be reduced.

The invention discloses a method for manufacturing an artificial skull restoration prosthesis through the 3D printing technology and other technologies. The method is used for manufacturing the artificial skull restoration prosthesis which is beautiful in appearance, is good in matching performance, causes few complications for skull defect patients. The method is characterized by artificially manufacturing the skull by comprehensively using the 3D printing technology and other technologies to achieve restoration and reconstruction of the skull of the patient, overcomes the defects of common skull restoration materials on the aspects of molding, strength, process, matching performance and the like, and obviously reduces side effects in clinical application.

The invention relates to a trephine having a limiting sleeve, wherein the trephine is used for a medical surgery purpose in skull defect and skull puncture surgeries. The trephine with the limiting sleeve comprises a motor, an internal trephine, and at least one trephine sleeve. The internal trephine is nested in the trephine sleeve by means of at least two bearings and is driven, by means of themotor, to rotate. The external trephine sleeve defines and adjusts the cutting depth of the internal trephine, while protecting a surgery operator and the tissue around a surgical site from being injured by a trephine rotating at a high speed; moreover, by drilling using the trephine having a limiting sleeve, a bone flap can be completely removed and retrieved from a trephined bone. The present invention realizes standardization and repetition of cranial defect and drilling surgery, and makes the surgery simple, easy to operate, safe and reliable, efficient, and is less traumatic. In a commonmedical researching laboratory condition, the trephine supplies a surgery technological insurance for a skull defect model and a clinical medical craniotomy and skull puncture of mice to large animals.

Paste containing at least one monomer for radical polymerization, at least one polymer that is soluble in said at least one monomer for radical polymerization, and at least one filling agent that is poorly soluble or insoluble in said at least one monomer for radical polymerization, wherein the filling agent is a particulate inorganic filling agent possessing a BET surface of at least 40 m²/g; kit comprising pastes A and B which, when mixed, form paste C, which pastes are useful for mechanical fixation of articular endoprostheses, for covering skull defects, for filling bone cavities, for femuroplasty, for vertebroplasty, for kyphoplasty, for the manufacture of spacers or for the production of carrier materials for local antibiotics therapy, as well as a form body produced from the pastes.

The invention belongs to the technical field of medical instruments and relates to a cerebral protection cap used after decompressive craniectomy of a craniocerebral operation, in particular to a pressure-controllable cerebral protection cap. The pressure-controllable cerebral protection cap consists of a cap body, a top adjuster, a left adjuster, a right adjuster, a movable air bag, a real-time pressure display instrument, a pressure control box, a fender bracket and an inflating pipe, wherein the movable air bag is arranged on the inner side of the cap body; the real-time pressure display instrument is fixedly arranged at the outer edge of the cap body through the fender bracket; and the pressure control box is connected with the pressure display instrument through the inflating pipe. The cerebral protection cap realizes real-time pressure display of the air bag, achieves free adjustment and control of pressure, is comfortable to wear and does not move after being inflated, is convenient to use and wear, and has high patient recognition degree, and application results show that the pressure-controllable cerebral protection cap can protect brain tissues with large-area skull defects and effectively promote rehabilitation of neural functions.

The invention provides a device for repairing skull base defects. An inner lock rack comprises a bundle of lock bars which can gather together; ends, at one side, of the lock bars are evenly and radially hinged to an inner lock nut; the inner lock nut is mounted on a connecting screw; an outer lock nut is fixed to the center of an outer lock rack; the outer lock nut is mounted on the connecting screw; the outer lock nut is fed along the connecting screw, so that an outer film is attached to the outer side of the skull and that pre-tightening force between the inner lock rack and the outer lock rack locks an inner film and the outer film to the inner and outer sides of the skull; the connecting screw is a hollow screw; the connecting screw is provided with a side hole located between the inner film and the outer film and communicated with an injection cavity. After silica gel injection, no leak occurs; filling is performed by external injection of the silica gel, the silica gel can fill the whole defective cavity to be repaired, with no lead angle left.

The invention discloses an intelligent processing device suitable for making defects of various shapes and of wall thicknesses. The processing device comprises a supporting frame, a lifting mechanism, a rotating mechanism and a controller. A two-dimensional motion mechanism and a cutting mechanism arranged on the two-dimensional motion mechanism are mounted in the supporting frame. The rotating mechanism is used for adjusting the cutting direction of a blade in the cutting mechanism. The two-dimensional motion mechanism is used for driving the cutting mechanism to carry out adjustment in the two-dimensional direction in the plane perpendicular to the lifting direction of the lifting mechanism. The controller is used for receiving three-dimensional model data of the defects to be processed and converting the three-dimensional model data into a running track of the two-dimensional motion mechanism and blade cutting direction data, and is used for controlling operation of the two-dimensional motion mechanism and the rotating mechanism. The intelligent processing device suitable for making the defects is simple in structure, low in manufacturing cost, convenient to operate, high in intelligent integration degree and capable of automatically making the skull defects different in wall thickness according to design requirements on the premise of not damaging tissue below bone walls, and the shapes of the defects are random.

The invention relates to a piston-shaped bone repairing support and application thereof. The piston-shaped bone repairing supporting consists of a support top and a support bottom, wherein thickness of the support top is between 0.5 and 1.5mm; the thickness of the support bottom is between 1 and 2mm; and the periphery of the support bottom is 1 to 3mm wider than the support top. The bone repairing support has the advantages that: when the piston-shaped bone repairing support is used for repairing defects of orbital wall and harnpan, the support material can be inserted into the position of the bone defect, and is matched excellently with a bone stump so as to facilitate the creeping and the replacement of a new bone towards the material; and meanwhile, the bone repairing support can be fixed excellently, avoids the movement of the support material, and solves the problem that materials on the positions of the orbital wall and the harnpan are difficult to fix.

The invention discloses a 3D printing scaffold material for icariin (ICA)-loaded PLGA microspheres, wherein the 3D printing scaffold material can be used for skull defect repairing. An ICA functionaldrug is adopted, endogenous osteoblasts are collected to a skull defect area to prompt osteoblast differentiation of the endogenous osteoblasts, meanwhile based on 3D printing design microspheres anda nano-hydroxyapatite micro-nano structure composite scaffold, an individualized bionic degradable polymer scaffold is prepared and can be absorbed and degraded in human bodies to avoid side effects of second operation and implantation materials, the effects of bone conduction and bone induction are achieved, bone tissue regeneration is prompted, and bone healing is prompted.

The invention discloses a craniocerebral three-dimensional forming restoration with a muscle base window. According to the craniocerebral three-dimensional forming restoration with the muscle base window, a medical three-dimensional forming material serves as a substrate, multiple mesh holes are formed in the substrate, the craniocerebral three-dimensional forming restoration with the muscle base window is provided with a smooth outline edge, a suitable individualized muscle base window three-dimensional structure is reserved for the skull defect zone muscular tissue of a patient at the edge, close to the base of skull, of an outline, the tissue combinations such as the muscles, the meninx and the brain which are attached to a skull defect zone are located at the inner side of the craniocerebral three-dimensional forming restoration with the muscle base window, the outline radian of the craniocerebral three-dimensional forming restoration with the muscle base window are formed with the consideration of the distribution condition of the tissue combinations such as the muscles, the meninx and the brain in the skull defect zone, so that it is guaranteed that the skull and the brain are repaired and protected together, and symmetry and beauty of the skull and the brain at the two sides are considered. Compared with the prior art, the craniocerebral three-dimensional forming restoration with the muscle base window has the following advantages that the internal environments such as brain blood supply and intracranial pressure maintenance are improved and recovery of the brain functions is facilitated.

The invention discloses micro RNA for accelerating tissue-engineered bone vascularization and application thereof and belongs to the technical field of gene engineering. The micro RNA is miR-26a, and the sequence is shown as SEQ. ID. NO. 1. The micro RNA for accelerating the tissue-engineered bone vascularization uses a mice skull defect regeneration model, preferential expression of the miR-26a is discovered in new bone, after transferring the miR-26a mimics and inhibitor into cell in vitro to realize the miR-26a expression increasing and decreasing, observing the regulation effect of the miR-26a for growth factors related to the angiogenesis in vitro in three osteogenesis related cell models, and using an in vivo and in situ bone defect and ectopic bone regeneration model to further verify the vascularization accelerating effect of the miR-26a in vivo.

The invention discloses a bFGF(Basic Fibroblast Growth Factor)-optimized ADM (acelluar dermal matrix) barrier membrane for promoting sclerous tissue regeneration as well as a preparation method and application of the ADM barrier membrane. A heparinized ADM membrane is soaked with a bFGF solution at 0-8 DEG C and then freeze-drying the membrane material at -60 DEG C to obtain a bFGF-loaded heparinized ADM membrane. According to the ADM barrier membrane as well as the preparation method and the application thereof, bFGF is loaded on the surface of a GTR (guided tissue regeneration) barrier membrane material, so that not only can a space retention function be developed, but also healing of skull defect of rats is accelerated through the actions of collecting mesenchymal stem cells and promoting proliferation. Therefore, according to the ADM barrier membrane as well as the preparation method and application thereof, an existing ADM membrane material is upgraded and the development of bone tissue engineering is promoted.

The invention relates to a novel scalp dilator special for a skull defect repair surgery. The novel scalp dilator is of a joint plier structure, and composed of a first rod part and a second rod part,and the first rod part and the second rod part are connected through movable shaft holes. The foot part of the first rod part is a right-angle bending plate, the right-angle bending plate is used forsearching and being attached to the skull fracture surface in the surgery, and can change the skull bone edge covered with proliferating granulation tissue into a visual marker. The foot part of thesecond rod part is of a milling shovel structure with a 90-degee rounded angle with a main body, and the foot part of the second rod part is used for extending into a scalp to raise the scalp. Duringthe surgery, a surgeon only needs to abut the foot part of the first rod part against the skull fracture surface, force is applied by fingers to close a handle, the foot part of the first rod part andthe foot part of the second rod part are separated through the lever effect, the scalp edge can be raised, and thus the cutting position can be quickly determined.

The invention relates to the technical field of medical appliances, and discloses a basis cranii repairing device for resection of pituitary adenoma via sphenoid sinus. The device comprises a first plug disc and a lumbar support formed on the first side of the first plug disc, wherein the first plug disc and the lumbar support have metal reticular structures; the second side surface of the first plug disc is coated with a first flexible blocking layer; the first flexible blocking layer is larger than the first plug disc, and the periphery of the first flexible blocking layer extends out of the edge of the first plug disc. The basis cranii repairing device can be used for effectively repairing the skull defect after repairing operation due to the first plug disc and the first flexible blocking layer, cerebrospinal fluid leakage is prevented, and infection rate is reduced.

The invention relates to a combined bone patch and a bone patch unit. The bone patch unit is a plate body, and comprises two opposite side surfaces and an outer ring wall surface, the outer ring wallsurface is connected between the two side surfaces, the plate body is provided with a plurality of binding posts and a plurality of binding grooves along the outer ring wall surface in a forming manner, and the shapes of the binding posts and the binding grooves correspond to each other; the combined bone patch is a bendable plate body, and comprises a plurality of interconnected bone patch units,and binding posts of one bone patch unit are inserted into binding grooves of the other bone patch unit among any two connected bone patch units; and the plurality of small bone patch units are combined and bent into the large combined bone patch which is consistent with the shape of a skull defect part, so that the material waste caused by cutting and processing expensive medical materials is avoided, and the manufacturing time can be saved.