38 results about "Skull defect" patented technology

Belongs to the technical field of biomedical engineering, and discloses a method, a device, equipment, a product and a storage medium for identifying skull defects by constructing a characteristic spectrum through a nuclear magnetic image to solve the problem that a defect area is mistakenly divided into skull areas in existing automatic skull segmentation. Converting the human brain nuclear magnetic image to an anatomical space based on the plurality of anatomical points, and implementing preliminary segmentation to obtain a primary segmentation region of the skull; calculating coordinates of voxel points in the primary segmentation region in an anatomical point coordinate system, establishing a matrix, calculating a plurality of nuclear magnetic gray statistical characteristics of the primary segmentation region, and drawing a characteristic spectrum; and performing multi-condition feature threshold judgment on the feature map to obtain a logic binary map, and extracting a region of which a connected domain is greater than a specified threshold as a skull defect region. According to the method provided by the invention, a plurality of gray features are utilized, the misrecognition of the skull in the prior art is effectively corrected, the method can be further used for judging the filling tissue of the skull defect area, and the skull defect recognition capability can be improved.

The invention discloses a preparation method and application of high-strength, high-inorganic-ratio and degradable organic-inorganic composite hydrogel, and belongs to the technical field of biomedical tissue engineering. The hydrogel is prepared from the following components in percentage by weight: 30 to 70 percent of calcium phosphate nano-cluster and 30 to 70 percent of sodium alginate. The organic-inorganic composite hydrogel is beneficial to proliferation and mineralization of bone cells, and more ideal bone guidance is realized. Experimental results prove that the material has good cytocompatibility, can quickly promote rat skull defect repair (8 mm limit bone injury repair time is shortened to 4 weeks), and has a more remarkable healing effect compared with a contrast autogenous bone graft material with an optimal clinical repair effect. The high-strength organic-inorganic composite hydrogel prepared by the invention is of a single-network structure, shows good mechanical properties, also has excellent degradability matched with tissues, and is beneficial to hard tissue repair.

The invention relates to the technical field of peek skull defect repair, in particular to a skull defect repair structure based on structural reconstruction of a peek skull repair material, which comprises a repair patch, a plurality of hourglass-shaped pore channels are formed in the surface of the repair patch, the diameter of the port of a horn-shaped concave groove is larger than that of the tail of the horn-shaped concave groove, the diameter of the port is 1.5 mm, the diameter of the tail of the horn-shaped concave groove is 0.05 mm, and the diameter of the hourglass-shaped pore channels is 1.5 mm. The hourglass-shaped hole channel is designed to be in an hourglass shape with two wide ends and a slender channel, the contact area between the two ends of the hole channel and healthy skull tissue is increased, growth, climbing and combination of granulation tissue are facilitated, meanwhile, attachment, adhesion and healing of soft tissue inside and outside a growth promoting layer repairing material are facilitated, the integration degree of the implant is further improved, and the survival rate of the implant is increased. And the outer surface of the PEEK is covered with the convex structures, so that the contact area between the PEEK material and tissues can be increased, the growth and combination of the tissues are facilitated, and individualized design conforming to aesthetic plastic surgery, thickening design for supplementing temporal muscle atrophy space and mutual embedding of the PEEK material and the skull are carried out.

The invention discloses an antibacterial bioactive glass composite material for skull defect repair and a preparation method thereof, and relates to the technical field of bioactive glass materials. The antibacterial bioactive glass composite material for skull defect repair is prepared from the following raw materials in parts by weight: 8 to 15 parts of collagen, 45 to 55 parts of bioactive glass, 20 to 30 parts of hydroxyapatite, 5 to 8 parts of a toughening agent, 1 to 2 parts of an antibacterial agent and 150 to 250 parts of deionized water. The antibacterial bioactive glass composite material for skull defect repair prepared by the invention has excellent bending strength and antibacterial property.

The invention relates to the technical field of image processing, in particular to a skull defect area intelligent segmentation method based on a medical image. The method comprises the following steps: acquiring a to-be-analyzed image and a template image of the brain; constructing a window by taking each pixel point as a center; obtaining a difference evaluation index of two windows with the same positions of the to-be-analyzed image and the template image; acquiring a skeleton line in the template image, acquiring pixel points corresponding to the pixel points in the template image on the skeleton line, and then obtaining included angles of the pixel points in the to-be-analyzed image; acquiring a neighborhood window of each window of the to-be-analyzed image, and judging whether each window is an initial abnormal window or not; judging whether each initial abnormal window is a suspected skull defect window or not; judging whether the suspected skull defect window is an abnormal window or not according to the gray level change condition of the pixel points in the suspected skull defect window; and segmenting the to-be-analyzed image according to the abnormal window to obtain a skull defect area. According to the method, the craniocerebral defect area can be effectively segmented.

The present invention belongs to the technical field of hydrogels. Specifically, it relates to a conductive hydrogel for skull defect repair, which is prepared by polymerizing methacrylated polysaccharide, ionic liquid monomer and two-dimensional titanium-based conductive material under the action of an initiator and a promoter. The mass fractions of methacrylated polysaccharide, ionic liquid monomer, two-dimensional titanium-based conductive material and initiator in the hydrogel are 1.0% - 5.0%, 1.0% - 10%, 0.1% - 5.0% and 0.1% - 2.0% respectively, and the volume fraction of the promoter is 0.05% - 1.0%. The methacrylated polysaccharide used in the conductive hydrogel of the present invention has good biocompatibility and biodegradability, and can be gradually degraded in vivo without producing toxic reactions; the two-dimensional titanium-based conductive material used has excellent electrical conductivity and high surface area, which improves the overall electrical conductivity of the hydrogel, and promotes the proliferation and differentiation of osteocytes and accelerates the regeneration and healing of bone tissue by providing weak electrical stimulation.

The invention discloses a polysaccharide-tea polyphenol-metal compound, which is formed by dispersing a metal-tea polyphenol nano ligand in polysaccharide gel formed by covalent crosslinking of atractylodes macrocephala polysaccharide and sodium alginate, and the metal-polyphenol nano ligand is a nano complex formed by coordination of tea polyphenol and metal ions. The invention also discloses a preparation method and application thereof. The rhizoma atractylodis macrocephalae polysaccharide-sodium alginate-tea polyphenol derivative-metal composite system disclosed by the invention not only can improve the stability and release behavior of tea polyphenol in vivo, but also can regulate and control an immunometabolism microenvironment in a bone repair process, induce inflammation resolution and promote angiogenesis and bone matrix deposition, so that the bone repair effect is improved. Multiple synergistic effects of inflammation resistance, oxidation resistance, vascularization promotion and osteogenesis induction are realized, so that repair and regeneration of skull defects are remarkably accelerated, and a new intelligent immunometabolism regulation strategy is provided for repair of complex bone defects.

The invention relates to an improved high-biological-activity osteogenic protein based on BMP9 (bone morphogenetic protein 9). The improved high-biological-activity osteogenic protein is formed by inserting a heparin binding site structure from a human fibroblast growth factor 2 into a protein structure of the BMP9. According to the invention, a recombinant adenovirus plasmid pAd-HB-hBMP9 is constructed, an SA (AGCGCC) is reserved at the C terminal of an HB structural domain so as to ensure the function of a wild type hBMP9 mature peptide, and before the HB structural domain is respectively inserted into the wild type hBMP9 mature peptide, the main functional structure of the wild type hBMP9 is not changed and influenced. The improved osteogenic protein with high biological activity has osteogenic activity higher than that of WT-hBMP9, can significantly induce bone marrow mesenchymal stem cell osteogenesis, and promotes healing of mouse skull defects. The method has a wide application prospect in the research fields of basis and clinical transformation of adenovirus-mediated osteogenic factor expression, gene therapy and the like.

The invention relates to a skull defect repairing structure based on a PEEK skull repairing material, and relates to the technical field of skull repairing, the skull defect repairing structure comprises a repairing sheet matched with a skull defect area, the repairing sheet is provided with a plurality of groove bodies and a hole body penetrating through the thickness direction of the groove bodies, and the hole body is internally provided with a blocking piece capable of switching states. The groove body is formed in the side, facing the scalp, of the repairing piece and used for guiding growth of scalp soft tissue and enhancing fusion of the repairing piece and the skull. The hole body is used for repairing climbing growth of scalp soft tissue after a structure installation operation, and after the scalp soft tissue grows and enters the hole body, the blocking piece is automatically switched to the blocking state from the communicating state under the gravity effect of the blocking piece, so that the scalp soft tissue is limited from penetrating to the brain side. The structure promotes integration of scalp soft tissue and the repairing piece, meanwhile, brain tissue is protected, the repairing effect is improved, and the installation safety of the repairing structure after an installation operation is improved.

The invention discloses a novel oligopeptide PSP for angiogenesis and vascularized bone regeneration. The tripeptide innovatively screened by the invention is short in amino acid sequence, small in molecular weight, high in bioavailability, low in synthesis cost and easy to transport, modify and recombine. The tripeptide provided by the invention can significantly promote vascularized bone regeneration and improve skull defect repair. Good application prospects are realized.

The utility model provides a skull plug which comprises a plug body and a plug cap, the plug body is cylindrical, the plug cap is connected with the plug body, the cross section of the plug cap along the center line of the plug cap is arc-shaped, and the diameter of the plug cap is larger than that of the plug body. When the skull plug is plugged into a skull defect position, the plug body is plugged into the defect position so as to be matched with other skull. On one hand, the plug cap covers the whole plug body and makes contact with bone tissue at other positions, the plug body can be prevented from entering the human body skull under the action of external force, and on the other hand, the shape of the plug cap is similar to that of the skull, so that the applicability of the skull plug is improved.

The invention relates to the technical field of medical data processing, in particular to a precise positioning system for incomplete skull time interference electrical stimulation treatment targets. The interference position analysis base model acquisition module is used for training an interference position analysis base model of the skull health user based on the graph neural network; the model selective activation module is used for selectively activating the interference position analysis base model based on a neuron node corresponding to the defect brain region position of the skull defect patient to obtain an interference position analysis selection model; the predicted interference position obtaining module is used for selecting a model through interference position analysis, processing the time interference stimulation parameters and preset individual parameters, and obtaining a predicted interference position; and the time interference stimulation parameter recommendation module is used for executing recommendation identification on the time interference stimulation parameters when the predicted interference position is consistent with the target interference position. The problems of inaccurate positioning, difficult electrode placement and the like caused by skull defects are solved.

The invention provides an adjustable fixing and positioning assembly for skull defect modeling, and belongs to the technical field of medical instruments. Comprising a molding supporting plate, four supporting protrusions are fixedly connected to the outer wall of the bottom of the molding supporting plate and distributed in a circumferential array, a first rotating groove is formed in the outer wall of the top of the molding supporting plate, a rotating supporting plate is rotationally connected to the inner wall of the first rotating groove, and a molding limiting block is fixedly connected to the outer wall of the top of the rotating supporting plate; the fixing assembly is used for fixing the head of the rat; the limiting assembly is used for limiting the skull electric drill. By arranging the fixing assembly, in the process of fixing the head of the rat, the operation process is simple, the time for fixing the head of the rat can be saved, and the experiment efficiency is improved; by arranging the limiting assembly, when the modeling angle of the skull electric drill is adjusted, the skull electric drill is forced to move in the direction away from a rat, and the situation that the skull electric drill scratches the rat and influences a modeling experiment is avoided.

The invention belongs to the technical field of hydrogel, and particularly relates to conductive hydrogel for skull defect repair, which is prepared by polymerizing methacrylated polysaccharide, an ionic liquid monomer and a two-dimensional titanium-based conductive material under the action of an initiator and an accelerant, the mass fraction of the methacrylated polysaccharide in the hydrogel is 1.0%-5.0%, the mass fraction of the ionic liquid monomer in the hydrogel is 1.0%-10%, the mass fraction of the two-dimensional titanium-based conductive material in the hydrogel is 0.1%-5.0%, the mass fraction of the initiator in the hydrogel is 0.1%-2.0%, and the volume fraction of the accelerant in the hydrogel is 0.05%-1.0%. The methacrylated polysaccharide adopted by the conductive hydrogel disclosed by the invention has good biocompatibility and biodegradability, and can be gradually degraded in vivo without generating toxic reaction; the adopted two-dimensional titanium-based conductive material has excellent conductivity and high surface area, the overall conductivity of the hydrogel is improved, and proliferation and differentiation of bone cells are promoted and regeneration and healing of bone tissues are accelerated by providing weak electrical stimulation.

The invention discloses a functional bone scaffold for bone defect repair as well as a preparation method and application thereof. The preparation method comprises the following steps: designing a three-dimensional structure of the scaffold according to a skull defect condition; preparing a PCL bracket by adopting a 3D printing technology; soaking the PCL stent in a mixed solution of icariin and dopamine, and enabling the mixed solution to be in contact with air; carrying out oscillation reaction on the reaction system for set time, and after the reaction is finished, taking out the stent, cleaning and drying to obtain the ICA-PPCL stent; and soaking the ICA-PPCL stent in a PBS (Phosphate Buffer Solution), soaking the ICA-PPCL stent in an exosome solution, and incubating for a set time to obtain the EXO-ICA-PPCL stent. A polyphenol structure of PDA and icariin can form a stable pi-pi accumulation effect, and the exosome is adsorbed through hydrophobic interaction, so that efficient loading and synchronous delivery of PDA and icariin are realized.

The present invention provides an adjustable fixed positioning assembly for skull defect modeling, which belongs to the technical field of medical instruments. It comprises a modeling support plate, four supporting protrusions are fixedly connected to the bottom outer wall of the modeling support plate, and are distributed in a circular array. A first rotating groove is provided on the top outer wall of the modeling support plate, a rotating support plate is rotatably connected to the inner wall of the first rotating groove, and a modeling limit block is fixedly connected to the top outer wall of the rotating support plate; the fixing assembly is used to fix the rat's head; the limiting assembly is used to limit the skull electric drill. By setting the fixing assembly, the present invention not only simplifies the operation process in the process of fixing the rat's head, but also saves the time of fixing the rat's head, thereby improving the efficiency of the experiment; by setting the limiting assembly, the present invention can force the skull electric drill to move away from the rat when adjusting the angle of the skull electric drill for modeling, thereby preventing the skull electric drill from scratching the rat and affecting the modeling experiment.

The head protection device for the bedridden skull defect patient comprises a protection cover which can be arranged on a sickbed, the lower end and the front end of the protection cover are open, the protection cover is used for covering the head of the patient, and the protection cover is fixed to the sickbed through a connecting mechanism. The protective cover is fixed on the sickbed through the connecting mechanism so as to prevent the protective cover from shifting, and foreign matters above the sickbed are prevented from falling off by the protective cover, so that the craniocerebral injury of a patient with skull defect is avoided; the head of the patient does not need to be bound, and the device is particularly suitable for bedridden skull defect patients.

1. The name of this design product: Melting Pen. 2. Purpose of the product of this design: medical device used for skull defect repair surgery. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: Stereoscopic drawing 1.

The invention discloses a shell-derived biphase calcium phosphate composite bone repair material as well as a preparation method and application thereof, and belongs to the field of biomedical materials. According to the preparation method, the shell-source calcium source and the calcium pyrophosphate are mixed, the biphase calcium phosphate (BCP) containing HAP and beta-TCP in different proportions is prepared through wet ball milling and solid-phase reaction, the reaction conditions are controlled in a simple mode, and the proportion of HAP to beta-TCP in the BCP is controllable. The biphase calcium phosphate prepared by the method is further compounded with sodium alginate, and the biphase calcium phosphate-sodium alginate composite scaffold is prepared by freeze drying and Cacrosslinking. The composite scaffold has a suitable porous structure, can exert in-vitro osteogenic induction activity and an in-vivo bone defect repair function, can significantly induce MC3T3-E1 cell alkaline phosphatase activity and induce calcium deposition, has osteogenic induction activity, can induce bone defect repair at an in-vivo rat skull defect part, and has a good application prospect. Excellent bone tissue engineering application prospects are shown.

1. The name of this design product: skull defect protection cap. 2. Purpose of the product with this design: The product with this design is used to protect the brain after decompression of the skull craniotomy. 3. The design key point of this appearance design product lies in the shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

This invention pertains to the field of biomedical engineering technology and discloses a method, apparatus, equipment, product, and storage medium for constructing feature maps from MRI images to identify skull defects. Addressing the problem of existing automatic skull segmentation methods misclassifying defect areas as skull regions, this invention converts human brain MRI images to anatomical space based on multiple anatomical points and performs preliminary segmentation to obtain primary segmented regions of the skull. It calculates the coordinates of voxel points in the primary segmented region within the anatomical point coordinate system, establishes a matrix, calculates multiple MRI grayscale statistical features of the primary segmented region, and draws a feature map. Multi-condition feature threshold judgment is applied to the feature map to obtain a logical binary map, and regions with connected components greater than a specified threshold are extracted as skull defect areas. The method provided in this application utilizes multiple grayscale features to effectively correct the misidentification of the skull in existing technologies and can further be used to determine the filling tissue in skull defect areas, thereby improving the ability to identify skull defects.

The fixing device comprises a fixing cover, the fixing cover is connected with a limiting ring, a pressurizing bag is arranged at the lower end of the fixing cover, the pressurizing bag is provided with an attaching part and an extruding part, and the attaching part protrudes outwards to form a protruding bag; the lower end of the protruding bag is of a circular truncated cone structure, and the upper end is of a long-strip-shaped columnar structure. The extrusion part of the extrusion bag is attached to the scalp at the skull defect position after the skull flap removal operation to pressurize and fix the skull defect position, when brain tissue swells, the extrusion part deforms to enable pressure in the extrusion bag to be increased, the protruding bag extends outwards, the pressure in the extrusion bag is increased to resist swelling of the brain tissue, and when the brain tissue does not swell any more, the extrusion part deforms to enable the pressure in the extrusion bag to be increased to resist swelling of the brain tissue. The pressure in the pressurizing bag is reduced, the protruding bag retracts, the pressurizing degree of the pressurizing bag is dynamically adjusted by observing the change of the protruding bag, the stability of brain tissue is improved, subdural effusion is reduced, the situation that the intracranial pressure is reduced due to leakage of cerebrospinal fluid caused by increase of surgical incision tension is avoided, and therefore craniocerebral collapse after craniocerebral flap removal is relieved.

This invention belongs to the field of biomaterials technology, specifically relating to a bioactive scaffold, its preparation method, and its applications. This invention incorporates functionalized mesoporous silica nanoparticles loaded with aminoguanidine into the skin secretions of the giant salamander and polycaprolactone electrospun fibers to construct a bioactive composite scaffold (SPMA). This scaffold enables the sustained release of AG and osteogenic factors, effectively inhibiting free radical generation, AGEs toxicity, and inflammatory responses. Furthermore, it significantly improves the survival rate, osteogenic differentiation, and mineralization capacity of bone marrow mesenchymal stem cells in a high-glucose microenvironment. In vivo experiments further demonstrate that in a streptozotocin-induced diabetic mouse model of skull defects, the SPMA scaffold can alleviate local inflammation, promote angiogenesis, and significantly accelerate new bone formation and defect repair.

The invention provides a soft-hard self-alternating highly-ordered organic-inorganic intercalated short fiber as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. According to the invention, sodium alginate hydrogel is bonded on the surfaces of a flexible inorganic SiO2 nanofiber membrane and HAP in a fixed-point manner through an intermolecular hydrogen bond bonding effect and a selective crystallization technology, so that a novel soft-hard self-alternating flexible organic-inorganic intercalation short fiber simulated bone plate (an ASH scaffold) is constructed. The ASH simulated bone plate bracket has excellent shape memory property, durability, effective slow release property and mechanical stress conduction property, so that distribution and release of BMSCs and HUVECs cell factors are adjusted. In addition, the ASH simulated bone plate scaffold shows good cell adhesiveness, vascularization ability and osteogenic induction potential. The AHS simulation bone plate with the alternate hardness and hardness and the multi-layer ordered structure can promote functional bone regeneration in rat full-thickness skull defects more quickly and better.

The invention discloses an electric drill bit for animal skull defect modeling, and belongs to the technical field of electric drill bits. Comprising a drill bit body, an annular interlayer is arranged on the lower portion in the drill bit body, a plurality of sets of fixing needles are arranged in the interlayer, the fixing needles are distributed in an annular array with the drill bit body as the axis, and a bottom annular plate is fixed to the position, around a drill bit of the drill bit body, of the bottom of the drill bit body. When the skull is modeled, firstly, the drill bit body is used for drilling a hole in the skull, when each downward part of the drill bit body needs to be further explored, the fixing needle is moved out of the opening through the push-out mechanism, the fixing needle can be inserted into the partially separated skull bone, then the drill bit body is lifted to judge the skull separation degree, and if the skull separation degree is not enough, the drill bit body is pushed out. By means of the mode, the skull can be separated carefully during drilling, and damage to meninx and brain parenchyma is avoided.

The invention belongs to the technical field of biological medicines, and discloses application of heteropeicosanol in preparation of a bone defect treatment medicine. Compared with the prior art, the method has the advantages that the apigenol can promote osteoblast proliferation, induce osteoblast mineralization and promote formation of new bones at bone defect parts, the effect of promoting osteoblast proliferation is optimal when the concentration of the apigenol is 1 * 10 <-7 >-1 * 10 <-6 > mol / L, and after 10 <-2 > mol / L of the apigenol is applied to treatment of rats with skull defect, the skull regeneration area can reach about 90%; and other treatment groups are obviously higher. As a bone defect treatment medicine, the apigenol has the advantage of high biological safety, after the apigenol is used for treating rats with skull defects, it is found that the apigenol does not cause cell hemolysis, brain tissues, livers and kidneys of rats in a medicine treatment group are not abnormal, and compared with a control group, the apigenol has no difference, so that the apigenol has a good clinical application prospect. The result shows that the iso-pinoselinol has good biological safety.

The present application relates to the technical field of medical data processing, and particularly relates to a precise positioning system for incomplete skull time interference electric stimulation treatment target. The interference position analysis base model acquisition module is used for training the interference position analysis base model of the skull health user based on the graph neural network; the model selective activation module is used for selectively activating the interference position analysis base model based on the neuron nodes corresponding to the defect brain region position of the skull defect patient, and obtaining the interference position analysis selected model; the predicted interference position acquisition module is used for processing the time interference stimulation parameters and the preset individual parameters through the interference position analysis selected model, and obtaining the predicted interference position; and the time interference stimulation parameter recommendation module is used for performing the recommendation identification on the time interference stimulation parameters when the predicted interference position is consistent with the target interference position. The present application solves the problems of inaccurate positioning and difficult electrode placement caused by skull defects.

The invention provides a 3D printing interlayer enhancement forming method for skull defect repair, and belongs to the technical field of 3D printing and medical implant manufacturing, and the method comprises the following steps: 1, based on medical imaging data of a skull defect area of a patient, constructing a personalized three-dimensional model matched with an anatomical structure of the skull defect area, and generating path data for 3D printing; 2, for the selected medical-grade polymer material, a 3D printing device is adopted to heat the polymer material in a differentiated temperature control mode by setting different temperature control areas; 3, a 3D printing device is adopted in the preset path direction, materials in different states are synchronously extruded and deposited through the double-spray-head structure, and finally an entity matched with the bone defect area structure is formed; and 4, carrying out surface cleaning and low-temperature drying treatment on the printed piece, and carrying out sterilization and sterile packaging according to medical use requirements. According to the invention, on the premise that the printing efficiency is not influenced, the tightness degree of interlayer bonding can be obviously improved.

The invention belongs to the technical field of biological medicine and oral medicine, and provides a 3D printing PEEK-based implant CP and 3DP as well as a preparation method and application thereof. A 3D printing polyether-ether-ketone (PEEK) implant is used as a carrier, a 3, 4-dihydroxy-L-phenylalanine mediated osteogenic peptide sequence PFS and an antibacterial peptide sequence GL13K are loaded, namely a chimeric peptide sequence, and the CP and 3DP are synthesized. An in-vitro cell experiment verifies the cell compatibility, the adhesion capability and the osteogenic differentiation capability of BMSCs, and an in-vitro bacteria experiment evaluates the capability of inhibiting adsorption, growth, reproduction and biological membrane formation of staphylococcus aureus and escherichia coli. And then implanting the PEEK-based implant in a rat skull defect model infected by staphylococcus aureus to prove the osteogenic differentiation promoting capability of the material. The PEEK-based implant expected to be obtained has good BMSCs adhesion, osteogenic differentiation and microbial infection inhibition capabilities, and is applied to oral maxillofacial bone implantation.