3D printing scaffold material for icariin (ICA)-loaded PLGA microspheres and application of 3D printing scaffold material

Abstract

The invention discloses a 3D printing scaffold material for icariin (ICA)-loaded PLGA microspheres, wherein the 3D printing scaffold material can be used for skull defect repairing. An ICA functionaldrug is adopted, endogenous osteoblasts are collected to a skull defect area to prompt osteoblast differentiation of the endogenous osteoblasts, meanwhile based on 3D printing design microspheres anda nano-hydroxyapatite micro-nano structure composite scaffold, an individualized bionic degradable polymer scaffold is prepared and can be absorbed and degraded in human bodies to avoid side effects of second operation and implantation materials, the effects of bone conduction and bone induction are achieved, bone tissue regeneration is prompted, and bone healing is prompted.

Description

technical field

[0001] The invention belongs to the field of composite materials, and in particular relates to a 3D printing support material of PLGA microspheres loaded with icariin and its application. Background technique

[0002] Bone is the main organ of the movement system of the human body and animals. It is mainly composed of bone tissue (including bone cells, collagen fibers and matrix, etc.), has a certain shape and structure, is covered with periosteum, contains bone marrow, and contains rich blood vessels and lymphatic vessels. And nerves, constantly undergoing metabolism and growth and development, have the ability to repair, regenerate and rebuild after trauma. As a bone scaffold, it endows the bone with good toughness and elasticity and can effectively regulate the crystallization and growth of inorganic minerals; the inorganic matter accounts for about 65% of the bone weight, and the main component is nano-hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 , nHAP) gr...

Images