16 results about "Entire cell" patented technology

The invention provides a method, device and system for evaluating the effect of intervening small molecules by tumors and a storage medium, and relates to the technical field of bioinformatics, the method comprises the following steps: obtaining a first transcriptome representation of a tumor cell population before target small molecule intervention and a second transcriptome representation of a normal tissue cell population corresponding to the tumors; inputting the first transcriptome representation and the condition vector into a prediction model to obtain a third transcriptome representation; calculating a first distance and a second distance; an intervention effect is evaluated based on a comparison of the first distance and the second distance. According to the method, the influence of the drug on the transcriptome of the whole cell population is efficiently predicted, and the distance between the transcriptome and the health state is quantitatively compared, so that a set of brand new standard for improving the evaluation target from the traditional'killing cell 'to'reversing disease state' is established, and an objective decision basis is provided for developing more accurate drugs.

The present invention relates to the technical field of power batteries, and provides a battery cell cover plate, a cover plate assembly and a battery cell, the battery cell cover plate comprises: a cover plate body having two plate surfaces arranged back to back in the thickness direction of the cover plate body, one of the plate surfaces forming a support surface; the pole hole penetrates through the cover plate body; the supporting convex hull is arranged on the supporting surface in a protruding mode, and the height H1 of the supporting convex hull protruding out of the supporting surface meets the condition that H1 is larger than or equal to (H + 1.0 mm) and smaller than or equal to (H + 2.0 mm); wherein H is the height of the pole protruding out of the supporting surface. When the upper surface of the whole battery pack is impacted by external force, the impact force can be borne by the supporting convex hulls, direct stress of the pole columns is avoided, the short-circuit risk of the battery cell is reduced, the impact external force borne by the supporting convex hulls can be directly dispersed to the cover plate body and even the whole shell of the battery cell, the supporting performance of the shell of the battery cell is exerted, and the mechanical strength of the whole battery pack is improved; and long-term stable operation of the battery cell is ensured. And the supporting convex hulls can also improve the heat dissipation effect of the battery cell and improve the quick charging performance of the battery cell.

This invention relates to the field of cylindrical batteries, specifically a cylindrical battery structure with positive and negative electrodes on the same side. It addresses the technical problems of existing cylindrical battery structures that mostly employ structures where positive and negative electrodes are led out from two opposite end faces. This structure forces current to flow through the casing, resulting in increased internal resistance and severe heat generation in the entire cell. Furthermore, in cell structures with tabs on opposite sides, the current collectors for both positive and negative electrodes occupy battery space, reducing the area for chemical coating on the electrodes and thus lowering the overall capacity of the cell. The invention includes a casing, a lower insulating sheet, a cell, a positive current collector, a negative current collector, an upper insulating sheet, and a top cover. The casing is a cylinder open at one end. The cell has a positive electrode tab area, a negative electrode tab area, and a tabless area, all located on the same side of the cell. The upper insulating sheet has an electrolyte immersion port, a central positioning post, and an opening for the current collector.

The present application relates to the technical field of solar photovoltaic module manufacturing, and provides a solar photovoltaic module. The solar photovoltaic module comprises a plurality of cell strings; each cell string comprises a plurality of cell pieces of which edges are sequentially stacked and which are electrically connected; the cell pieces are obtained by cutting an entire cell; and in an extension direction of the cell string, for two adjacent cell pieces, a non-cutting edge of a preceding cell piece is located above a cutting edge of a subsequent cell piece, and the non-cutting edge of the preceding cell piece is located at a light receiving side of the photovoltaic module. The photovoltaic module having a specific structure can effectively improve the power generation efficiency of the photovoltaic module, and also has advantages such as a short research and development period and low research and development costs.

The invention discloses a layout quality verification method for an integrated circuit standard cell library, and aims to solve the problems that design errors are exposed during later integration and the design efficiency is reduced due to the fact that only a single standard cell is checked and an actual application scene cannot be simulated in a traditional method. It is ensured that errors are not reported when unit data are read in the layout and wiring stage; through modular random splicing, a layout and wiring environment can be simulated to the greatest extent, and a complete module is generated. A physical unit is inserted, invalid error reporting is avoided, DRC checking of the module is carried out, and layout and wiring are ensured; the units are spliced in a pairwise surrounding manner, so that the ergodicity of the spliced units and the test coverage rate of the spliced surfaces are ensured; through winding property inspection, it is ensured that accidental DRC is not generated due to connection punching when the layout wiring tool is connected to a standard unit.

The invention relates to a method for dynamically encapsulating microbial cells by using a hydrogen bond organic framework material, and belongs to the technical field of cell encapsulation. The method comprises the following steps: preparing nano HOF, dispersing cells in a culture medium, adding a nano HOF aqueous dispersion, culturing, and dynamically packaging proliferative cells by the HOF. According to the invention, a hydrogen bond organic framework material monomer containing carboxyl is selected to encapsulate cells, self-assembly of organic molecule units on the surfaces of the cells is realized through a dynamic hydrogen bond network, and highly reversible hydrogen bonds interact to construct an intelligent encapsulation shell with a controllable disassembly / assembly function; and continuous packaging protection in the whole cell proliferation process can be realized.

This invention relates to the field of tumor vaccines, specifically to an anti-tumor vaccine, its preparation method, and its application. The invention prepares an anti-tumor vaccine, BCG-CW@LNT, by mixing cell walls extracted from BCG vaccine as an immune adjuvant with LNT cells obtained from tumor cells through rapid freeze-thaw cycles in liquid nitrogen. This vaccine utilizes these "therapeutic dead cells" to induce a broad antigen response throughout the entire cell, mimicking the natural presentation of antigens in the tumor microenvironment, thereby enhancing anti-cancer immunity. In bladder cancer and lung cancer models, BCG-CW@LNT demonstrated good anti-tumor therapeutic effects. Furthermore, due to the presence of memory T cells, it exhibits a long-term memory effect, providing long-term anti-tumor and preventative effects, effectively preventing tumor recurrence and offering a novel option for tumor treatment.

The present invention relates to a bioreactor for cell culture. According to an embodiment of the present invention, vibration is provided to a cell culture solution (solution) to facilitate cell separation, and, since the vibration is transmitted to the entire cell culture solution without dead zones, cell separation efficiency is excellent.

To provide a cell suction system capable of accurately moving a needle tip of a needle part of a chip to a position of a cell to be sucked after connecting a chip connection shaft of a suction unit to a chip base part of the chip held in a chip container.SOLUTION: A suction unit having a chip connection shaft connected to a chip base of a chip held in a chip container, the suction unit causing a needle portion of the chip to suck and hold a cell component or an entire cell from a cell through the needle tip in a state in which the chip is connected to the chip connection shaft, and a chip container holder configured to allow relative movement of the chip and the chip container with respect to the chip connection shaft to eliminate misalignment when the chip connection shaft is connected to the chip base of the chip held in the chip container; A tip container holding section that holds the tip container.SELECTED DRAWING: Figure 1

The application discloses an AIE fluorescent dye, a structural formula of which is shown in the following formula (I), wherein R1 and R2 are independently selected from alkyl alcohol with carbon number of 1-6; and X is selected from water-soluble anions. The fluorescent dye disclosed by the application has AIE characteristics, can realize rapid staining of living cells, and the staining depth can be deep to the nucleolus of the cell nucleus, so that the morphology of the whole cell tissue is clear and visible; is expected to be applied in the field of living cell fluorescence imaging, and further used for preparing a fluorescent kit for rapid diagnosis of cancer cells; the fluorescent probe has good water solubility, small cytotoxicity and good biocompatibility; the fluorescent color is orange red, the Stokes shift is large, and the anti-self-fluorescence interference ability is strong.

The utility model discloses a cell resuscitation instrument capable of realizing accurate temperature control, which comprises a shell, a plurality of heating modules for cell resuscitation are arranged in the upper space of the shell at intervals, and each heating module comprises a heating groove for placing a cryopreservation tube. The temperature detection module is used for detecting temperature; the main control unit is used for triggering the heating module to heat the cryopreservation tube; the main control unit is electrically connected with the temperature detection module to realize timing control and temperature control of cell resuscitation; and a waste heat isolation device for blocking a heat source of the heated cryopreservation pipe is arranged in the heating tank. According to the structure, temperature control protection is achieved through the temperature detection module and the main control unit, accurate temperature control is achieved under the cooperation of the waste heat isolation device, multiple samples can be treated at the same time through the multiple heating modules arranged at intervals, the high-throughput experiment requirement is met, operation is easy in the whole cell resuscitation process, and sample pollution is avoided.

A cell suction system includes a suction unit and a chip container holder. The suction unit includes a chip connection shaft to be connected to a chip base of a chip held in a chip container, and causes the chip to suck and hold a cell component of a cell or an entire cell from a needle tip of a needle portion, in a state in which the chip is connected to the chip connection shaft. The chip container holder holds the chip container so as to allow movement of the chip and the chip container relative to the chip connection shaft, to eliminate axial misalignment when the chip connection shaft is connected to the chip base of the chip held in the chip container.

The invention discloses a multifunctional organoid reagent circulation and drug delivery system and a method thereof, and aims to solve the problem that a circulation system is polluted due to the fact that an existing cell culture device is single in function and cannot realize independent and accurate drug delivery. The system comprises at least one circulating drug delivery module and a circulating and drug delivery chip and is matched with a culture chip for use, drugs can be accurately injected into a circulating loop through an independent drug delivery pool, a main culture system is prevented from being polluted, long-term circulating perfusion and controllable drug delivery culture of a single organ are supported, and by configuring a plurality of independent circulating drug delivery modules, the drug delivery efficiency is improved. Parallel experiments of a plurality of organoids are realized, and the experiment efficiency is remarkably improved; the whole cell culture process is in a sealed state, and the in-vivo dynamic circulation process can be accurately simulated in the cell culture process, so that the problems of cross contamination and the like in the conventional culture experiment process are avoided; all the circulating pools and the dosing pools are integrated in the circulating and dosing chip, so that centralized management is realized, and the operation process is simplified.

The application discloses a method for researching a whole surface mechanical atlas of a single adherent biological cell under physiological conditions, and belongs to the technical field of microscopic imaging testing. The method is based on the principle of nanoindentation technology under physiological conditions, and uses an optical microscope to perform coarse positioning on a sample to be tested, and selects the sample and sets a grid standard according to requirements. Each square of the grid is used as a basic unit, and mechanical property testing is performed on the position of each center point, and finally the testing results are output in the form of a grid pixel, so that the whole surface mechanical atlas of the adherent cell is obtained. The purpose of the application is to obtain the mechanical information of the whole cell surface under physiological conditions by using microscopic manipulation technology, and to output the analysis results in the mode of a pixel map, so that people can more intuitively understand the adhesion force difference of the whole cell surface, and a method for testing results is provided, which is more intuitive, simple and comprehensive for the in-depth research on the physical properties of cells.

A non-invasive method for measuring the motion characteristics of myocardial tissue includes: transmitting a plurality of generated synchronous quadrature, different frequency, phase controllable adjustable periodic alternating current to a living body (20) to generate a plurality of different frequency periodic alternating voltage signals; receiving the alternating voltage signals modulated by the changes of the cardiac tissue (25) in the living body (20) to obtain the frequency response of the living body (20); calculating the resistance and capacitance of the cardiac tissue (25) according to the frequency response; and estimating the motion characteristics of the myocardial tissue according to the resistance and capacitance. By introducing the longitudinal average length of myocardial cells and calculating the longitudinal average length change of the myocardial cells according to the capacitance, a description method of the longitudinal elasticity of the whole heart is given. A continuous, high sampling rate, non-invasive method is provided to measure the motion of the myocardial tissue at the whole cell level, so that more subtle abnormal changes of the myocardial cells can be detected.

Provided in the present application are a battery pack and an electric apparatus. The battery pack comprises: a housing defining an accommodating cavity; and an energy storage device arranged in the accommodating cavity, wherein the energy storage device comprises: a packaging film, a cell module and an encapsulation layer; the cell module comprises a plurality of solid-state cells arranged side by side in a first direction and electrically connected to each other, electrical connection parts of the plurality of solid-state cells being covered by means of the encapsulation layer; the packaging film wraps the cell module; and the cell module further has a first connection terminal and a second connection terminal which extend from the packaging film. In the battery pack of the present application, the electrical connection parts of the plurality of solid-state cells of the cell module are fixed by means of the encapsulation layer, then the entire cell module is packaged by the packaging film, such that the formed battery pack has only one packaging film. More solid-state cells can be accommodated in the battery pack, thereby improving the utilization rate of the internal space of the battery pack, and thus improving the energy density of the battery pack.