36 results about "Entire cell" patented technology

The invention provides a method, device and system for evaluating the effect of intervening small molecules by tumors and a storage medium, and relates to the technical field of bioinformatics, the method comprises the following steps: obtaining a first transcriptome representation of a tumor cell population before target small molecule intervention and a second transcriptome representation of a normal tissue cell population corresponding to the tumors; inputting the first transcriptome representation and the condition vector into a prediction model to obtain a third transcriptome representation; calculating a first distance and a second distance; an intervention effect is evaluated based on a comparison of the first distance and the second distance. According to the method, the influence of the drug on the transcriptome of the whole cell population is efficiently predicted, and the distance between the transcriptome and the health state is quantitatively compared, so that a set of brand new standard for improving the evaluation target from the traditional'killing cell 'to'reversing disease state' is established, and an objective decision basis is provided for developing more accurate drugs.

The present invention relates to the technical field of power batteries, and provides a battery cell cover plate, a cover plate assembly and a battery cell, the battery cell cover plate comprises: a cover plate body having two plate surfaces arranged back to back in the thickness direction of the cover plate body, one of the plate surfaces forming a support surface; the pole hole penetrates through the cover plate body; the supporting convex hull is arranged on the supporting surface in a protruding mode, and the height H1 of the supporting convex hull protruding out of the supporting surface meets the condition that H1 is larger than or equal to (H + 1.0 mm) and smaller than or equal to (H + 2.0 mm); wherein H is the height of the pole protruding out of the supporting surface. When the upper surface of the whole battery pack is impacted by external force, the impact force can be borne by the supporting convex hulls, direct stress of the pole columns is avoided, the short-circuit risk of the battery cell is reduced, the impact external force borne by the supporting convex hulls can be directly dispersed to the cover plate body and even the whole shell of the battery cell, the supporting performance of the shell of the battery cell is exerted, and the mechanical strength of the whole battery pack is improved; and long-term stable operation of the battery cell is ensured. And the supporting convex hulls can also improve the heat dissipation effect of the battery cell and improve the quick charging performance of the battery cell.

The invention discloses cell enriching and dyeing integrated equipment which comprises a base; the enrichment assembly is arranged on the base and is used for enriching target cells; the dyeing assembly is arranged on the base and is used for dyeing target cells; the liquid adding assembly comprises a first guide rail arranged on the base, a first liquid adding pipe and a second liquid adding pipe, the first liquid adding pipe and the second liquid adding pipe are in sliding fit with the first guide rail, the first liquid adding pipe is used for adding a first reagent to the enrichment assembly, and the second liquid adding pipe is used for adding a second reagent to the dyeing assembly. The enrichment assembly and the dyeing assembly are integrated on the same base, the liquid adding assembly with the first liquid adding pipe and the second liquid adding pipe which can slide along the guide rail is arranged, the guide rail design of the liquid adding assembly ensures the accuracy and repeatability of liquid adding, mechanical operation of reagent adding is achieved, and the reagent adding efficiency is improved. The time and steps for manually taking and placing the reagent are obviously reduced, so that the efficiency of the whole cell enrichment, dyeing and subsequent identification process is effectively improved.

The utility model relates to the technical field of lithium ion batteries, and discloses a square steel shell structure and a battery. The square steel shell structure comprises a square shell provided with a battery cell mounting groove and a cover plate used for blocking a notch of the battery cell mounting groove; a plurality of reinforcing columns are fixedly arranged at the groove bottom of the battery cell mounting groove; and one end, far away from the groove bottom of the battery cell mounting groove, of the reinforcing column is fixedly connected with the cover plate. According to the square steel shell battery cell, the fixing columns are additionally arranged in the square shell, and the square shell and the cover plate are fixed, so that the whole battery cell is subjected to segmented reinforcement, the deformation resistance of each part of the square steel shell structure is enhanced, the problem that the square steel shell structure is easy to deform is effectively solved, and the service life of the square steel shell battery cell is prolonged.

This invention relates to the field of cylindrical batteries, specifically a cylindrical battery structure with positive and negative electrodes on the same side. It addresses the technical problems of existing cylindrical battery structures that mostly employ structures where positive and negative electrodes are led out from two opposite end faces. This structure forces current to flow through the casing, resulting in increased internal resistance and severe heat generation in the entire cell. Furthermore, in cell structures with tabs on opposite sides, the current collectors for both positive and negative electrodes occupy battery space, reducing the area for chemical coating on the electrodes and thus lowering the overall capacity of the cell. The invention includes a casing, a lower insulating sheet, a cell, a positive current collector, a negative current collector, an upper insulating sheet, and a top cover. The casing is a cylinder open at one end. The cell has a positive electrode tab area, a negative electrode tab area, and a tabless area, all located on the same side of the cell. The upper insulating sheet has an electrolyte immersion port, a central positioning post, and an opening for the current collector.

The present application relates to the technical field of solar photovoltaic module manufacturing, and provides a solar photovoltaic module. The solar photovoltaic module comprises a plurality of cell strings; each cell string comprises a plurality of cell pieces of which edges are sequentially stacked and which are electrically connected; the cell pieces are obtained by cutting an entire cell; and in an extension direction of the cell string, for two adjacent cell pieces, a non-cutting edge of a preceding cell piece is located above a cutting edge of a subsequent cell piece, and the non-cutting edge of the preceding cell piece is located at a light receiving side of the photovoltaic module. The photovoltaic module having a specific structure can effectively improve the power generation efficiency of the photovoltaic module, and also has advantages such as a short research and development period and low research and development costs.

The present invention relates to the field of cell sample storage technology, and in particular to a closed flow cell sample processing device. The device comprises a sealing ring membrane that separates the storage cavity into a first chamber and a second chamber that are not connected to each other, and the sealing ring membrane comprises a sealing body, a first opening blind seam, a second opening blind seam and a guide slot, wherein the second opening blind seam corresponds to the position of the first opening blind seam; the guide slot is used to quickly break the sealing ring membrane and guide the cell sample to be extruded vertically in a jet-like shape after being pressurized. The present invention can break the sealing ring membrane by pressure in a completely closed state, and extrudes the cell sample in a jet-like shape from the discharge head of the storage device in a jet-like shape after being pressurized, and vertically injects it into the sample tube to be mixed. During the entire cell sample adding operation, the cell sample does not come into contact with the external environment, thereby ensuring that the cell sample is not contaminated by the external environment to a great extent, avoiding external contamination, and improving the sterility of the sample processing.

The invention discloses a layout quality verification method for an integrated circuit standard cell library, and aims to solve the problems that design errors are exposed during later integration and the design efficiency is reduced due to the fact that only a single standard cell is checked and an actual application scene cannot be simulated in a traditional method. It is ensured that errors are not reported when unit data are read in the layout and wiring stage; through modular random splicing, a layout and wiring environment can be simulated to the greatest extent, and a complete module is generated. A physical unit is inserted, invalid error reporting is avoided, DRC checking of the module is carried out, and layout and wiring are ensured; the units are spliced in a pairwise surrounding manner, so that the ergodicity of the spliced units and the test coverage rate of the spliced surfaces are ensured; through winding property inspection, it is ensured that accidental DRC is not generated due to connection punching when the layout wiring tool is connected to a standard unit.

The utility model discloses a mobile phone shell with a replaceable back panel, belongs to the technical field of mobile phone shells, and mainly solves the problems that in the prior art, a mobile phone shell is of an integrated shell structure, a back plate behind the shell is difficult to disassemble and replace, the whole mobile phone shell needs to be replaced once decoration needs to be replaced due to the single pattern of the mobile phone shell, and the cost is high. The mobile phone shell comprises a mobile phone shell body, a combination groove is formed in the mobile phone shell body in a penetrating mode, a positioning skirt edge is fixedly connected to the interior of the combination groove, an installation back plate is embedded into the combination groove, and a first magnet block is embedded into the front face of the positioning skirt edge; second magnet blocks corresponding to the first magnet blocks are embedded in the back face of the mounting back plate, clamping grooves are formed in the two sides of the mounting back plate, two symmetrical mounting bases are fixedly connected into the combined groove, guide sliding grooves are formed in the mounting bases, movable blocks are slidably mounted in the guide sliding grooves, and limiting clamping blocks are fixedly connected to one ends of the movable blocks.

The invention relates to a GelMA hydrogel micro-fluidic chip and application of the GelMA hydrogel micro-fluidic chip in cell culture and drug testing. The micro-fluidic chip is made of GelMA hydrogel and specifically comprises a cell culture chamber, and micro-columns arranged in an array are arranged in the cell culture chamber; the drug delivery channel surrounds the periphery of the cell culture chamber; and the gel bionic barrier layer is arranged between the cell culture chamber and the drug delivery channel and is used for inducing the drug in the drug delivery channel to diffuse into the cell culture chamber. The application of the GelMA hydrogel micro-fluidic chip in cell culture and drug testing comprises the following steps: adding a cell solution from a cell solution inlet until the whole cell culture chamber is filled with the cell solution; a to-be-tested medicine solution is added into the medicine conveying channel, and the action effect of the tested medicine on the cells is simulated. Compared with the prior art, the micro-fluidic chip disclosed by the invention has the advantages that the drug can be diffused from the periphery to the internal cell culture chamber, and the micro-fluidic chip can be applied to cell culture and high-throughput drug test.

The invention discloses a modular flow cytometer and a use method thereof, and belongs to the technical field of flow cytometers, a cell sorting and collecting module is detached, then a rotating handle is rotated to enable a connecting shaft to drive a worm to rotate, a plurality of push plates drive a plurality of clamping strips to synchronously move and separate from clamping grooves in a bottom groove, and after a shell of the flow cytometer is lifted upwards, the flow cytometer is separated from the bottom groove. Fastening screws on the two sides of the isolation frame are unscrewed so that the isolation frame can be separated from the two sides of the movable supporting module, the isolation frame is lifted so that insertion holes in the isolation frame can be separated from a plurality of limiting columns in the movable supporting module, and the supporting and protecting module and the isolation frame can be detached from the movable supporting module. According to the cytometer disclosed by the utility model, the convenience of transferring and carrying the cytometer is improved, independent carrying or combined carrying is more labor-saving, the consumption of manpower and material resources can be effectively reduced, modules with problems can be pointedly overhauled or replaced, the whole cytometer does not need to be disassembled, and the maintenance difficulty is reduced.

A modular space antenna cell skeleton structure with equal rib length and equal gap, a generation method, a system, a medium and an apparatus. In the method, an upper initial skeleton structure of a central cell is generated, where the lines connecting the six vertices of a regular hexagon and the geometric center point form six ribs, which constitute the upper initial skeleton structure of the central cell; skeleton structures of other cells are generated, where the skeleton structures of other cells are generated in units of ribs, and the newly generated ribs are connected to the ribs, so the vertex at one end of the newly generated rib is known, and the two vertices of the newly generated rib serve as key points. The set of key points of all ribs in a single cell serves as the key point of the cell; all ribs and key points are gradually generated along a path from the center to the edge, and all key points are updated to generate gaps between cells; the key points are extended along the direction from the center of the sphere to itself by the distance of a back frame to obtain new key points; and the key points are connected in sequence to obtain the skeleton structure of the entire cell.

The invention relates to a method for dynamically encapsulating microbial cells by using a hydrogen bond organic framework material, and belongs to the technical field of cell encapsulation. The method comprises the following steps: preparing nano HOF, dispersing cells in a culture medium, adding a nano HOF aqueous dispersion, culturing, and dynamically packaging proliferative cells by the HOF. According to the invention, a hydrogen bond organic framework material monomer containing carboxyl is selected to encapsulate cells, self-assembly of organic molecule units on the surfaces of the cells is realized through a dynamic hydrogen bond network, and highly reversible hydrogen bonds interact to construct an intelligent encapsulation shell with a controllable disassembly / assembly function; and continuous packaging protection in the whole cell proliferation process can be realized.

The invention discloses an oral tumor cell line and a construction method thereof, and relates to the technical field of oral tumors, and the construction method specifically comprises the following steps: after subculture is carried out in vitro for 2-6 months, vigorously proliferated clones appear in a culture, and cells obtain non-death, non-death, non-death and non-death cells; therefore, the whole cell line can stably survive in vitro and can be stably passed to the 17th generation, more importantly, a cell experiment platform can be provided for further researching a molecular mechanism, a pathological development process, a drug intervention experiment and the like of the diffuse malignant peritoneal mesothelioma, and the whole survival time of the cell line is prolonged; the immortalized oral tumor cell line can be simply and quickly established by the method disclosed by the invention, and compared with a traditional tumor cell establishment method, the immortalized oral tumor cell line is simple, time-saving and labor-saving; the established new oral tumor cell strain has a wide application prospect in the research of oral tumor pathogenesis, the research of immune system and the screening of oral tumor drugs.

This invention relates to the field of tumor vaccines, specifically to an anti-tumor vaccine, its preparation method, and its application. The invention prepares an anti-tumor vaccine, BCG-CW@LNT, by mixing cell walls extracted from BCG vaccine as an immune adjuvant with LNT cells obtained from tumor cells through rapid freeze-thaw cycles in liquid nitrogen. This vaccine utilizes these "therapeutic dead cells" to induce a broad antigen response throughout the entire cell, mimicking the natural presentation of antigens in the tumor microenvironment, thereby enhancing anti-cancer immunity. In bladder cancer and lung cancer models, BCG-CW@LNT demonstrated good anti-tumor therapeutic effects. Furthermore, due to the presence of memory T cells, it exhibits a long-term memory effect, providing long-term anti-tumor and preventative effects, effectively preventing tumor recurrence and offering a novel option for tumor treatment.

The present invention relates to a bioreactor for cell culture. According to an embodiment of the present invention, vibration is provided to a cell culture solution (solution) to facilitate cell separation, and, since the vibration is transmitted to the entire cell culture solution without dead zones, cell separation efficiency is excellent.

To provide a cell suction system capable of accurately moving a needle tip of a needle part of a chip to a position of a cell to be sucked after connecting a chip connection shaft of a suction unit to a chip base part of the chip held in a chip container.SOLUTION: A suction unit having a chip connection shaft connected to a chip base of a chip held in a chip container, the suction unit causing a needle portion of the chip to suck and hold a cell component or an entire cell from a cell through the needle tip in a state in which the chip is connected to the chip connection shaft, and a chip container holder configured to allow relative movement of the chip and the chip container with respect to the chip connection shaft to eliminate misalignment when the chip connection shaft is connected to the chip base of the chip held in the chip container; A tip container holding section that holds the tip container.SELECTED DRAWING: Figure 1

The invention relates to a half-piece cutting and repairing method for a solar cell piece, a half-piece cell piece, a solar cell module and a preparation method of the solar cell module. According to the method, after the whole piece is cut through laser, the cutting face is sequentially subjected to alkali polishing treatment, laser energy oxidation and deposition passivation dual repair; wherein the surface of the alkali-polished plane is subjected to hydroxyl (-OH) treatment, so that the adsorption capacity of oxygen molecules can be improved, then laser energy acts on the oxygen molecules adsorbed on the cutting surface, silicon oxide is formed through oxidation, a silicon nitride layer is formed through deposition and passivation, and the cut solar cell half-piece section is obtained. The defects of microcracks and lattice damage of the cell cutting surface caused by laser cutting are repaired, and the power of the solar cell half-piece assembly is further improved.

The invention relates to a bypass diode configuration method and system for a photovoltaic module, and the method comprises the steps: dividing the photovoltaic module into a plurality of battery strings, each battery string comprises n battery pieces which are connected in series, and each battery string is provided with a diode; when only one battery piece in one battery string fails, the diode provides a bypass for the failed battery piece; when two or more battery pieces in one battery string break down, the diode provides a bypass for the battery string. According to the invention, the bypass can be dynamically provided for the fault cell, the configuration of the diode is reduced, and the power generation efficiency of the photovoltaic module is improved.

The application discloses an AIE fluorescent dye, a structural formula of which is shown in the following formula (I), wherein R1 and R2 are independently selected from alkyl alcohol with carbon number of 1-6; and X is selected from water-soluble anions. The fluorescent dye disclosed by the application has AIE characteristics, can realize rapid staining of living cells, and the staining depth can be deep to the nucleolus of the cell nucleus, so that the morphology of the whole cell tissue is clear and visible; is expected to be applied in the field of living cell fluorescence imaging, and further used for preparing a fluorescent kit for rapid diagnosis of cancer cells; the fluorescent probe has good water solubility, small cytotoxicity and good biocompatibility; the fluorescent color is orange red, the Stokes shift is large, and the anti-self-fluorescence interference ability is strong.

The present invention belongs to the technical field of secondary batteries, and in particular relates to a method for replenishing negative electrode lithium, comprising the following steps: step S1, performing a charge and discharge test on a button cell containing a lithium replenisher to obtain a first spectrum; step S2, determining an addition amount of the lithium replenisher; step S3, performing a charge and discharge test on the button cell containing the lithium replenisher in the determined amount and a positive electrode active material to obtain capacity utilization in different voltage segments; step S4, comparing the capacity utilization in step S3 with the first spectrum in step S1 to obtain a second spectrum; step S5, converting and calculating the amount of active lithium required for replenishment in each cycle based on the capacity loss during each cycle; step S6, calculating the discharge cutoff voltage of the entire cell in each cycle based on the electrode potentials of the positive and negative electrode active materials; and step S7, controlling the discharge cutoff voltage of the cell according to the needs of the charge and discharge cycle to slowly release the active lithium in the negative electrode.

The invention relates to the technical field of cell sample storage, in particular to a closed flow type cell sample treatment device. Comprising a sealing ring film, the sealing ring film divides a containing cavity of the storage device into a first cavity and a second cavity which are not communicated with each other, the sealing ring film comprises a sealing body, a first opening blind seam, a second opening blind seam and a guiding notch, and the second opening blind seam corresponds to the first opening blind seam in position; and the guide notch is used for quickly breaking the sealing ring membrane and guiding the cell sample to be extruded in a vertical jet shape instantly after being pressed. According to the device, the sealing ring membrane can be broken through pressure in a completely closed state, cell samples are squeezed out of the discharge head of the storage device instantly in a jet state after being pressed and vertically injected into a sample tube needing to be mixed, the cell samples do not make contact with the external environment in the whole adding operation process of the cell samples, and therefore the cell samples are not prone to being mixed. It is greatly guaranteed that the cell samples are not polluted by the external environment, external pollution is avoided, and the sterile degree of sample treatment is improved.

The invention provides an interference avoidance scheduling method, network equipment, a terminal, a device and a storage medium, and the method comprises the steps that the network equipment determines the uplink interference state of each RRU in a multi-RRU cell based on the uplink IOT measurement result of the RRU, and / or determines the uplink interference state of each RRU in the multi-RRU cell based on the uplink IOT measurement result of the RRU; determining a downlink interfered state of each RRU in the multi-RRU cell based on a downlink rate related index of the terminal or a CSIIM interference value reported by the terminal; and performing interference avoidance scheduling based on the interfered state of each RRU. The problems of low resource utilization efficiency, limited cell capacity and the like caused by starting interference avoidance or interference randomization scheduling for the whole cell are avoided, and the resource utilization efficiency and the whole cell capacity can be effectively improved.

Disclosed in the present invention is an ultra-stable red fluorescent protein. The fluorescent protein disclosed in the present invention is a protein having an amino acid sequence of SEQ ID NO: 4. Experiments have demonstrated that the fluorescent protein has great tolerance to electron microscopy sample preparation, can retain more fluorescence signals after an osmium tetroxide treatment and can tolerate embedding in an Epon resin. Moreover, the fluorescent protein has great thermal stability and can retain more fluorescence signals even at 90°C. In addition, the fluorescent protein has relatively high chemical stability and light stability. On the basis of related properties of the fluorescent protein, the protein can be used in the fields of protein labeling, various types of fluorescence imaging, and super-resolution correlative light and electron microscopy, and used for tracking changes in structures and morphologies of samples such as proteins, subcellular organelles, local regions of a cell, and entire cells. The fluorescent protein can be used for packaging related viruses or generate transgenic animals, and for labeling specific proteins, specific organelles or specific cells, thereby achieving rapid tissue clearing imaging and expansion super-resolution microscopy.

The utility model discloses a cell resuscitation instrument capable of realizing accurate temperature control, which comprises a shell, a plurality of heating modules for cell resuscitation are arranged in the upper space of the shell at intervals, and each heating module comprises a heating groove for placing a cryopreservation tube. The temperature detection module is used for detecting temperature; the main control unit is used for triggering the heating module to heat the cryopreservation tube; the main control unit is electrically connected with the temperature detection module to realize timing control and temperature control of cell resuscitation; and a waste heat isolation device for blocking a heat source of the heated cryopreservation pipe is arranged in the heating tank. According to the structure, temperature control protection is achieved through the temperature detection module and the main control unit, accurate temperature control is achieved under the cooperation of the waste heat isolation device, multiple samples can be treated at the same time through the multiple heating modules arranged at intervals, the high-throughput experiment requirement is met, operation is easy in the whole cell resuscitation process, and sample pollution is avoided.

This disclosure relates to a solar cell module and its assembly method. The module includes multiple cells arranged in an array. At least one cell includes a cell, at least one diode, a separator film, a first connecting strip, and a second connecting strip. The diode is located on the back side of the cell. The separator film is located between the diode and the cell. A first end of the first connecting strip is electrically connected to a front solder strip of the cell, and a second end of the first connecting strip is electrically connected to a first electrode on the side of the diode facing away from the cell. A first end of the second connecting strip is electrically connected to a back solder strip of the cell, and a second end of the second connecting strip is electrically connected to a second electrode between the diode and the separator film. The first connecting strip surrounds a portion of the side surface of the diode and a portion of the side surface of the separator film. The second connecting strip surrounds a portion of the side surface of the separator film, which at least prevents the entire cell string from malfunctioning due to hot spot effects from individual cells.

In an upper-airspace staying type communication relay apparatus that performs an MU-MIMO radio communication with plural terminal apparatuses located in a cell, it is intended to improve the communication quality of the entire cell and enhance the system capacity, while suppressing an increase in overhead in the terminal apparatus and the communication relay apparatus even if the number of terminal apparatuses located in the cell increases. The communication relay apparatus receives an uplink signal from each of plural terminal apparatuses via an array antenna, estimates angle information indicating a direction of the terminal apparatus for each of the plural terminal apparatuses, selects a terminal apparatus to be assigned to each of plural radio resources used for a downlink based on the estimation result of the angle information, calculates a downlink beamforming weight based on the estimation result of the angle information, and transmits a downlink signal to the terminal apparatus via the array antenna based on the beamforming weight corresponding to the terminal apparatus and the radio resources assigned to the terminal apparatus.

Systems and methods for determining timing advance (TA) validity are disclosed. In some embodiments, systems and methods are disclosed herein in which a wireless device implicitly considers a TA to be valid in a full cell when no TA validation mechanisms are explicitly configured. In other embodiments, systems and methods are disclosed herein in which a timer serves a dual purpose. If the timer is set to infinity, a wireless device will always consider a TA to be valid within a given cell, and at the same time will disable other TA validation mechanisms. Otherwise, the wireless device will interpret the timer as indicating for how long the TA value that the wireless device possesses is considered to be valid. Benefits of the solutions described herein include reducing signaling bits in the configuration and avoiding the possibility of conflicting configurations.

A cell suction system includes a suction unit and a chip container holder. The suction unit includes a chip connection shaft to be connected to a chip base of a chip held in a chip container, and causes the chip to suck and hold a cell component of a cell or an entire cell from a needle tip of a needle portion, in a state in which the chip is connected to the chip connection shaft. The chip container holder holds the chip container so as to allow movement of the chip and the chip container relative to the chip connection shaft, to eliminate axial misalignment when the chip connection shaft is connected to the chip base of the chip held in the chip container.

Embodiments of the present invention provide a resource allocation method, apparatus, device, and computer-readable storage medium for an intelligent space-division cell cluster. For each divided cell in a space-division cell cluster, users belonging to each cell combination of the divided cell are first determined; then, an estimated total resource block requirement of the space-division cell cluster is obtained based on the estimated resource block requirements of users in each cell combination of each divided cell; and then, based on the number of available resource blocks in each divided cell and the estimated total resource block requirement of the space-division cell cluster, resource blocks are allocated to users in each cell combination of the divided cells in the space-division cell cluster, thereby avoiding interference as much as possible, improving spectrum efficiency, and maximizing the throughput of the entire cell cluster.