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Human skull repairing scaffold and preparation method thereof

A skull and human body technology, applied in the field of human skull repair stent and its preparation, can solve the problems of fusion, difficult autologous bone, cerebrospinal fluid leakage and even infection, and achieves the effect of small side effects, good mechanical properties, and promotion of skull growth.

Active Publication Date: 2012-01-04
周强 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is difficult to shape the titanium alloy mesh, which requires repeated punching; the temperature conductivity of the titanium alloy mesh is strong, and the patient is prone to intracranial discomfort, and it is not easy to fuse with the autologous bone; the edge of the titanium alloy mesh is sharp, and the scalp is thin. Patients are prone to complications such as scalp pain after surgery, and scratching the scalp by the edge of the titanium mesh will cause cerebrospinal fluid leakage or even infection

Method used

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Examples

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Effect test

preparation example Construction

[0041] The present invention also provides a preparation method of human skull repair bracket, comprising the following steps:

[0042] a) Using Mimics software to perform three-dimensional reconstruction on the CT scan data of the defect to obtain a three-dimensional image;

[0043] b) sequentially extracting contour lines and repairing damage to the three-dimensional image obtained in step a) to obtain a simulated repair image;

[0044] c) mold-free molding equipment presses and molds the biodegradable polymer sheet according to the simulated patch image obtained in step b), to obtain a skull plate;

[0045] d) adhering the bone growth factor to the surface of the skull plate obtained in the step c) to obtain a human skull repair bracket.

[0046] The present invention uses computer three-dimensional reconstruction and rapid prototyping technology to press the biodegradable polymer sheet into a skull plate, and then adheres bone growth factors to the surface of the skull pl...

Embodiment 1

[0071] 80g of medical-grade polylactic acid produced by Changchun Shengboma Biomaterials Co., Ltd. and 20g of hydroxyapatite grafted with oligomeric lactic acid on the surface were heated and blended at 180 ° C, and heated and pressed at 200 ° C to obtain a thickness of 0.5 mm. Sheet material; test the mechanical property of described sheet material, the result shows, its tensile strength 67Mpa, flexural strength 125Mpa;

[0072] Mechanically punching holes on the sheet, the hole diameter is 1mm, and the hole spacing is 3mm to obtain a polylactic acid sheet with through holes;

[0073] For those who are 30 years old and the area of ​​the skull defect is about 100×100mm 2 The CT scan was performed on the skull defect of the patient, and the scanned CT data was recorded on the CD in DICOM format; the CT data was imported with Mimics software, the gray threshold was adjusted, the region was dynamically grown, and impurities were removed to perform 3D reconstruction. The 3D data ...

Embodiment 2

[0078] Heat and blend 90g of medical-grade polylactic acid produced by Changchun Shengboma Biomaterials Co., Ltd. and 10g of hydroxyapatite grafted with oligomeric lactic acid on the surface at 180°C, heat and press at 200°C to obtain a sheet with a thickness of 1mm Material; Test the mechanical property of described sheet material, the result shows, its tensile strength 65Mpa, flexural strength 120Mpa;

[0079] Mechanically punching holes on the sheet, the hole diameter is 2mm, and the hole spacing is 5mm to obtain a polylactic acid sheet with through holes;

[0080] For those who are 45 years old and have a skull defect area of ​​about 100×100mm 2 The CT scan was performed on the skull defect of the patient, and the scanned CT data was recorded on the CD in DICOM format; the CT data was imported with Mimics software, the gray threshold was adjusted, the region was dynamically grown, and impurities were removed to perform 3D reconstruction. The 3D data is exported in STL for...

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Abstract

The invention provides a human skull repairing scaffold which comprises a skull plate formed by a biodegradable polymer and bone growth factors adhered to the surface of the skull plate. The invention also provides a preparation method of the human skull repairing scaffold. After the human skull repairing scaffold provided by the invention is implanted into a human body, the self skull of a patient grows along the surface of the skull plate under the promotion of the bone growth factors, so that the skull injury part heals; because the self skull grows along the surface of the skull plate, the shape of the grown skull coincides with the shape of the original skull, so that malformation and other phenomena are not generated; and in addition, because the skull plate is formed by the biodegradable polymer, after the self skull grows to obtain a complete skull, the skull plate is slowly degraded and discharged out through human body absorption, metabolism and other means, so that the repaired skull injury part is completely formed by the growth of the self skull, no any other foreign bodies are left in the human body, and no any adverse effects are caused to the patient.

Description

technical field [0001] The invention belongs to the technical field of skull repair, in particular to a human skull repair bracket and a preparation method thereof. Background technique [0002] Some brain neurosurgical diseases can cause intracranial high pressure and water, and usually need to remove part of the skull to achieve the purpose of reducing intracranial pressure and saving the patient's life; due to accidental brain trauma, infection, tumor and other diseases, brain surgery is required Surgery can also result in postoperative defects in the patient's skull. Skull defects make the brain tissue unprotected. When the patient lowers his head, the skull defect will cause encephalocele, and when the head is lifted, the brain tissue will collapse at the skull defect. In the case of the forehead, the impact on the patient's appearance and brain tissue is greater. In order to prevent further damage to the brain tissue, restore the airtightness of the cranial cavity, a...

Claims

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Application Information

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IPC IPC(8): A61L27/54A61L27/18A61L27/12G06F17/50
Inventor 周强陈学思庄秀丽崔毅高战团李少英
Owner 周强
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