33 results about "Skull repair" patented technology

The invention relates to the technical field of computer-aided skull repair prosthesis design and manufacturing, in particular to a computer-aided skull repair prosthesis design and manufacturing system. Comprising a form prediction unit used for solving an optimal form coefficient and generating an initial prosthesis form; the constraint evaluation unit is used for calculating to obtain a prosthesis conflict index and dividing conflict grades; the correction field generation unit is used for deconstructing a physical violation amount in response to the prosthesis conflict index, and solving and generating a dense displacement field covering all vertexes of the prosthesis through a form correction propagation model; and the closed-loop optimization unit is used for performing geometric deformation on the initial prosthesis form by applying the dense displacement field to obtain a corrected prosthesis form, and re-submitting the corrected prosthesis form to the constraint evaluation unit to execute a grading final edition strategy. According to the method, the contradiction between anatomical fidelity and clinical safety constraint in skull repair is solved by constructing a system comprising morphological prediction, constraint evaluation, correction generation and closed-loop optimization.

The invention provides modified PMMA bone cement powder and a preparation method thereof, modified PMMA bone cement and a preparation method and application thereof, and relates to the technical field of biomedical materials. The modified PMMA bone cement powder comprises 5-20 wt% of a modified magnesium-containing material, 3-7 wt% of an initiator and the balance of PMMA powder; the modified magnesium-containing material comprises a magnesium-containing material (magnesium or magnesium-zinc alloy powder) and an MgF2 layer coated on the surface of the magnesium-containing material. Bone cement added with the modified PMMA bone cement powder is used as a skull defect repair material, after implantation and solidification, through slow release of magnesium ions (which can contain zinc ions) in modified magnesium or magnesium-zinc alloy powder, on the basis of ensuring safety and effective skull repair, through multi-channel anti-inflammation (Mg < 2 + > (which can comprise Zn < 2 + >), hydroxyl and hydrogen synergistic anti-inflammation), the anti-inflammation effect is remarkable, and the anti-inflammation effect is good. And long-term stability of the structure can be guaranteed, and remarkable mechanical attenuation or structural failure is avoided.

The invention relates to a prosthesis used for being implanted into a defect area of a bone, and particularly discloses a skull repairing component which comprises a bone flap body used for being filled in the defect area of the skull, and the bone flap body comprises a disc-shaped filling body and a plurality of stimulation units. The plurality of stimulation units are circumferentially arranged between the outer disc surface and the inner disc surface of the filling main body, and each stimulation unit can protrude out of the side wall of the filling main body through radial movement; and the force application part is used for driving the stimulation units to radially protrude out of the side wall of the filling main body, so that after the bone flap body is filled in the defect area, the stimulation units are driven to stimulate the bone flap body. The force applying component drives the stimulation units to protrude out of the side wall of the filling body, so that the radial outer ends of the stimulation units are pressed against the side wall of the defect area to stimulate the bone body of the side wall of the defect area; and the positioning component is used for combining and positioning the bone flap body and the skull.

The invention belongs to the technical field of medicine, discloses a skull rapid growth marker and application thereof, and provides a skull rapid growth marker based on a pressure / dura mater FAK-Twist1 pathway and an application method of the marker in child skull defect repair. By detecting the expression level of the marker, the growth and development state of the pediatric skull can be accurately judged, and a scientific basis is provided for clinical doctors to select proper skull repair opportunities, so that the success rate and safety of pediatric skull defect repair operations are improved, and postoperative complications are reduced. The rapid skull growth markers determined by the invention are closely related to the growth and development mechanism of the child skull based on a pressure / dura mater FAK-Twist1 pathway, and the growth state of the skull can be accurately reflected by detecting the expression level of the markers, so that a reliable diagnostic basis is provided for opportunity selection of a child skull defect repair operation.

This invention relates to the field of cranioplasty materials, and particularly to a pediatric cranioplasty material, its preparation method, and its application. A method for preparing a pediatric cranioplasty material includes: acquiring cranial model data of a pediatric patient; obtaining a dense layer using 3D printing based on the cranial model data; placing a titanium mesh on the dense layer; wherein the titanium mesh comprises multiple titanium strips, each titanium strip having its two ends movably connected to the endpoints of two other titanium strips to form a titanium mesh, and each titanium strip rotating in the same plane about the movably connected point as an axis to extend or contract the titanium mesh; obtaining a porous layer using 3D printing on the dense layer and the titanium mesh based on the cranial model data, the dense layer and the porous layer encapsulating the titanium mesh to obtain the pediatric cranioplasty material. This invention provides a pediatric cranioplasty material, its preparation method, and its application, providing a cranioplasty material with strong mechanical properties and deformation capacity.

The invention discloses a functional structure improvement preparation method based on a PEEK skull repair material, and belongs to the technical field of skull repair materials. The PEEK skull repairing material comprises a PEEK skull repairing main body, a plurality of mounting holes, a plurality of first through holes and a plurality of second through holes, wherein the mounting holes are formed in the edge of the PEEK skull repairing main body at intervals; the first through holes and the second through holes are formed in the PEEK skull repairing main body at intervals; the first through hole is of an hourglass-shaped hole channel structure. The second through hole is of a needle nose structure; the PEEK skull repairing material is prepared by the following steps: performing 3D printing on a composite material which is obtained by compounding a carbon nano tube, hydroxyapatite, PEEK and a pore-forming agent and is used as a raw material, standing and extracting in acetone, and sequentially adding an N, N-dimethylformamide solution of poly (L-glutamic acid-L-cysteine), L-threonine-N-carbonyl anhydride and an N, N-dimethylformamide solution of a magnesium gallate metal organic framework, an N, N-dimethylformamide solution of a magnesium gallate metal organic framework into the 3D printing material for 3D printing to obtain the PEEK skull repairing material. And dipping in an N, N-dimethylformamide mixed solution to obtain the product.

The application discloses a porous structure skull prosthesis manufacturing method based on 3D printing and injection molding technology, relates to the technical field of skull defect repair prosthesis in neurosurgery, and comprises the following steps: performing three-dimensional reconstruction according to skull imaging data to obtain a skull three-dimensional model; manufacturing a male mold (also referred to as a convex mold) mold, a female mold (also referred to as a concave mold) mold and a porous sand structure according to the skull three-dimensional model; assembling the male mold mold, the female mold mold and the porous sand structure to be injection molded into a skull prosthesis model; and cooling, solidifying and sand cleaning the skull prosthesis model to obtain a skull repair prosthesis. The application is processed by means of CNC numerical control machining technology, injection molding technology and 3D printing technology, high-temperature injection molding is performed on a medical polymer material, and the skull repair prosthesis is obtained by removing the sand structure. The skull repair prosthesis can realize the ingrowth of scalp soft tissue, speeds up the skull repair and reconstruction process, and reduces the incidence of adverse reactions such as postoperative hydrops.

According to the preparation method of the PEEK-based tantalum coating skull restoration, the tantalum coating is prepared through data modeling, fused deposition modeling 3D printing and magnetron sputtering, the preparation process is simplified, and the production efficiency and the product consistency are improved. Medical-grade PEEK serves as a substrate, a micro-nano structure is formed on the surface through laser pretreatment, an ultrathin tantalum coating (the thickness is smaller than or equal to 1 micrometer) is deposited through magnetron sputtering, the matching degree of the appearance of the prosthesis and the anatomical appearance of a skull defect area reaches + / -1 mm, and the proximity error between the elasticity modulus of a bone contact area and a host bone is smaller than or equal to + / -10%.

The utility model relates to the technical field of medical instruments, in particular to a skull repair plate, which comprises an implantation main body provided with an inner surface and an outer surface which are opposite to each other; the through hole penetrates through the implantation main body; the temporomuscle suspension system is distributed on the implantation main body and comprises at least one group of temporomuscle suspension structures which are independent from the through hole and are not communicated with the through hole; the temporalis suspension structure comprises a first opening, a second opening and a channel, the first opening and the second opening are both located in the outer surface, the channel obliquely extends downwards from the first opening and then obliquely extends upwards to the second opening, the bottom wall of the channel is a plane, and a gap is formed between the bottom wall of the channel and the inner surface. According to the skull repair plate, the temporal muscle suspension system is arranged, the mechanical strength of the repair plate is considered, meanwhile, the skull repair plate can be suitable for suture curved needles with different arcs and radians, the suspension threading difficulty is reduced, the operation time is shortened, and the operation satisfaction degree of a patient is improved.

The utility model relates to medical instrument technical field, specifically disclose a skull repair device of integrated cerebrospinal fluid shunt, including artificial bone plate, be used for repairing skull defect, the outer surface of artificial bone plate is equipped with positioning recess, the positioning recess is used for accommodating cerebrospinal fluid shunt, and the positioning recess is equipped with the fixing assembly for fixing shunt. The utility model embeds the main part of cerebrospinal fluid shunt into artificial bone plate, makes shunt main part can accommodate in the thickness range of repair device itself, thereby significantly reduced the overall profile height of implant, effectively reduced the pressure and tension generated to scalp, can prevent the scalp erosion, breakage, necrosis and other serious complications caused by implant profile too high, simultaneously, through the fixing assembly to the shunt fixation, can effectively prevent the shunt from turning over or displacement after operation, guarantee the long-term stability and safety of drainage system, and simplify the operation.

The invention discloses a skull connecting and fixing system for fixing a skull repair patch, and relates to the technical field of medical instruments. The system comprises an upper locking piece, a lower locking piece and an expansion screw, and the fixing stability of the skull repairing piece is improved through a double fixing mechanism. The upper locking piece and the lower locking piece are in threaded connection to achieve primary longitudinal fixation, and the skull and the repairing piece are preliminarily locked; the expansion screw is inserted through a middle hole of the upper locking piece and expands, secondary transverse fixing is achieved, and the anti-loosening capacity is enhanced. The lower locking piece is provided with a retaining ring for a medical wire to penetrate through so as to lift and position the lower locking piece in the installation process. The upper locking piece and / or the lower locking piece are / is provided with elastic parts, each elastic part comprises a deformable groove position, and the elastic parts are opened under the action of the expansion screws to press the skull and the repairing piece. The expansion screw comprises an expansion structure and a screw, and when tightened, the expansion screw is opened to transmit force to the locking piece. The whole system is made of biocompatible materials, is suitable for craniocerebral surgery, and effectively solves the technical problem that a traditional skull fixing device is insufficient in stability.

The artificial skull structure comprises an artificial skull main body and a supporting foot, the supporting foot is connected to the periphery of the artificial skull main body and extends outwards, and the artificial skull main body is provided with an inner surface and an outer surface opposite to the inner surface. The projected area of the outer surface of the artificial skull body on a plane parallel to the skull surface is larger than the projected area of the inner surface of the artificial skull body. The supporting feet are arranged on the periphery of the artificial skull main body, so that a stable supporting point is provided for the artificial skull main body; the projected area of the outer surface of the artificial skull main body is larger than that of the inner surface of the artificial skull main body, so that the overall displacement resistance, collapse resistance and external impact resistance of the artificial skull main body are enhanced, and the safety of intracranial tissues is effectively protected.

This invention discloses a composite cranial repair bioprobe based on a 3D frame structure, comprising a 3D frame and biological patch units. The 3D frame includes an edge retention device and an internal main frame, each with a support platform. Each support platform houses the biological patch unit, which comprises a porous layer, a biomimetic layer, and a reinforcing layer arranged sequentially from the outside in. The porous layer has a porous structure with pores, the biomimetic layer is a biomimetic structure mimicking the trabeculae of the skull, and the reinforcing layer is a solid structure. The 3D frame portion of the composite cranial repair bioprobe provided by this invention sufficiently ensures the mechanical strength of the repair. The design of individual biological patch units, while meeting certain mechanical strength requirements, also ensures the integration of soft tissue and the ingrowth of host bone, guaranteeing the long-term stability of the repair.

The present application relates to the technical field of computer-aided skull repair prosthesis design and manufacturing, in particular to a computer-aided skull repair prosthesis design and manufacturing system. The system comprises a shape prediction unit for solving optimal shape coefficients and generating an initial prosthesis shape; a constraint evaluation unit for calculating a prosthesis conflict index and dividing a conflict level; a correction field generation unit for responding to the prosthesis conflict index, decomposing a physical violation amount, and solving a dense displacement field covering all vertices of the prosthesis through a shape correction propagation model; and a closed-loop optimization unit for applying the dense displacement field to geometric deformation of the initial prosthesis shape to obtain a corrected prosthesis shape, and re-submitting the corrected prosthesis shape to the constraint evaluation unit to execute a hierarchical final version strategy. The present application solves the contradiction between anatomical fidelity and clinical safety constraints in skull repair by constructing a system comprising shape prediction, constraint evaluation, correction generation and closed-loop optimization.

The utility model discloses a bone connection slip sheet structure, which relates to the field of skull repair of children, and comprises a repair component, the repair component consists of a fixed part and a sliding part, and the sliding part is embedded into the fixed part and is in sliding connection with the fixed part; according to the scheme, a slide way type bone connection mode is adopted, and compared with an existing titanium steel mesh fixing and repairing mode, the first repairing sliding piece and the second repairing sliding piece which are used for connection during skull repairing or long bone fracture connection can extend in a sliding mode, the firmness degree of connection between normal bones can be guaranteed, growth of the bones of children cannot be limited, and the safety of the children is improved. The bone repairing agent is very suitable for children bone repairing.

The utility model relates to a skull repairing body suitable for children. The skull repairing body comprises a covering part and an embedding part arranged on the lower surface of the covering part, the covering part comprises a contact area which is positioned above the embedding part and corresponds to the embedding part, and a plurality of extension parts which are distributed on the periphery of the contact area; wherein a containing cavity is formed between every two adjacent extension parts, and the containing cavities are used for installing non-rigid fixing devices. The utility model further relates to a skull repairing system comprising the repairing body. According to the skull repairing body, non-rigid fixation is adopted, the risk that rigid fixation possibly limits growth and development of the autologous skull and causes injury or infection is avoided, the covering part used for covering the autologous skull around the bone window is arranged, the repairing body obtains bearing force from the autologous skull, and the repairing body can be used for repairing the autologous skull. The problem that in the skull growth and development process of children, due to the fact that the defect area of the skull becomes large, fixing of the non-rigid fixing device fails, and then the skull repairing body falls off can be prevented.

The invention discloses a flexible conductive hydrogel stent with skull repairing and neural signal monitoring functions, which is prepared by taking polyvinyl alcohol-collagen-polylysine as a matrix, doping magnesium oxide nanoparticles and black phosphorus nanosheets, and finally performing freeze-induced phase separation and freeze-drying. The skull defect repair stent can be used as a skull defect repair stent to promote bone tissue regeneration, and can also be used as a flexible ECoG electrode to realize high-fidelity electroencephalogram signal monitoring.

The invention relates to the technical field of medical data processing, in particular to a skull repair implant material parameter configuration method and system, and the method comprises the following steps: obtaining the image data of a skull defect area, and determining the boundary information of skull defect based on the image data; according to the boundary information, obtaining physical attribute information of own bones adjacent to the boundary, and based on the physical attribute information, evaluating the bone regeneration capacity of an area adjacent to the boundary; determining skeleton regeneration potential distribution of each position in the skull defect area according to the skeleton regeneration capacity of the area adjacent to the boundary; performing unit division on the skull implant, and obtaining skeleton regeneration potential information corresponding to each unit of the implant according to the skeleton regeneration potential distribution; according to bone regeneration potential distribution of all positions in a skull defect area, material parameters of all units of the implant are finely configured, and precise matching of the degradation rate of the implant and the growth process of new bone tissue is achieved.

A high-purity magnesium skull repair mesh and its preparation method are disclosed, belonging to the field of biomedical materials. The repair mesh is made of high-purity magnesium with a purity of 99.95 wt%, and its surface roughness R... a,表面 The roughness R inside the pore is controlled within the range of 0.5~0.6 μm. a,孔 ≤ 0.8 μm. By precisely controlling the surface and internal roughness, a degradation rate of ≤0.2 mm / year was achieved for the repair mesh, a modulus ≥18 GPa after 12 weeks of implantation, and spontaneous disappearance of the degradation air bladder within 12 weeks, with a significant bone-promoting effect. The preparation method includes electrical discharge drilling, internal polishing, diamond wire slicing, and surface polishing. This invention solves the problems of excessively rapid degradation, poor morphological retention, and rapid decline in mechanical properties of existing magnesium-based cranial repair meshes, and is suitable for repairing bone defects in the skull, jawbone, radius, femur, and other bones requiring long-term mechanical support.

The utility model relates to a thickness-adjustable skull restoration body which is characterized by comprising an upper restoration piece and a lower restoration piece which are made of PEEK materials, the lower restoration piece is arranged below the upper restoration piece, the upper restoration piece is provided with a plurality of nail holes which penetrate through in the thickness direction and are used for rod portions of first screws to movably penetrate through, and the lower restoration piece is provided with a plurality of second nail holes which penetrate through in the thickness direction. The rod parts of the first screws penetrate through the corresponding nail holes and then are in threaded connection with the lower repairing piece, a distance is formed between the lower repairing piece and the upper repairing piece, the inner ends of the fixing plates are fixed to the edge of the upper repairing piece, and the outer ends of the fixing plates extend out of the upper repairing piece to be fixed to the skull. By selecting the first screws with different lengths, the distance between the lower repairing piece and the upper repairing piece can be changed, and then the overall thickness of the repairing body is adjusted.

The utility model discloses an elastic connecting assembly for skull repair. The elastic connecting assembly comprises an upper cover, a lower cover and a pressing assembly, wherein the upper cover and the lower cover are correspondingly arranged; the pressing assembly is fixedly connected with the upper cover and the lower cover; through holes are formed in the upper cover, the lower cover and the pressing assembly; the binding pieces penetrate through the through holes in sequence; installation can be completed only through two steps, auxiliary devices are not needed, convenience and rapidness are achieved, the connecting assembly can be automatically clamped during installation and pressing, operation is simple and easy to operate, meanwhile, after fastening, the fastening force is enhanced due to the pressing assembly, and stable fastening can be kept for a long time.

The utility model discloses a skull repairing mesh plate, and relates to the technical field of medical implants, the skull repairing mesh plate comprises a mesh plate main body, the mesh plate main body has a curved surface shape matched with a skull defect area; the screen plate main body is made of a composite material of polyether-ether-ketone and biphase calcium phosphate; the mesh plate main body comprises a compact area and a loose area, and the porosity of the compact area is smaller than that of the loose area; every two adjacent loose areas are separated through the corresponding dense areas, and the dense areas are staggered to form a net-shaped structure. First micropores are formed in the surface of the loose area; first through holes are formed in the compact area at intervals, and the first through holes are formed in the thickness direction of the screen plate body in a penetrating mode. The skull repairing screen plate has good mechanical properties; the bone integration capability is good; due to the lightweight design, foreign body sensation after implantation is reduced; the occurrence rate of subcutaneous hydrops can be reduced.

The invention provides an artificial skull restoration and relates to the technical field of biomedical materials, the artificial skull restoration comprises an inner layer, a middle layer and an outer layer which are sequentially connected from bottom to top, the inner layer is a compact structure layer, the middle layer comprises a compact frame structure and a porous loose structure, and the outer layer is a loose structure layer; the inner layer, the middle layer and the outer layer are all made of a first material or hydroxyapatite, and the first material is composed of polycaprolactone and beta-tricalcium phosphate. The artificial skull repair body provided by the invention not only has better biocompatibility and better mechanical property, but also has better degradation speed and new bone formation speed matching property, and can better promote skull tissue repair and regeneration.

The application discloses a skull prosthesis construction method and device and a storage medium. The method comprises the following steps: constructing a skull model to be repaired according to a skull medical image; constructing a first repair model according to the skull model to be repaired and a first thickness; constructing a second repair model according to a defect edge in the skull model to be repaired, a preset distance and a second thickness; and constructing a target prosthesis grid model according to the first repair model and the second repair model. Through the technical scheme of the embodiment of the application, the effect of constructing a stepped skull prosthesis is achieved, the fixing effect between the prosthesis and the skull is improved, and the risk of fixing the prosthesis and the skull is reduced.

1. The name of the design product: skull mesh. 2. The use of the design product: used as a skull repair mesh. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view 1.

The application discloses a skull repair fixing method, which comprises a drilling fixing part and a connecting part; the drilling fixing part comprises a drilling expansion fixing part; the drilling expansion fixing part is annular with an opening; the center position of the drilling expansion fixing part is a conical screw hole; two sides of the opening of the drilling expansion fixing part are respectively provided with bone flap fixing parts; after the drilling expansion fixing part is placed into a drilling hole on a skull, a screw is screwed into the conical screw hole, and the drilling expansion fixing part is clamped in the drilling hole after expansion; the two ends of the connecting part are respectively provided with a clamping groove for clamping a bone flap and a clamping groove for clamping a skull. The skull repair fixing method is simple in operation, does not need metal nail fixing, and has no additional protruding part on the skull, so that the mental state of a patient after operation is better.

The invention discloses an implantable nerve regulation and control system suitable for craniocerebral injury and a control method of the implantable nerve regulation and control system, and relates to the technical field of implantable medical instruments. The device comprises an implant and an in-vitro control patch. The implant can be independently implanted between the scalp and the skull or integrated on a functional layer in a groove in the dura mater side of a skull repair patch, and comprises an electrode array, induction coils in one-to-one correspondence and a control unit. The in-vitro patch comprises a transmitting coil array and a multi-channel driving circuit, is connected with the implant through wireless communication, and can perform independent regulation and control and self-adaptive power compensation on each channel according to a coupling state. The device can be implanted in a craniocerebral injury primary operation, so that the risk and treatment delay of a secondary operation are avoided. The invention further provides a corresponding closed-loop control method, and epilepsy suppression and exercise rehabilitation assistance are achieved through neural signal collection, abnormal event recognition, stimulation strategy matching and real-time adjustment.

The application discloses a flexible conductive hydrogel scaffold with functions of cranium repair and nerve signal monitoring, which is prepared from polyvinyl alcohol-collagen-polylysine as a matrix, doping magnesium oxide nanoparticles and black phosphorus nanosheets, and finally through freeze-induced phase separation and freeze drying. The application can be used as a cranium defect repair scaffold to promote bone tissue regeneration, and can also be used as a flexible ECoG electrode to realize high-fidelity brain electrical signal monitoring.

The invention relates to the technical field of medical care systems, in particular to a skull repair data analysis system and a skull repair data analysis method based on three-dimensional imaging. The repair protection effect is analyzed based on the damage condition of the brain tissue at the repair connection position, the repair quality is evaluated based on the repair effect obtained through analysis and the repair protection effect, then the skull repair quality is accurately estimated, the accuracy of skull repair quality analysis is improved, and the repair efficiency is improved. The repairing effect is comprehensively evaluated through the contour reduction degree and the connection degree of the repairing position and the nearby area, and the accuracy of repairing effect evaluation is improved.

The invention relates to the technical field of medical materials, and discloses injectable pH-responsive polypeptide antibacterial hydrogel for skull defect repair and a preparation method thereof, and the injectable pH-responsive polypeptide antibacterial hydrogel comprises oxidized cellulose, polypeptide, polyvinyl alcohol and exosome. The hydrogel is prepared from the oxidized cellulose, the polypeptide, the polyvinyl alcohol and the exosome, the hydrogel of a three-dimensional network structure is formed through interaction of polymer functional groups, the preparation process is simple and rapid, the reaction condition is mild, the prepared composite hydrogel has injectability, pH responsiveness and antibacterial activity, the exosome can be continuously released and controlled, and the hydrogel has a good application prospect. A new choice is provided for a skull repair material, and the application of the hydrogel in the field of bone repair is expanded.