Manufacturing method of surface modified artificial skull prosthesis

A technology of surface modification and production method, which is applied in the field of biomedical materials, can solve problems such as unsatisfactory cross-linking effect, failure to comprehensively consider soft tissue bonding performance, and the effect of low radiation dose, so as to avoid excessive water loss rate , easy to implement, and improve the effect of combination

Pending Publication Date: 2021-11-12
NINGBO CIBEI MEDICAL TREATMENT APPLIANCE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0011] 3. The patent directly and roughly judges that the cross-linking effect is not ideal under the condition of low irradiation dose through comparative experiments (paragraph 00192 of the specification), it only focuses on the degree of cross-linking and stability of collagen banding, without comprehensive consideration Its soft tissue bonding performance when applied to cranial prosthetic materials ignores the consideration of radiation dose rate and other factors, directly negating the effect of lower radiation dose

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  • Manufacturing method of surface modified artificial skull prosthesis
  • Manufacturing method of surface modified artificial skull prosthesis
  • Manufacturing method of surface modified artificial skull prosthesis

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Effect test

Embodiment 1

[0035] Embodiment 1 of the present invention provides a method for making a surface-modified artificial skull prosthesis, comprising the following steps in order:

[0036] Step S1 uses a 3D printer to print the solid PEEK skull restoration;

[0037] Step S2 Use a movable handle louver and sandpaper to polish the solid PEEK skull prosthesis until there are no obvious burrs and scratches, and then place it in 90% concentrated sulfuric acid for 1 minute in a water bath at 100°C to corrode the surface to form an etched surface. holes, the diameter of the pits is distributed in the range of 0.01-0.1mm; then ultrasonically cleaned in deionized water for 5 minutes, repeated 3 times; then placed in 75% ethanol for 5 minutes, finally taken out and placed in a sterile glass petri dish, room temperature Transfer to biosafety box after drying;

[0038] Step S3 Prepare a type I collagen solution with a concentration of 0.8 mg / mL in PBS buffer in a biosafety box, immerse the PEEK skull rep...

Embodiment 2

[0042] Embodiment 2 of the present invention provides a method for making a surface-modified artificial skull prosthesis, comprising the following steps in order:

[0043] Step S1 uses a 3D printer to print the solid PEEK skull restoration;

[0044] Step S2 Use a movable handle louver and sandpaper to polish the solid PEEK skull prosthesis until there are no obvious burrs and scratches, and then place it in 90% concentrated sulfuric acid for 1 minute in a water bath at 100°C to corrode the surface to form an etched surface. holes, the diameter of the pits is distributed in the range of 0.01-0.1mm; then ultrasonically cleaned in deionized water for 5 minutes, repeated 3 times; then placed in 75% ethanol for 5 minutes, finally taken out and placed in a sterile glass petri dish, room temperature Transfer to biosafety box after drying;

[0045] Step S3 Use PBS buffer solution to prepare type I collagen solution with a concentration of 1.2 mg / mL in the biosafety box, immerse the P...

Embodiment 3

[0049] Embodiment 3 of the present invention provides a method for making a surface-modified artificial skull prosthesis, comprising the following steps in order:

[0050] Step S1 Use a 3D printer to print a solid PEEK skull restoration;

[0051] Step S2 Polish the solid PEEK skull prosthesis with a movable louver and sandpaper until there are no obvious burrs and scratches, and then place it in 90% concentrated sulfuric acid in a water bath at 100°C for 1 minute to corrode the surface, and the surface corrodes to form corrosion pits. The diameter distribution of the pits is 0.01-0.1mm (such as figure 1 shown); then ultrasonically cleaned in deionized water for 5 minutes, repeated 3 times, then placed in 75% ethanol for 5 minutes, finally removed and placed in a sterile glass petri dish, dried at room temperature and transferred to a biological safety box;

[0052] Step S3 Prepare a type I collagen solution with a concentration of 1 mg / mL in PBS buffer in a biosafety box, imm...

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Abstract

The invention provides a manufacturing method of a surface modified artificial skull prosthesis, which comprises the following steps: 1, printing a solid PEEK skull prosthesis by using a 3D printer; 2, pretreating the PEEK skull prosthesis; 3, adsorbing and fixing type I collagen on the surface of the PEEK skull prosthesis through a physical effect to form a collagen adsorption layer; 4, carrying out crosslinking on the type I collagen by adopting Co-60 irradiation; and finally carrying out freeze vacuum drying. According to the method, the binding property of the PEEK material and the subcutaneous tissue can be remarkably improved, meanwhile, a chemical cross-linking agent is not used, the biocompatibility is good, the steps are relatively simple, and water resources are saved.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a method for making a surface-modified artificial skull prosthesis. Background technique [0002] Cranial defect is a common clinical disease in craniofacial surgery. The common repair methods include: titanium mesh repair, PEEK material repair, etc. The scientific name of PEEK material is polyetheretherketone (English poly-ether-ether-ketone, PEEK for short). It has the advantages of high specific strength, elastic modulus close to that of autogenous bone (no stress shielding), no artifacts in CT, no magnetism (can be used for nuclear magnetic resonance), low thermal conductivity (will not stimulate the human body due to changes in external environment temperature), etc. , the clinical feedback is excellent, and the market share is steadily increasing. [0003] However, PEEK materials have the following problems at this stage: [0004] 1. As a high molecular polym...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/28
CPCA61F2/2875A61F2240/001A61F2002/30985
Inventor 李久涵沈天威许铁松沈国成
Owner NINGBO CIBEI MEDICAL TREATMENT APPLIANCE
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