The invention relates to a nitrogen-doped titanium dioxide supported palladium catalyst for TADBIW hydrogenolysis debenzylation and preparation and application of the catalyst. The catalyst takes nitrogen-doped titanium dioxide as a carrier and palladium as an active component, the palladium is supported on the carrier, the doping amount of nitrogen is 0-10 wt.%, but not 0,of the total amount of the carrier, and the loading amount of the palladium is 0.1-10 wt.% of the total amount of the catalyst. The preparation method specifically comprises the following steps: (a) adding a titanium precursor into a solvent, stirring, adding a nitrogen source to form a mixture, stirring until the mixture is completely hydrolyzed, aging, and carrying out post-treatment to obtain a nitrogen-doped titanium dioxide carrier; and (b) adding the nitrogen-doped titanium dioxide carrier obtained in the step (a) into a solvent, stirring, adding a palladium precursor, stirring, adding a precipitator, adjusting the pH value to be alkaline, and performing post-treatment to obtain the nitrogen-doped titanium dioxide supported palladium catalyst. Compared with the prior art, the catalyst provided by the invention has the characteristics of high hydrogenolysis debenzylation reaction activity, high yield, high selectivity, good stability and the like.