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3D printed artificial skull repairing piece and preparation method thereof

A 3D printing and patch technology, applied in the field of 3D printed artificial skull patch and its preparation, can solve the problems of increasing the operation time, affecting the appearance, weakening the strength of the titanium alloy mesh plate, etc., to solve the problem of biocompatibility , The shape and size of the matching degree is high, and the effect of inducing the growth of bone cells

Active Publication Date: 2016-06-15
FOURTH MILITARY MEDICAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This kind of operation puts forward very high requirements for the doctor. The doctor must manufacture the restoration on the operating table as soon as possible according to the shape of the patient's skull defect. However, since the shape of each patient's skull defect is different, the restoration material titanium alloy is not easy to form. As a result, the titanium plate for skull repair prepared by hand does not fit well with the patient's skull defect, and some parts are sometimes warped, which affects the appearance; and repeated cutting of the titanium alloy mesh plate will weaken its strength and increase the use of titanium alloy screws. Increased cost of surgical treatment
Due to the need to repeatedly shape the titanium plate during the operation, the operation time is increased, the wound exposure time is increased, and the risk of postoperative infection is also increased. Once infection occurs, it may mean that the operation fails. The built-in skull repair titanium plate needs Take out, or need to operate again, which increases the trauma and economic burden of the patient

Method used

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  • 3D printed artificial skull repairing piece and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A method for preparing a 3D printed artificial skull repair patch specifically includes the following steps:

[0038] 1. Data Collection

[0039] Obtain the preoperative skull image data of the patient, and then input the data into the 3D software for 3D reconstruction, complete the design of the artificial skull patch, and obtain the 3D data of the artificial skull patch.

[0040] 2. Raw material preparation

[0041] 2.1 Grind the autogenous bone into powder at -15°C, and then pass through refined sieving to screen out the autogenous bone powder with a particle size of 100μm;

[0042] 2.2 Preparation of 0.2mol / L CaCl 2 Solution 20mL, according to the ratio of Ca / P molar ratio of 1.67, the CaCl 2 The solution was slowly dripped into 24mL of H with a concentration of 0.1mol / L 3 PO 4 In the solution, the pH value is adjusted to 7-10 with sodium hydroxide solution to form a gel of calcium hydroxyphosphate. After aging for 24 hours, it is washed and then dried in a drying oven at 105...

Embodiment 2~7

[0050] Examples 2~7 and Comparative Examples 1~6

[0051] The preparation method steps and mechanical properties test methods of Examples 2-7 and Comparative Examples 1-6 are the same as those of Example 1. The difference from Example 1 lies in the particle size of autologous bone powder (A) and the particle size of calcium hydroxyphosphate (B ), the mass ratio of autologous bone meal and calcium hydroxyphosphate (C) and the mass ratio of powder material to the volume of the dilute phosphoric acid (D), the specific parameters and mechanical properties are shown in Table 1:

[0052] Table 1

[0053]

[0054] Control sample

[0055] The steps of the preparation method and the mechanical property test method of the control sample are the same as those of Example 1. The difference from Example 1 is that the control sample only uses calcium hydroxyphosphate with a particle size of 120 μm as the raw material of the 3D printing powder without adding autogenous bone powder. The compressiv...

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Abstract

The invention provides an artificial skull repairing piece and a preparation method thereof. A 3D printing technology is adopted in the preparation method; autologous bone powder and hydroxyl calcium phosphate are used as basic raw materials of the artificial skull repairing piece, and thus the problem in biocompatibility of the artificial skull repairing piece is effectively solved; the outline dimension matching degree between the 3D printed artificial skull repairing piece and the defect part is high, and thus the working strength of doctors is greatly reduced; with good biocompatibility, the artificial skull repairing piece is conducive to inducing bone cell growth and promoting repairing; and due to high mechanical strength, the operation safety is improved.

Description

technical field [0001] The present invention relates to the field of artificial skull prostheses, and more specifically, to a 3D printed artificial skull prosthesis and a preparation method thereof. Background technique [0002] Skull defects caused by various reasons, such as craniocerebral trauma surgery or brain tumor surgery to remove the skull bone flap, due to the change in the shape of the skull defect area, the scalp is affected by the atmospheric pressure, causing its invagination to compress the brain tissue, seriously affecting brain function, and Without the protection of the skull, the brain is extremely vulnerable to re-injury. Therefore, it is necessary to perform cranioplasty 3-6 months after craniectomy. [0003] At present, the commonly used skull repair materials can be divided into two categories: autologous bone and artificial materials. Among them, autologous bone is mainly used for autologous bone transplantation. Although autologous bone has good b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/28A61L27/12A61L27/36
CPCA61F2/2875A61F2002/2835A61F2310/00293A61F2310/00359A61L27/12A61L27/3608A61L27/365A61L2430/02
Inventor 费舟罗百顺陈红庆袁玉宇
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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