Membrane slurry for implantable glucose sensor, and preparation method thereof

A glucose sensor and implantable technology, applied in the field of membrane slurry and its preparation, can solve the problems of reducing analyte concentration, increasing sensor production cycle and cost, etc.

Inactive Publication Date: 2021-09-10
CHANGZHOU VOCATIONAL INST OF ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, while the external coating film improves the biocompatibility of the sensor, it reduces the concentration of the analyte; the additional coating process also increases the production cycle and cost of the sensor.

Method used

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  • Membrane slurry for implantable glucose sensor, and preparation method thereof
  • Membrane slurry for implantable glucose sensor, and preparation method thereof
  • Membrane slurry for implantable glucose sensor, and preparation method thereof

Examples

Experimental program
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Embodiment 1

[0027] (1) Copolymerization of acrylic acid (AA) and thiobetaine methyl acrylate (SBMA) monomer solution: Weigh 2.21g of AA and 0.04g of SBMA monomer in turn in a polymerization bottle filled with a certain amount of 0.3M NaCl solution, shake to make it completely Dissolve, nitrogen gas at room temperature. After adding 0.0018g of potassium persulfate and sodium bisulfite (mass ratio: 2:1), the temperature was raised to a certain temperature (50°C), and the nitrogen flow was stopped after an obvious polymerization reaction occurred, and the reaction vessel was sealed. After 4 hours of reaction, the reaction was terminated with acetone. The product was soaked in acetone for 12 hours to remove unreacted monomers, and a white gel was obtained. After vacuum drying, a white powder was obtained. The product was about 1.7 g, and the yield was 76%. It was named p(SBMA-AA).

[0028] (2) Condensation and acylation reaction, take a 5mL centrifuge tube as the reaction vessel. First, p(S...

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Abstract

The invention discloses membrane slurry for an implantable glucose sensor, and a preparation method thereof. The structural formula of the membrane slurry is as shown in formula I (n is greater than or equal to 0 and less than or equal to 10). The membrane slurry has good biocompatibility; and meanwhile, electrons between enzyme electrodes can be transferred, the electrons firstly react with the reduction state of the enzyme, and then the electrons are rapidly transferred to the surfaces of the electrodes.

Description

technical field [0001] The invention relates to a membrane slurry and a preparation method thereof, in particular to a membrane slurry for an implantable glucose sensor and a preparation method thereof. Background technique [0002] With the improvement of living standards, diabetes has become a huge threat to people's health. Daily blood sugar monitoring is an important means to control the disease and prevent serious complications. In recent years, with the rapid development of microelectronics technology, implantable glucose sensors have received more and more attention. It can not only provide real-time blood glucose values, but also display the changing trend of blood glucose. Doctors can more easily give appropriate clinical information. Diagnosis and treatment options. [0003] But for implantable sensors, solving the biocompatibility of the device is the primary problem. The rejection of foreign bodies by the organism starts from the moment of implantation. First, t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/06C08F220/38C08F8/42G01N27/327G01N27/30
CPCC08F220/06C08F8/42G01N27/3277G01N27/308C08F220/387
Inventor 朱家辉常健杜浩然田文双代思佳乔奇伟周冰舸王晓东
Owner CHANGZHOU VOCATIONAL INST OF ENG
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