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A photodynamic therapy light guide system that can be used in human body cavity

A technology of photodynamic therapy and light guide system, which is applied in the medical field, can solve the problems of weakening of PDT treatment effect, achieve the effect of reducing heat energy, improving treatment effect and prolonging time

Active Publication Date: 2018-04-20
刘天军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

③Oxygen consumption during PDT treatment, 3 o 2 transform into 1 o 2 , accompanied by 1 o 2 The effect of PDT treatment is gradually weakened, and the lesion is a hypoxic tissue, so how to replenish oxygen at the irradiation site in time is another problem
[0006] How to solve the blindness and safety problems existing in the process of photodynamic therapy in the treatment of tissues and organs in the human cavity is the key to whether photodynamic therapy can break through the limitation of laser penetration depth on human tissues

Method used

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  • A photodynamic therapy light guide system that can be used in human body cavity
  • A photodynamic therapy light guide system that can be used in human body cavity
  • A photodynamic therapy light guide system that can be used in human body cavity

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Experimental program
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Effect test

Embodiment 1

[0029]See the accompanying drawings for details, a photodynamic therapy light guide system that can be used in the inner cavity of the human body, which is composed of a cylindrical optical fiber, a temperature control sleeve, a photosensitizer delivery sleeve and an oxygen delivery sleeve. The columnar optical fiber is composed of an optical fiber interface, an optical fiber transmission part and a scatterer, the optical fiber interface is a detachable interface, the wavelength connected to the laser is 650nm, the transmission part is an optical fiber, the length of the optical fiber is 5cm, and the diameter of the optical fiber is 2mm. The scatterer length is 3 cm. The temperature control sleeve is composed of a coolant inlet, a coolant outlet, a partition, and a water hole. The temperature control sleeve is made of transparent silicone rubber, and the diameter of the cavity is 8mm. The coolant inlet and the coolant outlet are externally connected Circulating water pump, tem...

Embodiment 2

[0032] See the attached figure for details, a photodynamic therapy light guide system that can be used in the inner cavity of the human body, consisting of point-shaped LED lights, temperature control sleeves, photosensitizer delivery sleeves and oxygen delivery sleeves. The dot-shaped LED lamp is composed of an optical fiber interface, an optical fiber conduction part and a scatterer, the optical fiber interface is a detachable interface, the wavelength of the connected laser is 630nm, the conduction part is an optical fiber, the length of the optical fiber is 8cm, and the diameter of the optical fiber is 1mm, the scatterer length is 5cm. The temperature control sleeve is composed of a coolant inlet, a coolant outlet, a partition, and a water hole. The temperature control sleeve is made of polycarbonate, and the diameter of the cavity is 1 cm. The coolant inlet and the coolant outlet are externally connected to the circulation Water pump, temperature control sensor, refrigera...

Embodiment 3

[0035] See the accompanying drawings for details, a photodynamic therapy light guide system that can be used in the inner cavity of the human body, which is composed of a cylindrical optical fiber, a temperature control sleeve, a photosensitizer delivery sleeve and an oxygen delivery sleeve. The columnar optical fiber is composed of an optical fiber interface, an optical fiber transmission part and a scatterer, the optical fiber interface is a detachable interface, the wavelength of the connected laser is 532nm, the transmission part is an optical fiber, the length of the optical fiber is 3cm, and the diameter of the optical fiber is 1mm. The scatterer length is 2 cm. The temperature control sleeve is composed of a coolant inlet, a coolant outlet, a partition, and a water hole. The temperature control sleeve is made of polymethyl methacrylate, and the diameter of the cavity is 6mm. The coolant inlet and the coolant The outlet is externally connected to a circulating water pump...

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Abstract

The invention discloses a photodynamic therapy light guide system applied to the human body cavity. The system is characterized by mainly comprising a columnar fiber (or dot LED lamp), a temperature control casing pipe, a photo-sensitizer conveying casing pipe, and an oxygen conveying casing pipe, wherein the columnar fiber is mainly composed of a fiber interface, a fiber conduction part and a scattering body, the temperature control casing pipe is composed of two communicated cylindrical cavities circulating up and down, the photo-sensitizer conveying casing pipe is composed of a hollow cylindrical cavity, and the oxygen conveying casing pipe is composed of a hollow cylindrical cavity. As a medical instrument, the photodynamic therapy light guide system of the system is of great potential value in the field of clinical inner cavity tumor and inflammation treatment. With the photodynamic therapy light guide system of the system, the problem of biological compatibility between the three elements (laser, photo-sensitizer, and oxygen) of photodynamic therapy and the human body cavity is solved fundamentally, the treatment time is prolonged, and the treatment effect is improved.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a photodynamic therapy light guide system for human body cavity, in particular to the combination of photodynamic reaction with in vivo temperature control technology, low flow rate oxygen supply technology and intracavity drug delivery technology. For the treatment of human internal cavity diseases, such as nasopharyngeal cancer, laryngeal cancer, gastric cancer, lung cancer, rectal cancer, colon cancer, bladder cancer, rhinitis, pharyngitis, tonsillitis, gastritis, pneumonia, oral ulcer, proctitis, colitis, Cystitis etc. Background technique [0002] Photodynamic therapy (PDT) is a minimally invasive tumor treatment technology emerging after surgery, radiotherapy and chemotherapy. It uses the selective intake and retention of photosensitizers by diseased cells to make them remain in the diseased tissue for a certain period of time. At this time, the laser of a specif...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61N5/06
CPCA61N5/062A61N2005/0604A61N2005/0627A61N2005/063
Inventor 刘天军洪阁
Owner 刘天军
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