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Skull repair polyether-ether-ketone material and preparation method thereof

A technology of polyether ether ketone and skull, which is applied in the direction of pharmaceutical formulations, prostheses, coatings, etc., can solve problems such as potential safety hazards and the process of surface modification of PEEK materials, and achieve the effect of easy access

Pending Publication Date: 2022-05-10
ASIA BIOMATERIALS WUHAN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of this application is to provide a polyether ether ketone material for skull repair and its preparation method to solve the problem of potential safety hazards in the current surface modification process of PEEK materials

Method used

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  • Skull repair polyether-ether-ketone material and preparation method thereof
  • Skull repair polyether-ether-ketone material and preparation method thereof

Examples

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preparation example Construction

[0039]According to a typical embodiment of the present invention, a preparation method of a polyetheretherketone material for skull repair is provided, the method comprising:

[0040] S1. Analyze the head to be repaired to obtain information on the skull defect;

[0041] S2. Polyetheretherketone is molded according to the information on the skull defect to obtain a matrix;

[0042] In some embodiments, the matrix can be made of polyether ether ketone two-dimensional braided material or made of polyether ether ketone material by 3D printing. The following description is only based on the preparation of the matrix by 3D printing:

[0043] First, perform CT plain and enhanced scans of the skull defect site, and then perform 3D reconstruction to determine the location, size, and shape of the skull defect; then import the scan data into the software to design the bone defect model, save it in STL format, and import it into a 3D printer. The software was used to correct and calibra...

Embodiment 1

[0076] A preparation method of a cranial bone repair polyetheretherketone material, the steps are as follows:

[0077] Obtain or make a polyetheretherketone material. Obtain polyetheretherketone two-dimensional braided material or obtain polyetheretherketone material by 3D printing. The method of 3D printing to prepare the polyetheretherketone material is as follows: first, the CT plain and enhanced scan of the skull defect site is performed, and then three-dimensional reconstruction is performed to determine the position, size, shape, etc. of the skull defect; then the scan data is poured into the software for bone defects Model design, save in STL format and import into 3D printer, use software to correct and calibrate the skull defect model, use digital equipment to shape according to the data of the model, and produce polyetheretherketone matching the defect site. The polyetheretherketone raw material meets the standard of YY / T 0660-2008 "Standard Specification for Polyet...

Embodiment 2

[0085] A preparation method of a cranial bone repair polyetheretherketone material, the steps are as follows:

[0086] Obtain or make a polyetheretherketone material. Obtain polyetheretherketone two-dimensional braided material or obtain polyetheretherketone material by 3D printing. The method of 3D printing to prepare the polyetheretherketone material is as follows: first, the CT plain and enhanced scan of the skull defect site is performed, and then three-dimensional reconstruction is performed to determine the position, size, shape, etc. of the skull defect; then the scan data is poured into the software for bone defects Model design, save in STL format and import into 3D printer, use software to correct and calibrate the skull defect model, use digital equipment to shape according to the data of the model, and produce polyetheretherketone matching the defect site. The polyetheretherketone raw material meets the standard of YY / T 0660-2008 "Standard Specification for Polyet...

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Abstract

The invention particularly relates to a skull repair polyether-ether-ketone material and a preparation method thereof, and belongs to the technical field of biomedical materials.The method comprises the steps that a head to be repaired is analyzed, and skull defect part information is obtained; forming polyether-ether-ketone according to the skull defect part information to obtain a matrix; the preparation method comprises the following steps: modifying a matrix by using the polydopamine nano-microspheres to obtain a modified matrix; mixing the calcium nitrate tetrahydrate solution, the diammonium hydrogen phosphate solution and the guided tissue regeneration layer solution to obtain a mineralized guided tissue regeneration layer solution; mixing a cross-linking agent, a modification matrix and the mineralization guided tissue regeneration layer solution to obtain a mixture; and reacting the mixture, drying, crosslinking, analyzing and sterilizing to obtain the skull repair polyether-ether-ketone material. Polydopamine nanoparticles are used for cross-linking modification of polyether-ether-ketone, raw materials are easy to obtain, safe and environmentally friendly, and hidden dangers brought to human bodies in the preparation process and the use of a final product are avoided.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, in particular to a cranial bone repair polyetheretherketone material and a preparation method thereof. Background technique [0002] Skull defect is a common secondary disease in clinical practice. Mainly seen in various trauma and postoperative, such as electric shock injury, car accident injury, bullet wound, skull malignant tumor resection, congenital deformity, decompressive craniectomy, etc. In principle, skull defects with a maximum diameter of more than 3 cm require skull reconstruction surgery. When the skull defect exceeds 3 cm, clinical symptoms can occur. Successful skull reconstruction needs to meet three requirements: (1) maintaining the integrity of the dura mater, that is, the protection of the brain; (2) protecting the barrier between the brain and the outside world, that is, biomechanical stability; (3) maintaining a normal head The dome-like shape is an aesthetic ...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/12A61L27/02A61L27/34A61L27/50A61L27/58
CPCA61L27/18A61L27/34A61L27/12A61L27/025A61L27/50A61L27/58A61L2400/12A61L2400/18A61L2430/02A61L2420/04C08L61/16C08L79/04C08L89/00
Inventor 唐三王喆周雄
Owner ASIA BIOMATERIALS WUHAN CO LTD
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