2 results about "Growth factor bone" patented technology

The present invention relates to a biomaterial comprising: —a membrane wound patch (a), made of a nanofibrous polymeric scaffold, —a hydrogel (b) including autologous or allogenic bone marrow-derived mesenchymal stem cells, and —a bone wound patch (c) being a nanofibrous scaffold made of polymers, wherein said scaffold has a surface coated with an interrupted coating made of multilayered droplets, said multilayered droplets being droplets composed of at least one layer pair consisting of a layer of polyanions and a layer of polycations, and wherein the bone wound patch (c) further comprises a bone growth factor; wherein the hydrogel (b) is included between the membrane wound patch (a) and the bone wound patch (c).

The application discloses a preparation method of a concentrated growth factor bone repair material for inducing macrophages to produce pro-osteogenic secretions and application thereof, and steps of the preparation method comprise the following steps: a, standardization preparation of a concentrated growth factor extraction liquid CGFe; b, screening and determination of 2*CGFe as an optimal concentration; c, verification of macrophage secretion induction and mechanism regulation; and d, preparation of a GelMA photocured composite hydrogel loaded with the CGFe. The concentrated growth factor bone repair material prepared by the preparation method is applied to bone defect repair. The prepared CGFe is used as a "biological switch", which can specifically inhibit a NF-kappa B signal path of macrophages and induce the macrophages to transform from a pro-inflammatory state to a repair state with abundant osteogenic factors. The concentrated growth factor bone repair material initiates an immune cell secretion-stem cell osteogenesis cascade regeneration reaction in situ in a body, and endogenous secretions are innovatively used to replace exogenous factors.