7 results about "Growth factor bone" patented technology

The invention discloses a titanium-based hydroxyapatite composite coating and a preparation method thereof. The problems that a traditional coating is weak in interface bonding, single in porosity and mismatched in drug sustained release are solved. The composite coating comprises a gradient component layer and a bionic porous outer layer which are sequentially stacked on the surface of a titanium substrate, wherein the gradient component layer comprises a bottom layer (a titanium-based hydroxyapatite transition layer, 70-80% of HA and bonded through Ti-O bonds) and a middle layer (an HA / bioglass composite layer, 50-70% of HA and 10-20% of bioglass); the bionic porous outer layer is a porous HA layer, the porosity is 40-60%, the porosity is gradually increased in a gradient mode in the direction away from the titanium substrate, surface layer pores are loaded with anti-infection drugs, and inner layer pores are loaded with bone growth factors. The method realizes improvement of the interface bonding strength of the coating, consideration of mechanical and biological activity and staged slow release of the medicine, and is suitable for the field of bone joint implantation.

The invention provides a bone repair material with a long-acting anti-inflammatory function. The bone repair material comprises a core material composed of an anti-inflammatory material, a first wall material composed of a biodegradable polymer and a second wall material composed of a biodegradable inorganic substance. The anti-inflammatory drug wall material is wrapped by two layers of wall materials, degradation of polylactic acid and release of the anti-inflammatory drug are delayed, a good anti-inflammatory effect is still achieved after 28 days, and the problem of inflammation occurring in the later period of degradation of polylactic acid can be effectively solved. Besides, the second wall material composed of biodegradable inorganic matters can be used as a bone growth factor, and particularly, the nano-hydroxyapatite has better biological activity, so that the growth of osteoblasts is more facilitated, and the bone repair cost can be reduced. The anti-inflammatory material with the core-shell structure is directly prepared from the synthesized polylactic acid, high-energy-consumption procedures such as partial drying are omitted, and the provided preparation method of the bone repair material has the advantages that the process is simple, the materials are easy to obtain, the effect is obvious and the like, and has good application prospects and market prospects.

The invention discloses a preparation method of a composite alveolar bone repair stent. The method comprises the following steps: mixing nano-scale hydroxyapatite powder and medical-grade PLA plastic powder according to a mass ratio of 10-20%: 1, melting and drawing wires to obtain a PLA / HAP wire for 3D printing, setting 3D printing parameters, introducing a bone repair scaffold three-dimensional model, starting printing to obtain a PLA / HAP composite material bone repair scaffold, soaking the scaffold in a 1-3mg / mL BMP bone morphological protein solution, and carrying out 3D printing to obtain the bone repair scaffold with the PLA / HAP composite material bone morphological protein / PLA / HAP composite material bone morphological protein / PLA / HAP composite material bone morphological protein / PLA / HAP composite material bone morphological protein composite material. The BMP-PLA / HAP composite material bone repair scaffold is obtained. The hydroxyapatite / PLA composite material prepared by adopting a 3D printing technology, taking the nano-scale hydroxyapatite powder and the medical-grade PLA plastic powder as raw materials and loading the BMP bone growth factor with high biological inductivity has high strength, high hardness and impact resistance, and can be used for preparing the medical-grade hydroxyapatite / PLA composite material. The invention aims to provide a safer and more effective bone graft material for clinically repairing alveolar bone defects.

A suture anchor includes an implanted portion configured to insert within an opening formed in bone of a patient and exposed portion configured to remain exposed. One or more sutures are laced through at least the implanted portion and possibly the exposed portion. Once tensioned, the suture causes the implanted portion to wedge within the opening and resist removal. The exposed portion may be placed over and / or around tissue and the suture may be passed through the tissue and knotted to secure the tissue to the suture anchor. The implanted portion may be infused with bone growth factors and the exposed portion may be infused with healing factors, such as Bone Morphogenic Protein-2 (BMP-2) and Platelet Rich Plasma (PRP).

The present disclosure provides implant materials comprising platelet-derived growth factor and a biocompatible matrix that are useful for bone repair, including bone fusion procedures and fracture repair.

The present invention relates to a biomaterial comprising: —a membrane wound patch (a), made of a nanofibrous polymeric scaffold, —a hydrogel (b) including autologous or allogenic bone marrow-derived mesenchymal stem cells, and —a bone wound patch (c) being a nanofibrous scaffold made of polymers, wherein said scaffold has a surface coated with an interrupted coating made of multilayered droplets, said multilayered droplets being droplets composed of at least one layer pair consisting of a layer of polyanions and a layer of polycations, and wherein the bone wound patch (c) further comprises a bone growth factor; wherein the hydrogel (b) is included between the membrane wound patch (a) and the bone wound patch (c).

The application discloses a preparation method of a concentrated growth factor bone repair material for inducing macrophages to produce pro-osteogenic secretions and application thereof, and steps of the preparation method comprise the following steps: a, standardization preparation of a concentrated growth factor extraction liquid CGFe; b, screening and determination of 2*CGFe as an optimal concentration; c, verification of macrophage secretion induction and mechanism regulation; and d, preparation of a GelMA photocured composite hydrogel loaded with the CGFe. The concentrated growth factor bone repair material prepared by the preparation method is applied to bone defect repair. The prepared CGFe is used as a "biological switch", which can specifically inhibit a NF-kappa B signal path of macrophages and induce the macrophages to transform from a pro-inflammatory state to a repair state with abundant osteogenic factors. The concentrated growth factor bone repair material initiates an immune cell secretion-stem cell osteogenesis cascade regeneration reaction in situ in a body, and endogenous secretions are innovatively used to replace exogenous factors.