Porous polyether-ether-ketone skull substitute and manufacturing method thereof

Abstract

The invention discloses a porous polyether-ether-ketone skull substitute and a manufacturing method thereof. The edge contour of the skull substitute is well matched with an autologous skull defect part, the skull substitute comprises a body entity and a porous structure, the body entity is of an arc porous structure, entity reinforcing ribs are additionally arranged, and the entity reinforcing ribs are obtained through topologic optimization; the porous structure comprises a braided structure, a through hole and a composition of the braided structure and the through hole, a threaded hole structure is arranged at the edge contour of the skull substitute, and installation and fixation are facilitated; according to the manufacturing method, the fusion deposition forming and selective laser sintering technology is adopted for preparing the porous polyether-ether-ketone skull substitute, due to post-treatment of the porous structure, the mechanical performance and biologic activity of theporous polyether-ether-ketone skull substitute can be improved, tissue around the substitute grows into the substitute, and biological fixation is achieved; after the porous polyether-ether-ketone skull substitute is planted into the body, the porous polyether-ether-ketone skull substitute can be well matched with the autologous skull defect part, installation and fixation are facilitated, and light-weight design of the skull substitute and weakening of foreign body sensation of the substitute are achieved.

Description

technical field [0001] The invention relates to the technical field of biomanufacturing, in particular to a porous polyether ether ketone skull substitute and a manufacturing method thereof. Background technique [0002] Blows, falls, traffic accidents, tumor resection, etc. will cause skull injuries. When the defect diameter is greater than 3cm, the skull will lose the barrier function of the normal skull, dizziness, memory loss, etc., affecting the life of the patient. Cranioplastic surgery can avoid re-injury of the brain in patients with craniocerebral injury, treat skull defect syndrome, and reduce the mental burden of patients. [0003] Existing cranioplasty includes autologous bone reconstruction and skull substitute reconstruction (titanium alloy, titanium plate, plexiglass, polyether ether ketone, etc.), and the above-mentioned cranioplasty has inherent defects, for example, the source of autologous bone reconstruction materials is limited, It will cause damage to ...

AI Technical Summary

Problems solved by technology

[0003] Existing cranioplasty includes autologous bone reconstruction and skull substitute reconstruction (titanium alloy, titanium plate, plexiglass, polyether ether ketone, etc.), and the above-mentioned cranioplasty has inherent defects, for example, the source of autologous bone reconstruction materials is limited, It will cause damage to the sampling site; titanium alloy substitutes have problems such as heat sensitivity, medical artifacts, and titanium mesh is easy to deform when repairing large-area defects; polyetheretherketone benefits from its elastic modulus similar to bone and excellent chemical stability With the advantages of high stability, excellent wear resistance and radiolucency, polyether ether ketone has become one of the most promising bone substitute materials.

However, the cost of PEEK materials is high, and traditional processing methods (injection molding, compression molding, machining) will further increase the cost of use; the biological inertia of PEEK materials does not have good osteoinductive and osseointegration properties , Polyetheretherketone skull substitutes with solid structure are not conducive to bone growth and are not conducive to osseointegration of autologous bone and substitute

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