The invention discloses a multi-objective optimization design method for a wheel, relates to the technical field of vehicle engineering and aims at solving the problems that the optimization space is limited and automatic optimization design is not carried out through joint transferring of calculation software with various properties due to the fact that only limited performance of the vehicle is analyzed and optimized and parametric modeling is lost at present. The method comprises the steps of topological optimization of a wheel fatigue test, combined topological optimization modeling, fatigue performance analysis, impact performance analysis, aerodynamic performance analysis and multi-objective optimization. Five working conditions of a dynamic bending fatigue test of the wheel, a dynamic radial fatigue test, an impact test of an impact hammer opposite to a spoke, an impact test of the impact hammer opposite to a window and air dynamics analysis of the wheel are set; the properties, such as the strength, the rigidity, the vibration characteristic, the fatigue life, the fatigue life security coefficient, the impact performance, the air dynamic property and the lightweight performance of the wheel are comprehensively considered; various performance parameters are calculated through finite element software emulation; and optimization design is carried out on the wheel by setting the performance parameters to be constraint conditions or objective functions.