Paste-like bone cement

A free-radical, monomeric technology, applied in prosthesis, surgery, tissue regeneration, etc., can solve problems such as the contribution to the mechanical stability of pasty cement

Inactive Publication Date: 2014-02-12
HERAEUS MEDICAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] However, one problem is that the cross-linked polymer particles used

Method used

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  • Paste-like bone cement
  • Paste-like bone cement
  • Paste-like bone cement

Examples

Experimental program
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Embodiment Construction

[0014] The present invention is based on the discovery that well-formed and formed bone cements can be prepared by using particulate inorganic calcium salts from molecular sieve fractions smaller than 63 μm (according to DIN 66165-1 / -2), With methyl methacrylate bone cement, that was an accident. The surprise is that the hitherto customary crosslinked polymer particles which are insoluble in methacrylate monomers can be completely or partially replaced by particulate inorganic calcium salts. Inorganic calcium salts are considerably cheaper than crosslinked polymer particles and can thus be used economically and advantageously in the production of pasty polymethylmethacrylate bone cements. Surprisingly, it was found that calcium carbonate, in particular from molecular sieve fractions smaller than 63 μm, is particularly suitable as filler.

[0015] Inorganic calcium salts such as calcium carbonate have relatively low hardness. Calcium carbonate (calcite) is therefore character...

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Abstract

A paste contains at least one monomer for radical polymerisation, at least one polymer that is soluble in said at least one monomer for radical polymerisation, and at least one filling agent that is poorly soluble or insoluble in said at least one monomer for radical polymerisation. The filling agent is a particulate inorganic calcium salt comprising the following properties: at least 90% by weight of the particulate inorganic calcium salt have a particle size of less than 63 mum, as determined by means of sieve analysis; and the solubility in water of the particulate inorganic calcium salt at 20° C. is less than 8.5 g per litre. A kit and the paste is usable for mechanical fixation of articular endoprostheses, for covering skull defects, for filling bone cavities, for femuroplasty, for vertebroplasty, for kyphoplasty, for the manufacture of spacers or for the production of carrier materials for local antibiotics therapy, as well as a form body.

Description

technical field [0001] The invention relates to a paste, kit, paste or paste prepared from a kit for mechanical fixation of joint prostheses, for covering skull defects, for filling bone cavities, femuroplasty, vertebroplasty, kyphoplasty for surgery, for the preparation of spacers or for the preparation of carrier materials for topical antibiotic therapy, and for form bodies. Background technique [0002] Traditional polymethylmethacrylate bone cement (PMMA bone cement) has been around for decades and is based on the groundbreaking work of Sir Charnley (Charnley, J.: " Anchorage of the femoral head prosthesis of the shaft of the femur "; J. Bone Joint Surg. 42 (1960) 28-30). Since then, the basic structure of PMMA bone cement has remained unchanged. PMMA bone cement consists of a liquid monomer component and a powder component. The monomer component is usually Contains (i) a monomer, methyl methacrylate, and (ii) an activator (eg, N,N-dimethyl-p-toluidine) dissolved therei...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L27/44A61L24/06A61K47/32C08F4/00C08F20/10
CPCA61L24/043A61L27/46A61L24/0073A61L2430/02A61L24/0084A61L24/0089C08L33/08
Inventor S.福格特
Owner HERAEUS MEDICAL
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