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Skull defect restoration titanium mesh with nonsticking coating and preparation method thereof

An anti-adhesion coating and anti-adhesion coating technology, which is applied in coatings, medical science, prostheses, etc., can solve problems such as the inability to overcome the adhesion of meninges and skull defect repair materials, so as to avoid adhesion, avoid direct contact, no toxic side effects

Inactive Publication Date: 2011-10-19
上海双申医疗器械股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the skull defect repair material of the above-mentioned patent cannot overcome the adhesion problem between the meninges and the skull defect repair material after surgery, and the titanium mesh needs to be shaped in clinical use, and the peeling off of the coating after shaping needs further improvement.

Method used

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  • Skull defect restoration titanium mesh with nonsticking coating and preparation method thereof
  • Skull defect restoration titanium mesh with nonsticking coating and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0020] (1) preparation concentration is the polybutylmethacrylate tetrahydrofuran solution of 5wt%, adopts the method for spraying, coats the bottom layer on the inner surface of the titanium net, medium flow rate 2ml / min, spraying time 120 seconds, dry, in the titanium net Form a bottom layer on the surface, dry at 30°C for 24 hours;

[0021] (2) Prepare a hyaluronic acid aqueous solution with a concentration of 15wt%, and apply it on the bottom layer by spraying, with a medium flow rate of 2ml / min and a spray time of 120 seconds, then dry it in the air and dry it at 20°C for 12 hours, so that the bottom layer A firm soft hyaluronic acid layer is formed on the surface to obtain the titanium mesh for repairing skull defects with an anti-stick coating.

Embodiment 2

[0023] (1) preparation concentration is the glycolide dimethylformamide solution of 1wt%, adopts the method for spraying, coats the bottom layer on the inner surface of the titanium mesh, medium flow rate 5ml / min, spraying time 180 seconds, dry in the air, on the titanium mesh Form a bottom layer on the inner surface, dry at 35°C for 30 hours;

[0024] (2) Prepare a hyaluronic acid aqueous solution with a concentration of 2wt%, and apply it on the bottom layer by spraying, with a medium flow rate of 5ml / min and a spraying time of 150 seconds, dry it in the air, and dry it at 25°C for 24 hours, so that the bottom layer A firm soft hyaluronic acid layer is formed on the surface to obtain the titanium mesh for repairing skull defects with an anti-stick coating.

Embodiment 3

[0026] (1) Prepare a sodium alginate aqueous solution with a concentration of 10 wt%, and apply a bottom layer on the inner surface of the titanium mesh by spraying, with a medium flow rate of 1ml / min, spray for 60 seconds, and dry to form a bottom layer on the inner surface of the titanium mesh , dried at 35°C for 48 hours;

[0027] (2) Prepare a hyaluronic acid aqueous solution with a concentration of 10wt%, and apply it on the bottom layer by spraying, with a medium flow rate of 2ml / min and a spray time of 120 seconds, then dry it in the air and dry it at 20°C for 12 hours, so that the bottom layer A firm soft hyaluronic acid layer is formed on the surface to obtain the titanium mesh for repairing skull defects with an anti-stick coating.

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Abstract

The invention provides a skull defect restoration titanium mesh with an anti-sticking coating and a preparation method thereof, wherein the skull defect restoration titanium mesh comprises a titanium mesh, a bottom layer coated on the internal surface of the titanium mesh, and an anti-sticking coating coated on the bottom layer; and the anti-sticking coating is hyaluronic acid. Compared with the prior art, the titanium mesh and the preparation method have the advantages that during the initial recovering process of a patient after operation, the direct contact between meninges and the titanium mesh can be avoided, thus avoiding the conglutination between the meninges and the titanium mesh; during the later recovering stage, the bottom layer and the hyaluronic acid are gradually absorbed by a human body, and other side effects are not generated. In the invention, the hyaluronic acid has good biocompatibility and can be naturally absorbed and metabolized by organisms after a certain time interval; and the toxic side effects are not generated.

Description

technical field [0001] The invention relates to a skull defect repair material, in particular to a titanium mesh. Background technique [0002] The skull is one of the most important parts of the human skeleton. Once the skull is damaged, it will cause or bring great pain, which will not only affect the appearance, but also cause various sequelae. [0003] Currently, the materials used for the repair of skull defects are: [0004] plexiglass, hydroxyapatite (HAP) and titanium mesh, etc., the defects of the materials are obvious, plexiglass has poor biocompatibility, although hydroxyapatite (HAP) has better biocompatibility, it is easily absorbed by the human body Absorption, strength decreases with time, such as a skull repair material disclosed in Chinese patent 98120303.5. [0005] Chinese patent, application number: 200810066623 discloses a titanium mesh made of titanium material with a bionic coating. The titanium mesh for skull defect repair includes a titanium mesh s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/50A61L27/06
Inventor 潘留国刘正永陈詠何茂明刘建芳
Owner 上海双申医疗器械股份有限公司
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