Mineralized collagen-based skull defect restoration based on digital reconstruction and preparation method of skull defect restoration

Abstract

The invention relates to a mineralized collagen-based skull defect restoration based on digital reconstruction and a preparation method of the skull defect restoration. The preparation method comprises the following steps: acquiring skull image data of a patient; conducting threshold setting and a region growing operation, so that a three-dimensional skull model is obtained; establishing a curve model which is matched with a part of skull defect and has an internal repair curve and an external repair curve; leading the curve model into digital model engraving software and conducting detail treatment; suturing the internal repair curve and the external repair curve into an enclosed solid, so that a restoration model is constituted, and conducting a Boolean operation on the restoration model and the three-dimensional skull model, so that the edge of the restoration model is consistent with a skull defect edge; conducting a rollover operation on the restoration model and processing a solid mold; and pouring a mineralized collagen/polycaprolactone mixed suspension into the mold and conducting molding, so that the mineralized collagen-based skull defect restoration is obtained. According to the skull defect restoration and the preparation method thereof provided by the invention, perfect fit between the restoration edge and the skull defect edge is achieved, and moreover, new bone growth is guided, so that a post-operative skull curing effect is guaranteed.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a mineralized collagen-based skull defect repair body based on digital reconstruction and a preparation method. Background technique [0002] Skull defects are mostly secondary to open craniocerebral injury, surgical intracranial decompression, tumor resection, congenital malformations, and progressive skeletal diseases after craniotomy, which is a common sequelae after craniocerebral surgery. Because the brain tissue loses the barrier function of the normal skull, it is more vulnerable to injury. At the same time, the skull defect will cause various symptoms and affect the appearance, causing great damage to the life and psychology of the patient. If the diameter of the skull defect is greater than 3cm, it will cause physical and psychological symptoms such as dizziness, headache, depression, irritability, poor self-control and restlessness. Large-area skull defects can...

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