The invention belongs to the technical field of medical instruments, and particularly relates to a skull milling cutter for craniotomy. The skull milling cutter comprises a shell; a first sliding holeis formed in the shell, a first drill rod is rotationally connected into the first sliding hole, and a second drill rod is slidably connected into a first hole formed in the first drill rod; a firstsliding groove is formed in the first hole, a sliding block is slidably connected into the first sliding groove, and the sliding block is fixedly connected with the first drill rod; a sliding cavity is formed in the first hole, a limiting ring is fixedly connected to the position, corresponding to the sliding cavity, of the first drill rod, and the second drill rod on the side, away from the sliding block, of the limiting ring is sleeved with a reset spring; a groove is formed in the position, corresponding to the sliding block, in the first hole, an obliquely-arranged second sliding groove isformed in the groove, and a rotating pin is connected into the second sliding groove in a sliding mode; and a second sliding hole is formed in the position, corresponding to the second sliding groove, of the second drill rod, a sliding column is slidably connected into the second sliding hole, and the end, close to the rotating pin, of the sliding column is fixedly connected with the rotating pin. Accurate positioning is achieved through the second drill rod, and the drilling accuracy of the skull milling cutter is guaranteed.