203 results about "Polyvinyl alcohol hydrogel" patented technology

The invention is directed to methods of making novel porous and solid polyvinyl alcohol hydrogels. These hydrogels are particularly suited for use in the replacement and augmentation of soft tissue or non-load bearing bone of the face, head and cranium.

Reinforced, laminated, impregnated, and materials with composite properties as cross linked polyvinyl alcohol hydrogel structures in bulk or cellular matrix forms that can take essentially any physical shape, or can have essentially any size, degree of porosity and surface texture. They have a wide range of physical properties, unusual and unique combinations of physical properties and unique responses to stress fields, which allows for their use in many end use applications.

The invention produces polyethylene alcohol hydrogel dressing containing medicine and chitosan with 60Co gamma-radial or high energy electron beam radial cross linking. Additional, adds in some humectant, plasticizer, medicine, the solvent is the secondary distilled water, physiological saline or phosphate neutral buffer liquid. The product can release medicine slowly and has natural amylose chitosan with biology sterilization activity, it has active sterilization function, at the same time, it has high water quantity, and good water reserving performance, the mechanical intensity is moderate, and the light penetration and air penetration are excellent. It can accord the demands for curing each kind of wound. It can used as the permanent dressing for light skin injuries, and it also can be applied to the temporally close of severe skin organization wound or burn wound.

The invention provides a preparation method of a flexible polyaniline conductive composite hydrogel material, and belongs to the technical field of functional polymer materials. According to the method, a flexible conductive material with good mechanical strength and electrochemical property is prepared by utilizing the properties and characteristics of polyatomic acid of phytic acid, by taking the phytic acid as an acid doping agent and a gel crosslinking factor and taking polyvinyl alcohol hydrogel as a skeleton. The method comprises the following steps: dissolving polyvinyl alcohol into water to form a solution and matching the solution with phenylamine and phytic acid at a proportion to form a solution A; dissolving initiating agent ammonium persulfate into water to form a solution B; quickly mixing the solution A and the solution B at a low temperature, so that in situ polymerization is performed on the phenylamine in a polyvinyl alcohol aqueous solution, so as to form phytic acid-doped polyaniline hydrogel; placing the phytic acid-doped polyaniline hydrogel into a refrigerator for freezing, so as to form the flexible polyaniline conductive composite hydrogel material by a cyclic freeze thawing. The flexible polyaniline conductive composite hydrogel material prepared by the method has good electrochemical property, mechanical strength and flexibility; the preparation method is simple, and the cost is low, and the preparation method has wide application prospect in the fields of flexible energy storage materials and biomedicine.

The invention relates to a preparation method for a grain size controllable monodisperse polyvinyl alcohol gel microsphere. The preparation method comprises the following steps: preparing a disperse phase solution and a continuous phase solution; controlling the flowing speed, flow and viscosity of the disperse phase and the continuous phase; obtaining polyvinyl alcohol solution drops in different grain sizes and in uniform diameter size after converging the disperse phase with the continuous phase; and solidifying the drops, thereby obtaining the grain size controllable monodisperse polyvinyl alcohol gel microspheres. The invention also relates to a preparation device for the grain size controllable monodisperse polyvinyl alcohol gel microsphere and the prepared monodisperse polyvinyl alcohol gel microsphere. The microsphere prepared according to the invention has a better surface morphology and a grain size range of 50-600 microns. The preparation device is convenient to assemble and disassemble; the size controllable preparation for a monodisperse polyacrylamide microsphere is realized by changing the size of a capillary tube or controlling the flowing speed or viscosity of the disperse phase and the continuous phase; and the grain size distribution coefficient CV is less than 5%.

The invention discloses a method for preparing a high-strength polyvinyl alcohol hydrogel. The method comprises the following steps: taking polyvinyl alcohol as an initial raw material, and heating and dissolving in a water bath, thereby obtaining a polyvinyl alcohol aqueous solution; performing repeated low-temperature freezing-thawing on the polyvinyl alcohol aqueous solution, thereby obtaining polyvinyl alcohol hydrogel; adding the polyvinyl alcohol hydrogel into a saturated saline solution, thereby obtaining the high-strength polyvinyl alcohol hydrogel. According to the invention, a hydrogen bond cross-linking structure and a microcrystalline domain are sequentially constructed by a two-step method, and then the high-strength polyvinyl alcohol hydrogel is prepared. The preparation method disclosed by the invention is simple and environmental-friendly, and the prepared high-strength polyvinyl alcohol hydrogel has excellent mechanical property, non-toxicity and high biocompatibility.

The invention discloses polyvinyl alcohol/inorganic nanocomposite hydrogel, which is characterized by being formed by the following components: 30-90 parts by weight of polyvinyl alcohol and 0.1-20 parts by weight of inorganic nanocomposite particles through a chemical crosslinking gel method, wherein the inorganic nanocomposite particles comprise nano clay, nano mica powder, a nano molecular sieve, nano wollastonite, nano graphite, nanosilicon dioxide or a carbon nano tube. With the adoption of the polyvinyl alcohol/inorganic nanocomposite hydrogel, the mechanical strength of polyvinyl alcohol hydrogel is enhanced on the basis of not influencing the moisture of the hydrogel, the service life is prolonged, the permeability of the polyvinyl alcohol hydrogel is improved, and a channel is reserved for transmission of matters. As the selection of the materials, the production cost is controlled, and the better economic benefit is brought. The invention also discloses a preparation method of the polyvinyl alcohol/inorganic nanocomposite hydrogel. The preparation method is simple and feasible to operate and good in mechanical strength, and can be produced industrially.

The invention provides novel functionalized polyvinyl alcohol hydrogel capable of adsorbing heavy metal ions and a preparation method of the novel functionalized polyvinyl alcohol hydrogel. The hydrogel comprises functionalized polyvinyl alcohol (PVA), chitosan (CS) and sodium alginate, wherein the weight ratio of the functionalized polyvinyl alcohol to the chitosan ranges from (5:95) to (95:5). The prepared hydrogel has the large adsorption capacity on heavy metal and is high in adsorption speed. The hydrogel is prepared by the following steps: functionalizing the polyvinyl alcohol and completely mixing the functionalized polyvinyl alcohol and the sodium alginate to be dissolved in water; then adding a certain amount of the chitosan and uniformly mixing; and finally, dripping mixed liquid into a calcium chloride-boric acid saturated solution to prepare hydrogel globules. The composite hydrogel provided by the invention is simple in preparation process, strong in operability and stable in performance, can be circularly utilized, has no secondary pollution and is widely applied to the field of heavy metal sewage treatment.

The invention belongs to the technical field of intelligent high-molecular materials, and relates to a preparation method and an application of a high-strength oriented polyvinyl alcohol hydrogel. Thepreparation method of the high-strength oriented polyvinyl alcohol hydrogel comprises the following steps: adding deionized water to dissolve polyvinyl alcohol powder, carrying out freeze-thawing circulation, pre-stretching orientation and freeze drying to obtain a polyvinyl alcohol aerogel, and immersing the obtained polyvinyl alcohol aerogel in an aqueous solution of a salt having a Hofmann effect or an aqueous solution of a salt capable of forming a coordinate bond or an aqueous solution of a polycarboxy compound capable of forming a hydrogen bond with polyvinyl alcohol to prepare the high-strength oriented polyvinyl alcohol hydrogel. The high-strength oriented polyvinyl alcohol hydrogel has a tensile strength reaching up to 41.0 MPa, an elongation at break reaching up to 228.0% and atoughness reaching up to 49.94 MJ/m<3>, also has antibacterial and anticorrosive effects and a free radical scavenging effect, and is of great significance to broaden the application of the polyvinylalcohol hydrogel in artificial muscles and cartilages, tissue engineering and other biomedical materials.

A composite artificial joint with artificial cartilage structure features that an artificial cartilage structure layer made of polyvinyl alcohol hydrogel is arranged on the end face of a mechanical supporting unit, which may use a composite material structure body made of nano-hydroxy apatite and/or medical high-molecular material and/or porous mechanical supporting structure and contains the chtosan sponge carrying growth factor. The connection end of mechanical supporting unit and base bone has at least one convex fixing structure.

The invention relates to polyving alcohol composite hydrogel and a preparation method thereof. The polyving alcohol composite hydrogel is prepared from the following raw materials in parts by weight through cross-linking solidifying compounding of boric acid solution containing solidifier: 30 to 90 parts of polyving alcohol, 0.1 to 50 parts of sodium alginate, 0.1 to 20 parts of inorganic nanoparticles, 1 to 20 parts of elastomer material, 0.5 to 5 parts of coupling agent and 200 to 2000 parts of water, wherein the degree of polymerization of polyving alcohol is 400 to 3000, and the alcoholysis degree is 75 to 99 percent. The polarity elastomer material and the inorganic nanoparitcles which are processed through the coupling agent are compounded with the polyving alcohol, the mechanical strength and flexibility of the polyving alcohol hydrogel can be improved through the toughening effect of the elastomer material and the synergistic effect of the inorganic nanoparticles, so that the service life is prolonged, and the requirement of the real application on the mechanical performance can be met; the preparation method of the polyving alcohol composite hydrogel is simple in process, easy to operate and applicable to the mass production.

The invention relates to a method for preparing biocompatible high-strength three-dimensional connected porous polyvinyl alcohol hydrogel, which belongs to the field of biomedical materials. The invention particularly relates to preparation of the porous polyvinyl alcohol hydrogel as an in vivo implantation restoration material and a tissue induction regeneration carrier. The method adopts process methods of high temperature and high pressure dissolving, composite pore forming with a surfactant and soluble solid particles, physical cross-linking forming through circulating refrigeration and dissolving, and cleaning with ultrasonic waves to prepare the three-dimensional porous polyvinyl alcohol hydrogel. The method overcomes the defect that a single pore-forming agent is easy to cause closed and isolated pore spaces, and obtains a network structure with higher porosity, grading connection of the pore spaces and even aperture. The prepared porous polyvinyl alcohol hydrogel has adjustable aperture sizes from 10 to 400 microns and controllable shapes; and the porosity can reach between 50 and 85 percent, thus the porous polyvinyl alcohol hydrogel can be used as a regeneration carrier for inductive tissues of cartilages, blood vessels, skins and the like, is advantageous for the growth of cells, the ingrowth of blood vessel nerves and the transmission of various nutrient substances and has excellent mechanical property, and the modulus of elasticity is between 3.5 and 8.1 MPa.

The invention discloses an irradiation crosslinking chitosan/gelatin/polyvinyl alcohol hydrogel dressing as well as a preparation method and an application thereof. The preparation method comprises the steps that a chitosan, gelatin and polyvinyl alcohol solution is prepared by using ultrapure water serving as a solvent; the solution is stirred and mixed uniformly and then irradiated, and original hydrogel is obtained; the original hydrogel is put into the ultrapure water to be soaked; and the chitosan/gelatin/polyvinyl alcohol hydrogel dressing is prepared. The hydrogel dressing is extensive in raw material source, simple in preparation technology and stable in performance, and has the advantages of inflammation diminishing, wound pain relieving, scar reduction, wound healing promotion, wound seepage absorption, and excellent biocompatibility. The hydrogel dressing is easy to degrade after abandoned, and has a smaller influence on an environment. The hydrogel dressing can be applied to the fields of trauma hemostasis, inflammation diminishing, scald, postoperative wound healing and the like.

The invention discloses polyvinyl alcohol hydrogel and a preparation method thereof and belongs to the field of biological materials. The polyvinyl alcohol hydrogel is prepared by adopting agarose AG as a pore-forming agent, adopting polyvinyl alcohol as a matrix, freezing and thawing. The polyvinyl alcohol hydrogel is prepared from the following components, counted by 100 parts by mass, 15 to 20 parts of the polyvinyl alcohol, 2 to 6 parts of the agarose and the balance of deionized water. The preparation method comprises the following steps: firstly, completely dissolving the polyvinyl alcohol into the deionized water, then adding the agarose and uniformly mixing; carrying out processes such as defoaming, freezing, thawing and eluting on a mixed solution to obtain the polyvinyl alcohol hydrogel with high strength and a porous structure. The preparation method disclosed by the invention is simple; the obtained hydrogel has the advantages of simple formation and stable structure; mechanical properties and the porous structure of the polyvinyl alcohol hydrogel can meet the requirements of natural articular cartilage materials.

The invention belongs to the technical field of macromolecular materials and discloses high-strength lignin/polyvinyl alcohol composite antibacterial aquagel and a preparation method therefor. The composite antibacterial aquagel disclosed by the invention is lignin reinforced PVA aquagel. The high-strength lignin/polyvinyl alcohol composite antibacterial aquagel is obtained specifically through mixing lignin with PVA to prepare gel A, and then, carrying out water-soluble silver salt solution soaking and reducer reduction sequentially. According to the high-strength lignin/polyvinyl alcohol composite antibacterial aquagel and the preparation method therefor, through adding the lignin into polyvinyl alcohol aquagel, a nano micro-phase separating structure is formed through self assembly, and meanwhile, the adsorption to Ag<+> is promoted; and Ag<+> adsorbed to the external surface of the aquagel is reduced by a reducer, and thus, dense nano silver particle clusters are formed on the surface of the aquagel. Due to a tight external structure and a loose internal structure, the aquagel can have ultrahigh mechanical strength and toughness and excellent electric conductivity and antibacterial performance, and the tensile strength reaches up to 13.0MPa; the elongation at break reaches up to 1500%; and the electric conductivity reaches up to 10.126S/m.

The invention discloses a preparation method for rare earth niobate high-temperature ceramics RENbO4 (RE=Y, Nd, Sm, Eu, Gd, Dy, Er and Yb). The adopted raw materials include rare earth oxide and niobium oxide. The method comprises the following steps: weighting the raw materials in proportion; putting the weighted raw materials and absolute ethyl alcohol into a ball-milling tank, mixing, sealing and then putting on a planetary ball mill for milling, and uniformly mixing; adding binder, namely, polyvinyl alcohol hydrogel, into the milled mixture, and then milling for a period of time, and uniformly mixing; drying and screening the mixed powder and then putting into a mold for compacting; pre-sintering; cooling, taking out the sample after pre-sintering, grinding, milling, adding polyvinyl alcohol hydrogel, and then milling, drying and screening; putting the powder after screening in the mold and compacting, and then sintering for the second time. The preparation method has the advantages of high technical purity, low impurity content, low product preparation cost and suitability for bath production. The targeted product is expected to become a novel high temperature-resisting, antioxidant and abrasion-resisting ceramic material.

The invention discloses a preparation method of a high-performance polyvinyl alcohol (PVA) hydrogel artificial cartilage substitute material. The preparation method is characterized in that the characteristics of high strength, excellent wear-resisting self-lubrication property and easy functional modification of a carbon nanomaterial are utilized, functional coupling agents having an active functional group and an excellent self-lubrication property like polyethylene oxide and polysiloxane are used to implement coupling treatment on the surface of the carbon nanomaterial, a PVA/carbon nanomaterial nanocomposite gel is studied and prepared, carbon nanoparticles are excellently dispersed in a PVA matrix, the roles of the functional coupling agent in coupling, increasing capacity, and synergistically enhancing with the carbon nanoparticle, and reducing friction are played; the composite gel is stretched and oriented on the basis to form a molecular orientation structure, the mechanical toughness is further improved, and the service life is prolonged.

The present invention discloses one kind of compound partial femoral head surface prosthesis with very low wear to the cartilage and long lifetime. The compound partial femoral head surface prosthesis includes one pin and one prosthesis member copying the femoral head joint surface. The prosthesis member is made of PVA aquegel, and the pin has its upper part connected to the prosthesis member integrally. The present invention has the advantages of the excellent tribological characteristic of the prosthesis member, low wear to the cartilage, long term biological fixing and long lifetime.

The invention discloses a preparation method of nano-silver-loaded polyvinyl alcohol hydrogel. Sodium borohydride is adopted as a reductant, and the nano-silver-loaded polyvinyl alcoholhydrogel with controllable morphology and particle size is prepared with a cycle freezing and thawing method and an immersion method. The operation is simple, complicated technological equipment is not needed, and polyvinyl alcohol adopted as a dispersion stabilizer can have supporting and protecting effects on nano-silver particles with enhanced electromagnetism. When crystal violet is detected with the nano-silver-loaded polyvinyl alcohol hydrogel, the detection limit of the hydrogel can reach 10-12 orders of magnitude, and the hydrogel is convenient to use and easy to operate.

The invention discloses a sodium alginate-dopamine/polyvinyl alcohol hydrogel, and a preparation method and application thereof. The preparation method comprises the following steps: grafting dopamine(DA) on sodium alginate (SA) through chemical cross-linking to introduce nerve conduction substances, communicate cells and convey chemical substances, so that a wound healing effect is promoted, physical adhesion capability is improved, and biocompatibility of the material is improved; then combination is carried out with medicine-grade polyvinyl alcohol (PVA) which has good biocompatibility, ischeap and is easy to obtain, so that physical performance of hydrogel is improved, and therefore, the hydrogel with relatively high mechanical strength is prepared. The hydrogel provided by the invention has good biocompatibility and excellent physical performance, the reaction raw materials are cheap and are easy to obtain, reaction conditions are mild, and operation steps are simple and convenient. The hydrogel provided by the invention has a wide application prospect in bedsores wound care and biomedicine.

The invention discloses a preparation method of a high-strength and high-adhesion branched starch composite polyacrylamide/ polyvinyl alcohol hydrogel with a strong hydrogen bonding effect, the methodcomprises the following steps: branched starch, polyvinyl alcohol, polymer monomer acrylamide and a photoinitiator are dissolved to obtain a uniform mixed solution, firstly, the uniform mixed solution is initiated under the condition of ultraviolet light, so that the acrylamide is polymerized, micro-crystals are formed in a polyvinyl alcohol network in the freezing and unfreezing process, a multi-hydrogen bond interaction can be formed between molecular chains of the branched starch and molecular chains of the polyacrylamide and molecular chains of the polyvinyl alcohol, and under the doubleactions of multiple hydrogen bonds and the micro-crystals, multi-physical-bond cooperative cross-linking is realized. The preparation process is simple and convenient to operate, and the prepared hydrogel has relatively high mechanical strength and excellent adhesion property on the surface of glass, and can be used as a preferred material of a soft robot.

The present invention is directed to a compression bandage for the treatment of pain and inflammation, comprising a support substrate and an interpenetrating network of PVA disposed within the support substrate. The bandage provides cooling and delivery of therapeutic compounds. The bandage comprises an open cell foam matrix carrying an incorporated PVA hydrogel and optionally at least one additional therapeutic agent.