39 results about "Polyethyleneglycol diacrylate" patented technology

The invention discloses a preparation method of anti-bacterial hydrogel dressing. The method comprises the following steps: 1) dissolving dihydroxy-terminated polyethylene glycol in tetrahydrofuran, adding acryloyl chloride to react at room temperature under the protection of nitrogen, treating the obtained reaction product through filtrating, evaporating, washing and concentrating to obtain polyethyleneglycol diacrylate crosslinking agent; 2) using ZnO nanoparticles containing Ag<+> to prepare 15-30wt% of nanometer water solution, then dissolving natural high molecular material in the nanometer water solution to obtain natural high molecular water solution containing nano-Ag; 3) mixing acrylamide, polyethyleneglycol and natural high molecular water solution containing nano-Ag, placing themixture at room temperature under the irradiation of <60>Co source for crosslinking and obtaining the anti-bacterial hydrogel dressing, the molar ratio of Ag to Zn is 1:4. The anti-bacterial hydrogeldressing prepared by the method is a kind of porous reticular dressing with antibacterial property and hydrating capacity.

The invention discloses gelatin hydrogel, which is of a water molecule filled porous three-network structure, wherein the first network is a cross-linked network between the modified gelatin; the second network is a cross-linked network between polyethylene glycol diacrylate; the third network is a cross-linked network between the modified gelatin and the polyethylene glycol diacrylate. The invention also discloses a preparation method of the gelatin hydrogel. By using an ultraviolet light catalytic crosslinking technology, the modified gelatin is cross-linked with the polyethylene glycol diacrylate; the gelatin hydrogel is obtained through preparation. The gelatin hydrogel provided by the invention has the advantages that the elasticity modulus and the degrading performance of the support frame can be regulated and controlled through changing the modification degree of the modified gelatin and the addition quantity of the polyethylene glycol diacrylate; the structure regulation can be better performed according to the requirements of different tissue engineering support frames; the proper space and the intensity can be provided for the growth of the cells; the ordered space structure is formed.

The invention discloses antioxidant hydrogel for promoting wound healing as well as a preparation method and an application of the antioxidant hydrogel. The hydrogel contains a pattern drug, polydopamine nano particles, polyethyleneglycol diacrylate, a photoinitiator and water, wherein the sum of the polydopamine nano particles and polyethyleneglycol diacrylate in percentage by mass is 10%-23%, and water accounts for 75%-88% in percentage by mass. The hydrogel has the advantages of being good in biocompatibility and free of cytotoxicity; the hydrogel has a good moisturizing function and breathability, cannot result in wound dehydration, and has a good function of absorbing trauma secreta and good oxygen permeation property and controlled drug release capability, so that a hydrophobic drugcan be slowly released, slow release and controlled release effects are realized, blood concentration is kept in a stable and lasting effective range, further, the action time of the drug can be prolonged, and the hydrogel has functions of sufficiently inhibiting wound infection and effectively promoting wound healing, is high in safety and convenient to use and has broad application prospect.

The invention relates to the technical field of the UV (ultraviolet) ink, and in particular relates to a water-based UV plastic screen printing ink and a method for preparing the same. The water-based UV plastic screen printing ink provided by the invention is composed of the following raw materials in parts by weight: 25-40 parts of aliphatic urethane acrylate, 20-30 parts of UV cured acrylic emulsion, 10-20 parts of polyethyleneglycol diacrylate, 10-20 parts of ethylated trimethylolpropane triacrylate, 15-20 parts of pigment powder, 0.5-1 part of organic silicon defoamer, 1-5 parts of organic silicon flatting agent, 5-15 parts of absolute ethyl alcohol, 1-3 parts of photoinitiator, 0.4-2 parts of adhesion promoter and 4-10 parts of water. The water-based UV plastic screen printing ink greatly improves the flexibility of an ink layer and improves the properties of products, and is good in printing adaptability.

The invention relates to the gloss oil technical field and in particular relates to water-based UV (Ultraviolet) tin printing gloss oil and a method for preparing the same. The water-based UV tin printing gloss oil is composed of the following raw materials in parts weight: 30-40 parts of water-based UV photo-curable resin, 8-18 parts of UV cured acrylic emulsion, 12-18 parts of polyethyleneglycol diacrylate, 8-15 parts of ethylated trimethylolpropane triacrylate, 0.5-1 part of organic silicon defoamer, 1-5 parts of organic silicon flatting agent, 5-15 parts of alcohol type auxiliary, 4-8 parts of photoinitiator, 2-6 parts of adhesion promoter and 4-10 parts of water. The method for preparing the water-based UV tin printing gloss oil is capable of optimizing the performance of the gloss oil by employing only two types of water-based UV monomers, so that the types of the UV monomers are simplified, the use amount of the UV monomers is reduced and the residual smell after glazing is lower; and the two types of water-based UV monomers both are low-thrill UV monomers, and thus the gloss oil is low in pollution safer for the ink producers and the users.

The invention provides a method for preparing a photoresponse hydrogel containing azo monomers by utilizing light sources with different wavelengths, belonging to the field of hydrogels. The method comprises the step of: crosslinking acrylic ester and the activated azo monomers by a crosslinker through ultraviolet light or visible light to prepare the photoresponse hydrogels with different properties and release mechanisms, wherein the acrylic esters comprise hydroxy-ethyl acrylate (HEA) or hydroxyethyl methacrylate (HEMA); the structures of the activated azo monomers are shown as formula (I) and formula (II), wherein R1 and R2 are H, COOH and SO3H; and the crosslinker is N, N-methylene-bisacrylamide and water-soluble bifunctional acrylic esters and comprises polyethyleneglycol diacrylate (200, 400, 600, 800, 1000), wherein the R1 and the R2 are the H, the COOH and the SO3H. The invention has moderate condition and simple step and can be used for biomedicine aspects, i.e. drug controlled-release materials, tissue engineering, and the like.

The invention belongs to the field of new electric power materials and discloses novel conductive plastic. The novel conductive plastic is prepared from chlorinated butadiene, polyethylene wax, polyethyleneglycol diacrylate, epoxy resin, tristearin, conductive carbon black, graphite fibers, glass fibers, barium stearate, magnesium hydroxide, barium stearate, powdered steatile, lithium-based bentonite, titanium oxide, zinc oxide and silicon carbide. The novel conductive plastic keeps good conductive performances of plastic and has good tensile strength.

The invention relates to a temperature-sensitive nano aquagel, and a preparation method and application thereof. The nano aquagel is prepared by copolymerizing polyethyleneglycol diacrylate and a methacrylic acid monomer or acrylic acid monomer, the dynamic particle size is 100-500nm, and the minimum critical solution temperature under stomach juice conditions is 15-75 DEG C. The nano aquagel is prepared by polymerizing the acrylic acid or methacrylic acid monomer, the polyethyleneglycol diacrylate and an initiator in a solvent by a precipitation polymerization process. The polyethyleneglycol diacrylate-methacrylic acid copolymer nano aquagel is used as a drug carrier for controlling drug release under human gastrointestinal environmental conditions.

The invention discloses an adhesive for a motion floor. The adhesive is prepared from 7-11 parts by weight of rosin, 6-10 parts by weight of ES-allethrolone, 7-11 parts by weight of epoxy resin, 5-9 parts by weight of an acrylate monomer, 5-7 parts by weight of an epoxy resin room-temperature curing agent, 6-8 parts by weight of polyethyleneglycol diacrylate, 2-7 parts by weight of benzophenone, 1-3 parts by weight of shell-core rubber powder, 2-6 parts by weight of a curing promoter, 8-12 parts by weight of polyether polyol, 2-8 parts by weight of a plasticizer, 4-11 parts by weight of trichloropropylphosphate, 3-6 parts by weight of sodium hydroxide and 3-10 parts by weight of borax. The adhesive for a motion floor can improve floor water resistance, resist ultraviolet ray and improve a floor service life.

The invention provides photo-curing material.The photo-curing material comprises, by weight percentage, 55-80% of matrix resin, 1-5% of photo-initiator, 10-20% of reactive diluent and 9-20% of auxiliaries, wherein the matrix resin comprises polyethylene glycol diacrylate and dicyclohexylmethylmethane-category alicyclic diisocyanate.The invention further provides a preparation method of the photo-curing material.The preparation method includes: adding raw materials into a reactor, stirring for dissolving, then stirring at constant temperature for 6-8 hours, cooling, and filtering, wherein the stirring temperature is 35-45 DEG C, and preferably the stirring temperature is 38-42 DEG C.The invention also provides zirconia printing material prepared by using the photo-curing material, and the zirconia printing material comprises, by weight percentage, 90-95% of zirconia powder and 5-10% of the photo-curing material.

The invention discloses a double-negative acoustic metamaterial based on Mie resonance and used for transcranial ultrasonic imaging. The double-negative acoustic metamaterial comprises an ultrasonic coupling agent as a matrix and a scatterer dispersed in the matrix and used for generating Mie resonance, wherein the scatterer is porous polyethylene glycol diacrylate hydrogel microspheres; and the volume fraction of the porous polyethylene glycol diacrylate hydrogel microspheres in the matrix is 15-25%. The double-negative type acoustic metamaterial provided by the invention can effectively eliminate the dissipation and distortion effects of the skull on sound waves, so that the double-negative type acoustic metamaterial is expected to realize transcranial ultrasonic imaging without depending on the natural existence of the skull or an artificially manufactured acoustic window.

The invention discloses a special UV (Ultraviolet) curing antibacterial coating for plastics. The special UV curing antibacterial coating for plastics is characterized by being prepared from the following active ingredients in parts by weight: 50-55 parts of epoxy acrylate, 9-12 parts of polyethyleneglycol diacrylate, 7-10 parts of hydroxypropyl acrylate, 4-6 parts of glycidyl acrylate, 3-4 parts of 2-methyl-2-(4-morpholinyl)-1-[4-(methylthio)phenyl]-1-acetone, 12-15 parts of methacrylate laurate, 9-12 parts of ethyl acetate, 1-2 parts of polydimethyl siloxane, 1-2 parts of silane coupling agent KH550, 6-8 parts of nanometer wollastonite, 3-4 parts of lithopone, 1-2 parts of IPBC (iodopropynyl butylcarbamate), and 4-5 parts of auxiliaries. Due to added IPBC antibacterial substances, the special UV curing antibacterial coating has the effects of oxidation resistance and mildew repression; due to the auxiliaries, the coating is good in leveling property, good in flexibility, hardness, adhesion force, wear resistance and scratch resistance, energy-saving and environment-friendly, and high in production efficiency and application to plastic surfaces.

The invention provides a collagen-based composite cornea substitute with bioactivity and a preparation method thereof. The composite cornea substitute is prepared by the following steps: taking collagen and 3-(methacrylamide)propyl-dimethyl(3-sulfopropyl)amide (MPDSAH) as raw materials and water as a solvent, crosslinking the collagen with zero-length cross linker carbodiimide (EDC); taking Irgacure 2959 as a photo initiator and polyethyleneglycol diacrylate (PEGDA) as a crosslinking agent to perform initiated polymerization and crosslinking for the MPDSAH; and after even mixing, injecting a die with the mixture for cure forming. After freeze drying, the composite cornea constitute has a three-dimensional porous structure, can adsorb a large amount of cornea cell growth factors, can be stored for a long time, and can recover the primary shape and performance like before freeze drying after water absorption and expansion. The prepared composite cornea substitute has good histocompatibility, can induce and promote the cornea regeneration, and can be biodegraded along with the cornea regeneration, and the introduction of the growth factors can promote the enrichment of self growth factors and reduce the occurrence of postoperative complications.

The invention provides a self-polishing antifouling paint which is prepared from the following raw materials in parts by weight: 228-250 parts of methyl methacrylate, 16-20 parts of polyethyleneglycol diacrylate, 132-140 parts of tributyltin acrylate, 24-28 parts of polyethyleneglycol, 190-210 parts of cuprous oxide, 120-150 parts of zinc oxide, 110-125 parts of titanium white and 150-180 parts of xylene. The manufacturing method comprises the following steps: heating to copolymerize the methyl methacrylate, polyethyleneglycol diacrylate, tributyltin acrylate and polyethyleneglycol, dissolving the obtained copolymer in the xylene, adding the other powders, grinding and screening to obtain the self-polishing antifouling paint. When the paint is applied to the ship bottom, the obtained coated film has favorable self-polishing performance in water.

The invention discloses a high-strength conductive hydrogel based on polyethyleneglycol diacrylate crosslinking and a preparation method thereof. According to the invention, 2-vinyl-4,6-diamino-1,3,5-triazine is taken as a monomer, polyethyleneglycol diacrylate is taken as a cross-linking agent, poly(3,4-ethylenedioxy group thiophene)-poly (styrene sulfoacid) is taken as a blending component, a free radical polymerization is carried out on a monomer initiated through an initiator and carbon-carbon double bonds on the cross-linking agent to form a hydrogel network having physical crosslinking and chemical crosslinking, and the poly(3,4-ethylenedioxy group thiophene)-poly (styrene sulfoacid) is doped in a gel network structure. The hydrogel has the advantages of simple process, strong stretching and compression performance, good conductivity, and good biocompatibility.

The invention relates to a preparation method for a salt-tolerant thickening agent. The method comprises the following steps: polyethyleneglycol diacrylate having certain hydrophilicity is used as a crosslinking agent, a functional monomer having a hydrophobic long chain and a water-soluble group is selected, the selected functional monomer and an acrylic monomer are subjected to copolymerization,and therefore the salt-tolerant thickening agent is prepared. According to the method provided by the invention, the thickening agent obtained by the method has excellent thickening performance and electrolyte resistance.

The invention discloses an electronic product screen protection film patch, which is prepared from the following raw materials in parts by weight: 20 to 40 parts of polyvinyl chloride, 12 to 25 parts of polyvinyl alcohol, 5 to 15 parts of radiation protection slurry, 3 to 10 parts of polyether polyol, 2 to 10 parts of oleic acid ester, 3 to 7 parts of polyethyleneglycol diacrylate, 3 to 6 parts of styrene-butadiene rubber, 2 to 6 parts of fluorinated ethylene propylene, 2 to 9 parts of silane coupling agents, 1.5 to 3.5 parts of solidification liquid and 1 to 4 parts of dispersoids. The invention provides the electronic product screen protection film patch and a preparation method. The problem of great forming difficulty of the protection film patch in the prior art is solved. In addition, the qualification rate of an electronic product is improved; the production and manufacturing cost is greatly reduced. The electronic product screen protection film patch prepared by the preparation method has the advantages of scratching mark resistance and anti-fingerprint effects.

The invention discloses a photo-initiated polyethylene glycol-based hydrogel dressing. The dressing is prepared by taking a polyethylene glycol diacrylate solution, a bioactive molecule solution and aphotoinitiator as raw materials, mixing the polyethylene glycol diacrylate solution with the photoinitiator, then mixing obtained mixture with the bioactive molecule solution, and performing irradiating with an ultraviolet lamp tube. The weight ratio of the polyethylene glycol diacrylate solution to the bioactive molecule solution is (4-7):(6-3), and the weight ratio of the polyethylene glycol diacrylate solution to the photoinitiator is 100:(0.05-0.2). The photo-initiated polyethylene glycol-based hydrogel dressing has certain mechanical properties and water absorption swelling properties, is suitable for wound surface protection and infection treatment, and can enhance cell adhesion and promote cell proliferation so as to realize application of the dressing in the aspects of beauty treatment, wound healing and tissue engineering.

The invention relates to a preparation method of a corn stalk fertilizer. The method comprises the following steps that corn stalk powder is prepared; a potassium peroxodisulfate with the concentration being 36 wt%, a sodium sulfite solution with the concentration being 52 wt%, an acrylic acid solution with the neutralization being 50-70%, acrylamide, polyethyleneglycol diacrylate, urea and the corn stalk powder are sequentially added into a reactor on the condition of a cold bath and stirring, then, water is added to reach the needed volume, and a monomer phase is obtained; span-60 is added into the reactor, the monomer phase obtained in the third step is slowly added on the condition that nitrogen is introduced, then k2SO3 is added for standing for 20 min, the rotating speed is increased to be subjected to a reaction for 3 h, after the reaction is finished, suction filtration is performed to obtain bead form gel, and vacuum drying is performed at the temperature of 42-48 DEG C for 3-6 h to obtain the powdered corn stalk fertilizer. According to the method, the corn stalk based high-water-absorption fertilizer is prepared at normal temperature, the reaction conditions are mild, energy conservation and environmental protection are achieved at the room temperature, the obtained fertilizer is good in water absorption and water retention, and high in slow-release effect, and the preparation technology is simple and low in price.

The invention discloses a diphtheria toxin loaded microneedle used for scar repair, and a preparation method of the diphtheria toxin loaded microneedle. The microneedle is a hydrogel microneedle which loads diphtheria toxins. The microneedle is prepared by curing a hydrogel precursor solution mixed with the diphtheria toxin in a microneedle template. The hydrogel precursor is selected from one or more of chitosan, gelatin, silk fibroin, hyaluronic acid, sodium alginate, polyvinyl alcohol, polyethylene glycol, carboxymethyl cellulose, methacrylate gelatin, polyethylene glycol diacrylate, polylactic acid, polylactic acid-glycolic acid copolymers, polyvinylpyrrolidone and polydopamine. The diphtheria toxin loaded microneedle has the advantages of being high in permeability, simple in operation and the like, and can reduce administration frequency.

The invention relates to a preparation method for a salt-tolerant thickening agent. The method comprises the following steps: polyethyleneglycol diacrylate having certain hydrophilicity is used as a crosslinking agent, a functional monomer having a hydrophobic long chain and a water-soluble group is selected, the selected functional monomer and an acrylic monomer are subjected to copolymerization,and therefore the salt-tolerant thickening agent is prepared. According to the method provided by the invention, the thickening agent obtained by the method has excellent thickening performance and electrolyte resistance.

The invention discloses a concrete addictive and a preparation method thereof. The addictive comprises the following components in parts by weight: 100 parts of methacrylic acid, 33-50 parts of sodium hydroxide, 0.04-0.06 part of hydroxyethyl cellulose, 0.04-0.06 part of potassium sulphate and 0.01-0.03 part of polyethyleneglycol diacrylate. The concrete addictive provided by the invention has no corrosion action to concrete and steel reinforcing bars, favorable stability and no demixed phenomenon; in addition, the concrete addictive can be used for preventing water from evaporating, thereby water in the concrete can be utilized to the maximum extent for finishing the hydration, the surface crazing caused by temperature change is reduced, further the effect for beautifying the surface is achieved, the curing period can be shortened simultaneously, water and labor are saved and the engineering cost is reduced.

The invention discloses a polymer solid electrolyte and a preparation method and application thereof. The preparation method of the polymer solid electrolyte comprises the following steps: dissolving an alkali metal salt in a polymer monomer, sequentially adding a cross-linking agent, a photoinitiator and a polar solvent, and uniformly mixing to obtain a pre-polymerization system; and uniformly coating the prepolymerization system on a mold, and curing by ultraviolet or visible light irradiation to obtain the polymer solid electrolyte, wherein the polymer monomer is polyethylene glycol diacrylate and / or polypropylene glycol diacrylate; the cross-linking agent is one or more of trimethylolpropane tri (3-mercaptopropionate), trimethylolpropane triacrylate and pentaerythritol triacrylate; the polar solvent is ionic liquid and / or butanedinitrile. According to the preparation method, the compatibility between the polymer monomer and the strong polar component in the prepolymerization system is remarkably improved, and the polymer solid electrolyte obtained after photocuring has high transparency.

The invention provides a temporary plugging agent for horizontal well water control, and a preparation method and application thereof. The temporary plugging agent for horizontal well water control comprises the following raw materials in parts by weight: 4-15 parts of acrylamide, 0.5-3 parts of polypropylene fiber, 1.5-4 parts of reinforcer, 0.5-1.0 part of composite crosslinking agent, 0.1-0.2 part of initiator and the balance of water, totaling 100 parts. The composite crosslinking agent is a mixture composed of polyethyleneglycol diacrylate and N,N-methylene-bis acrylamide in a mass ratio of 10:(1-4). The preparation method of the temporary plugging agent comprises the following steps: sequentially adding the acrylamide, polypropylene fiber, reinforcer and composite crosslinking agent into water, stirring uniformly, adding the initiator, and standing to react for 1-3 hours, thereby obtaining the temporary plugging agent. The invention also provides application of the temporary plugging agent in horizontal well water control. The temporary plugging agent provided by the invention has the characteristics of high gelling viscosity, controllable degradation time, thorough degradation and the like, can plug the high-permeability zone and implement adjustable degradation time, and can lower the damage to the reservoir.

The invention discloses a mixed photonic crystal composite material based on folic acid modification and application. The mixed photonic crystal composite material is prepared from a mixed photonic crystal carrier and folic acid loaded on the carrier, wherein the mixed photonic crystal is prepared from polyethyleneglycol diacrylate inverse opal skeleton and methacrylate gelatin and magnetic nanoparticles with which skeleton pores are filled. The mixed photonic crystal composite material is applied to the detection for myeloid leukemia drug-resistance cells. The remarkable advantage of the mixed photonic crystal composite material is that the composite material is of a nano ordered structure, the specific surface area is large, the mechanical strength is high, and the stability is strong, and the composite material has the excellent biological compatibility and the magnetic responsiveness, and is easy to control. The composite material is applied to the detection for the drug-resistancecells, the myeloid leukemia drug-resistance cells can be specifically, sensitively, simply and effectively captured, and drug-resistance cell strains with good biological activity are guaranteed, andthe myeloid leukemia drug-resistance cells can be effectively enriched and separated after being captured only if a magnetic field is applied.

The invention provides photo-curing material.The photo-curing material comprises, by weight percentage, 55-80% of matrix resin, 1-5% of photo-initiator, 10-20% of reactive diluent and 9-20% of auxiliaries, wherein the matrix resin comprises polyethylene glycol diacrylate and dicyclohexylmethylmethane-category alicyclic diisocyanate.The invention further provides a preparation method of the photo-curing material.The preparation method includes: adding raw materials into a reactor, stirring for dissolving, then stirring at constant temperature for 6-8 hours, cooling, and filtering, wherein the stirring temperature is 35-45 DEG C, and preferably the stirring temperature is 38-42 DEG C.The invention also provides zirconia printing material prepared by using the photo-curing material, and the zirconia printing material comprises, by weight percentage, 90-95% of zirconia powder and 5-10% of the photo-curing material.

The invention discloses hydrogel of poly-beta amino ester loaded with active substances as well as a preparation method and application of the hydrogel. A Michael addition reaction is carried out on polyethyleneglycol diacrylate and propargyl hydrazide to obtain poly-beta amino ester containing propiolyl; and a coupling reaction is carried out on a bioactive substance containing double bonds or sulfydryl, the poly-beta amino ester and PEG of multi-arm sulfydryl or inositol hexa-mercaptopropionate to obtain the hydrogel of the poly-beta amino ester loaded with the active substance. The hydrogel disclosed by the invention is good in biocompatibility and stable in chemical property, and can be used as a neurotrophic factor carrier for treating nerve injury.

The invention discloses a preparation method of anti-bacterial hydrogel dressing. The method comprises the following steps: 1) dissolving dihydroxy-terminated polyethylene glycol in tetrahydrofuran, adding acryloyl chloride to react at room temperature under the protection of nitrogen, treating the obtained reaction product through filtrating, evaporating, washing and concentrating to obtain polyethyleneglycol diacrylate crosslinking agent; 2) using ZnO nanoparticles containing Ag<+> to prepare 15-30wt% of nanometer water solution, then dissolving natural high molecular material in the nanometer water solution to obtain natural high molecular water solution containing nano-Ag; 3) mixing acrylamide, polyethyleneglycol and natural high molecular water solution containing nano-Ag, placing the mixture at room temperature under the irradiation of <60>Co source for crosslinking and obtaining the anti-bacterial hydrogel dressing, the molar ratio of Ag to Zn is 1:4. The anti-bacterial hydrogel dressing prepared by the method is a kind of porous reticular dressing with antibacterial property and hydrating capacity.

The invention discloses a double-negative acoustic metamaterial with enhanced dipole resonance. The double-negative acoustic metamaterial with enhanced dipole resonance comprises an ultrasonic coupling agent serving as a base body and a scatterer dispersed in the base body and used for generating Mie resonance; the scatterer is a porous polyethylene glycol diacrylate hydrogel microsphere PEGDA added with high-density nanoparticles. The invention also discloses an application of the double-negative acoustic metamaterial in craniocerebral ultrasonic imaging and high-intensity focused ultrasound therapy. The double-negative acoustic metamaterial provided by the invention can realize strong monopole resonance and dipole resonance in a relatively wide frequency range of 1.08-1.32 MHz, so that the negative equivalent mass density and the negative equivalent elastic modulus are obtained at the same time, and the double-negative acoustic metamaterial has a wide application prospect in the medical fields of craniocerebral ultrasonic imaging, high-intensity focused ultrasound therapy and the like.