A temperature sensitive nano hydrogel and its preparation method and application

A nano-hydrogel, sensitive technology, applied in pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve the problems of difficult to control product purity, time-consuming purification process, poor biocompatibility, etc. Short response time, effect of reducing phase transition temperature

Inactive Publication Date: 2017-04-12
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its weak point is: one, in order to obtain the hydrogel of nanoscale, this method must add tensio-active agent to stabilize required particle diameter in the preparation process
Since the surfactant is difficult to remove, this not only makes the purification process of the product more time-consuming, but also the purity of the product is not easy to control
2. Using polyisopropylacrylamide as the matrix, the biocompatibility is poor

Method used

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  • A temperature sensitive nano hydrogel and its preparation method and application
  • A temperature sensitive nano hydrogel and its preparation method and application
  • A temperature sensitive nano hydrogel and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Methacrylic acid (0.105 mmol), polyethylene glycol diacrylate 575 (0.158 mmol), APS (10 wt% aqueous solution, 30 μL) and deionized water (50 mL) were added to a vial with a capacity of 100 ml. Nitrogen was purged for 10 min to remove free dissolved oxygen, then the vial was quickly sealed. Polymerization started at 70°C and continued for 4h. After cooling to room temperature, 400 μL (about 0.8% v / v) of a pH 1.0 hydrochloric acid solution in which 2M sodium chloride was dissolved was added to the polymer solution. The product was collected by centrifugation (10000 rpm). The resulting polymer hydrogel was redispersed in water and dialyzed at room temperature for 72 hours. After 24 hours of lyophilization and weighing, the yield of the obtained polymer hydrogel was 15.9%. The scanning electron microscope picture of product polyethylene glycol diacrylate-methacrylic acid copolymer nano hydrogel figure 1 , showing the morphology and particle size distribution of nano-hyd...

Embodiment 2

[0044] Methacrylic acid (0.211 mmol), polyethylene glycol diacrylate 575 (0.143 mmol), APS (10 wt% aqueous solution, 30 μl) and deionized water (50 mL) were added to a vial with a capacity of 100 ml. Nitrogen was purged for 10 min to remove free dissolved oxygen, then the vial was quickly sealed. Polymerization started at 70°C and continued for 4h. After cooling to room temperature, 400 μL of a hydrochloric acid solution at pH 1.0 in which 2M sodium chloride was dissolved was added to the polymer solution. The product was collected by centrifugation (10000 rpm). The resulting polymer hydrogel was redispersed in water and dialyzed at room temperature for 72 hours. After 24 hours of lyophilization and weighing, the yield of the obtained polymer hydrogel was 38.5%. The scanning electron microscope picture of product polyethylene glycol diacrylate-methacrylic acid copolymer nano hydrogel figure 2 , showing the morphology and particle size distribution of nano-hydrogel materia...

Embodiment 3

[0047] Methacrylic acid (0.435 mmol), polyethylene glycol diacrylate 575 (0.109 mmol), APS (10 wt% aqueous solution, 30 μl) and deionized water (50 mL) were added to a vial with a capacity of 100 ml. Nitrogen was purged for 10 min to remove free dissolved oxygen, then the vial was quickly sealed. Polymerization started at 70°C and continued for 4h. After cooling to room temperature, 350 μL of a pH 1.0 hydrochloric acid solution in which 2M sodium chloride was dissolved was added to the polymer solution. The product was collected by centrifugation (10000 rpm). The resulting polymer hydrogel was redispersed in water and dialyzed at room temperature for 72 hours. After 24 hours of lyophilization and weighing, the yield of the obtained polymer hydrogel was 50%. The dynamic particle size of the obtained copolymer nano hydrogel is 207nm. The scanning electron microscope picture of product polyethylene glycol diacrylate-methacrylic acid copolymer nano hydrogel image 3 , showing...

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Abstract

The invention relates to a temperature-sensitive nano aquagel, and a preparation method and application thereof. The nano aquagel is prepared by copolymerizing polyethyleneglycol diacrylate and a methacrylic acid monomer or acrylic acid monomer, the dynamic particle size is 100-500nm, and the minimum critical solution temperature under stomach juice conditions is 15-75 DEG C. The nano aquagel is prepared by polymerizing the acrylic acid or methacrylic acid monomer, the polyethyleneglycol diacrylate and an initiator in a solvent by a precipitation polymerization process. The polyethyleneglycol diacrylate-methacrylic acid copolymer nano aquagel is used as a drug carrier for controlling drug release under human gastrointestinal environmental conditions.

Description

technical field [0001] The invention relates to a temperature-sensitive polyethylene glycol diacrylate-methacrylic acid copolymer nano hydrogel, a preparation method thereof and its application as a drug carrier, belonging to the technical field of polymer materials. Background technique [0002] Temperature-sensitive hydrogels are a class of smart hydrogels that can respond to temperature changes. As the ambient temperature changes, the physicochemical properties (such as volume, water content, refractive index, and permeability, etc.) of temperature-sensitive hydrogels will change considerably. At present, temperature-sensitive hydrogels have been widely used in many aspects such as controlled drug release, gene transfer, enzyme immobilization, and immunoprecipitation. [0003] Common temperature-sensitive polymers include polyisopropylacrylamide (PNIPAM), poly(hydroxyethyl methacrylate) (PHEMA), polyvinylpyrrolidone (PVP), and hydroxypropyl cellulose (HPC), among others....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F290/06C08F220/06A61K47/32
Inventor 陈志勇曹红岩王雪玲尚豹
Owner UNIV OF JINAN
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