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Diphtheria toxin loaded microneedle used for scar repair, and preparation method of diphtheria toxin loaded microneedle

A diphtheria toxin and microneedle technology, which is applied in the field of diphtheria toxin-loaded microneedles and its preparation, can solve the problems of poor tissue permeability, difficulty penetrating scars, and difficulty maintaining effective drug concentration in scars, so as to achieve enhanced permeability and needle tip Penetrating and permeable effect

Pending Publication Date: 2021-09-07
NANJING DRUM TOWER HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, diphtheria toxin lacks an external dosage form, and the tissue permeability of the direct application of the drug is poor, it is difficult to penetrate the scar, and it is difficult to maintain an effective drug concentration at the scar site

Method used

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  • Diphtheria toxin loaded microneedle used for scar repair, and preparation method of diphtheria toxin loaded microneedle
  • Diphtheria toxin loaded microneedle used for scar repair, and preparation method of diphtheria toxin loaded microneedle
  • Diphtheria toxin loaded microneedle used for scar repair, and preparation method of diphtheria toxin loaded microneedle

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Embodiment 1

[0023] This embodiment provides a diphtheria toxin-loaded microneedle for scar repair and a preparation method thereof.

[0024] Such as figure 1 As shown in middle b, the microneedle is a hydrogel microneedle loaded with diphtheria toxin, which is prepared by curing a hydrogel precursor solution mixed with diphtheria toxin. The specific preparation method includes the following steps:

[0025] Step 1. Mix the diphtheria toxin powder with 600 μL polyethylene glycol diacrylate solution (60% v / v, the solution is ultrapure water), and the mixing concentration of diphtheria toxin in the hydrogel precursor solution is 50 ng / mL .

[0026] A photoinitiator 2-hydroxy-2-methylphenylacetone (HMPP) (1% v / v) was also mixed in the hydrogel precursor solution, ie polyethylene glycol diacrylate solution.

[0027] Step 2. Make a microneedle template by laser etching the silica gel substrate; drop the hydrogel precursor solution mixed with diphtheria toxin obtained in step 1 into the microne...

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Abstract

The invention discloses a diphtheria toxin loaded microneedle used for scar repair, and a preparation method of the diphtheria toxin loaded microneedle. The microneedle is a hydrogel microneedle which loads diphtheria toxins. The microneedle is prepared by curing a hydrogel precursor solution mixed with the diphtheria toxin in a microneedle template. The hydrogel precursor is selected from one or more of chitosan, gelatin, silk fibroin, hyaluronic acid, sodium alginate, polyvinyl alcohol, polyethylene glycol, carboxymethyl cellulose, methacrylate gelatin, polyethylene glycol diacrylate, polylactic acid, polylactic acid-glycolic acid copolymers, polyvinylpyrrolidone and polydopamine. The diphtheria toxin loaded microneedle has the advantages of being high in permeability, simple in operation and the like, and can reduce administration frequency.

Description

technical field [0001] The invention belongs to the field of biomedical materials and relates to a microneedle, in particular to a diphtheria toxin-loaded microneedle for scar repair and a preparation method thereof. Background technique [0002] Scar is an inevitable product in the process of wound healing in the human body, which can be caused by various reasons such as trauma, cuts, infection, burns, and surgery. Divided into hypertrophic scars, atrophic scars and keloids three categories. Scar growth will cause various complications such as dysfunction and appearance destruction, which will bring great physical and mental burden to patients. Current treatment methods mainly include chemotherapy, radiotherapy, laser therapy, surgical resection, etc., which are prone to recurrence and inconvenient to operate. Therefore, there is a need for a novel treatment method that is simple to operate, has few side effects, and is not easy to relapse. [0003] Engrailed-1 (En1) pos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/16A61K9/00A61P17/02
CPCA61K38/164A61K9/0021A61K47/14A61P17/02
Inventor 赵远锦陈国璞王月桐商珞然张大淦
Owner NANJING DRUM TOWER HOSPITAL
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