A hybrid photonic crystal composite material based on folic acid modification and its application
A technology of photonic crystals and composite materials, applied in animal cells, vertebrate cells, tumor/cancer cells, etc., can solve the problems of large damage to CTCs and limited capture efficiency of CTCs, and achieve high mechanical strength, superior magnetic response, and easy manipulation Effect
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Embodiment 1
[0038] Preparation of silica colloidal microspheres (SCCBs):
[0039] (1) SiO 2 After the nanoparticles were sonicated for 1 h, they were centrifuged at 8000 rpm for 10 min, and ultrapure water was added after removing the supernatant, and the above steps were repeated 20 times.
[0040] (2) SiO after the above cleaning 2 The nanoparticles were formulated into an emulsion with a mass fraction of 20%, and ultrasonicated for 30 minutes.
[0041] (3) Add an appropriate amount of n-hexadecane (containing 1% Hypermer2296 surfactant) to the collector and the oil phase injector, preheat at 45°C, adjust the oil phase speed to 2ml / h and the water phase speed to 1ml / h; wherein, Liquid volume of n-hexadecane: the distance from the bottom of the collector is about 0.3cm. If the amount is large, the balls will easily float and merge with each other. If the amount is small, the balls will not be in a suspended state and cause collapse; The amount of alkane is more than three times the to...
Embodiment 2
[0062] Preparation of silica colloidal microspheres (SCCBs):
[0063] Step is identical with embodiment 1.
[0064] Preparation of hybrid photonic crystal composites based on folic acid modification:
[0065](1) Preparation of pregel A: polyethylene glycol diacrylate 70%, photoinitiator 2% and water 28%; preparation of pregel B: methacrylate gelatin (GelMA), iron concentration is 4mg / ml Magnetic nano particle suspension, photoinitiator and water, wherein, the volume ratio of magnetic nano particle suspension, water and photoinitiator is 2:60:1, and magnetic nano particle is carboxylated ferroferric oxide magnetic nano particle.
[0066] (2) Preparation of inverse opal framework of polyethylene glycol diacrylate (PEGDA): Wrap the transparent plastic centrifuge tube containing SCCBs with tinfoil, add pre-gel A dropwise until it is completely covered, shake properly, and let stand at room temperature 45min, so that the pregel A is fully immersed in the pores of SCCBs; then use ...
Embodiment 3
[0070] Preparation of silica colloidal microspheres (SCCBs):
[0071] Step is identical with embodiment 1.
[0072] Preparation of hybrid photonic crystal composites based on folic acid modification:
[0073] (1) Preparation of pre-gel A: polyethylene glycol diacrylate 90%, photoinitiator 1% and water 9%; preparation of pre-gel B: methacrylate gelatin (GelMA), iron concentration of 4mg / ml Magnetic nano particle suspension, photoinitiator and water, wherein, the volume ratio of magnetic nano particle suspension, water and photoinitiator is 3:80:1.
[0074] (2) Preparation of inverse opal framework of polyethylene glycol diacrylate (PEGDA): Wrap the transparent plastic centrifuge tube containing SCCBs with tinfoil, add pre-gel A dropwise until it is completely covered, shake properly, and let stand at room temperature 30min, so that the pregel A is fully immersed in the pores of SCCBs; then use ultraviolet light to polymerize for 40s, during the polymerization process, the cen...
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