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Preparation method of anti-bacterial hydrogel dressing

A hydrogel and aqueous solution technology, applied in medical science, absorbent pads, bandages, etc., can solve the problems of good adhesion and no function, and achieve good adhesion, high biocompatibility, and strong hydration performance Effect

Inactive Publication Date: 2010-03-10
绍兴锐创生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] With the development of material science, synthetic polymer materials such as polyacrylamide, polyurethane, and polyvinyl alcohol are widely used in new skin dressings; however, these materials have no other advantages except for good adhesion, isolation of bacteria, and keeping the wound surface moist. Function

Method used

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  • Preparation method of anti-bacterial hydrogel dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1, a kind of preparation method of antibacterial hydrogel dressing, carries out following steps successively:

[0020] 1) Dissolve 50g of double-terminated hydroxyl polyethylene glycol (molecular weight: 2000) after azeotropic water removal with toluene in 200ml of dry tetrahydrofuran, slowly add 25ml of acryloyl chloride dropwise (15 drops / min) under ice bath, After the drop, the ice bath was removed, and the reaction was carried out at room temperature for 8 h under the protection of nitrogen. The resulting reactant was filtered to remove solids to obtain a clear liquid; the clear liquid was evaporated to dryness at 60° C. to obtain a crude product. The crude product was washed three times with saturated sodium chloride solution (200ml×3), then dissolved in 100ml of dichloromethane, and placed in a nitrogen blower (Hangzhou Aosheng Instrument Co., Ltd.) to concentrate the organic phase to reduce the volume of the solution to the original 40% of the volume;...

Embodiment 2

[0023] Embodiment 2, a kind of preparation method of antibacterial hydrogel dressing, the collagen in embodiment 1 step 2) is changed into dextran; Obtain the aqueous solution of dextran containing nano-Ag; The embodiment 1 step 3) in The collagen aqueous solution was changed to dextran aqueous solution, and the irradiation dose was changed to 40KGy; the rest were the same as in Example 1.

[0024] The antibacterial hydrogel dressing with a thickness of 0.5mm and a solid content of 25.0% was obtained by polymerizing in a mold.

Embodiment 3

[0025] Embodiment 3, a kind of preparation method of antibacterial hydrogel dressing, will implement the collagen in 1 step 2) into hyaluronic acid; Obtain the hyaluronic acid aqueous solution containing nanometer Ag; The collagen in embodiment 1 step 3) is changed into hyaluronic acid; The aqueous solution was changed to hyaluronic acid aqueous solution, and the irradiation dose was changed to 80KGy; the rest were the same as in Example 1.

[0026] The antibacterial hydrogel dressing with a thickness of 0.5 mm and a solid content of 33.8% was obtained by polymerizing in a mold.

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Abstract

The invention discloses a preparation method of anti-bacterial hydrogel dressing. The method comprises the following steps: 1) dissolving dihydroxy-terminated polyethylene glycol in tetrahydrofuran, adding acryloyl chloride to react at room temperature under the protection of nitrogen, treating the obtained reaction product through filtrating, evaporating, washing and concentrating to obtain polyethyleneglycol diacrylate crosslinking agent; 2) using ZnO nanoparticles containing Ag<+> to prepare 15-30wt% of nanometer water solution, then dissolving natural high molecular material in the nanometer water solution to obtain natural high molecular water solution containing nano-Ag; 3) mixing acrylamide, polyethyleneglycol and natural high molecular water solution containing nano-Ag, placing themixture at room temperature under the irradiation of <60>Co source for crosslinking and obtaining the anti-bacterial hydrogel dressing, the molar ratio of Ag to Zn is 1:4. The anti-bacterial hydrogeldressing prepared by the method is a kind of porous reticular dressing with antibacterial property and hydrating capacity.

Description

technical field [0001] The invention belongs to the technical field of manufacturing medical wound repair materials, and in particular relates to a method for preparing a porous mesh dressing with antibacterial performance and hydration performance, which is formed by cross-linking synthetic macromolecules and natural macromolecules by irradiation technology. Background technique [0002] The skin is the largest organ of the human body and a natural barrier between the human body and the outside world; however, the large area exposed to the outside world makes the skin vulnerable to external injuries such as burns and mechanical injuries. my country has a large population base, and there are nearly one million severe burn patients every year. Not only that, but also large-area skin ulcers caused by complications of many chronic diseases such as diabetes, phlebitis, and bedsores are becoming more and more common in my country. Due to the insufficient regeneration ability of th...

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/28A61L15/46A61L15/62A61L15/42
Inventor 余志扬宋伟杰仇建峰
Owner 绍兴锐创生物科技有限公司
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