Preparation method of anti-bacterial hydrogel dressing

A hydrogel and aqueous solution technology, applied in the fields of medical science, absorbent pads, bandages, etc., can solve the problems of good adhesion and no function, and achieve good adhesion, high biocompatibility, and strong hydration performance. Effect

Inactive Publication Date: 2012-09-19
绍兴锐创生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] With the development of material science, synthetic polymer materials such as polyacrylamide, polyurethane, and polyvinyl alcohol are widely used in new skin dressings; however, these materials have no other advantages except for good adhesion, isolation of bacteria, and keeping the wound surface moist. Function

Method used

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  • Preparation method of anti-bacterial hydrogel dressing
  • Preparation method of anti-bacterial hydrogel dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1, a kind of preparation method of antibacterial hydrogel dressing, carry out the following steps successively:

[0020] 1) 50g of double-ended hydroxyl polyethylene glycol (molecular weight is 2000) after azeotropic dewatering of toluene is dissolved in 200ml of dry tetrahydrofuran, and 25ml of acryloyl chloride is slowly added dropwise (15 drops / min) in an ice bath, After dropping, the ice bath was removed, and the reaction was carried out at room temperature for 8 h under nitrogen protection. The obtained reactant was filtered to remove the solid to obtain a clear liquid; the clear liquid was evaporated to dryness at 60° C. to obtain a crude product. The crude product was washed three times with saturated sodium chloride solution (200ml×3), then dissolved in 100ml of dichloromethane, placed in a nitrogen blower (Hangzhou Aosheng Instrument Co., Ltd.) to concentrate the organic phase, and the solution volume was reduced to the original. 40% of the volume; ...

Embodiment 2

[0023] Example 2, a preparation method of an antibacterial hydrogel dressing, changing the collagen in step 2) of Example 1 into dextran; obtaining a dextran aqueous solution containing nano-Ag; The collagen aqueous solution was changed to dextran aqueous solution, and the irradiation dose was changed to 40KGy; the rest were the same as in Example 1.

[0024] Antibacterial hydrogel dressings with a thickness of 0.5 mm and a solid content of 25.0% were obtained by polymerization in a mold.

Embodiment 3

[0025] Example 3. A method for preparing an antibacterial hydrogel dressing. The collagen in step 2) of Example 1 was changed to hyaluronic acid; a hyaluronic acid aqueous solution containing nano-Ag was obtained; the collagen in step 3) of Example 1 was changed into The aqueous solution was changed to hyaluronic acid aqueous solution, and the irradiation dose was changed to 80KGy; the rest were the same as in Example 1.

[0026] The antibacterial hydrogel dressing with a thickness of 0.5 mm and a solid content of 33.8% was obtained by polymerization in a mold.

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Abstract

The invention discloses a preparation method of anti-bacterial hydrogel dressing. The method comprises the following steps: 1) dissolving dihydroxy-terminated polyethylene glycol in tetrahydrofuran, adding acryloyl chloride to react at room temperature under the protection of nitrogen, treating the obtained reaction product through filtrating, evaporating, washing and concentrating to obtain polyethyleneglycol diacrylate crosslinking agent; 2) using ZnO nanoparticles containing Ag<+> to prepare 15-30wt% of nanometer water solution, then dissolving natural high molecular material in the nanometer water solution to obtain natural high molecular water solution containing nano-Ag; 3) mixing acrylamide, polyethyleneglycol and natural high molecular water solution containing nano-Ag, placing the mixture at room temperature under the irradiation of <60>Co source for crosslinking and obtaining the anti-bacterial hydrogel dressing, the molar ratio of Ag to Zn is 1:4. The anti-bacterial hydrogel dressing prepared by the method is a kind of porous reticular dressing with antibacterial property and hydrating capacity.

Description

technical field [0001] The invention belongs to the technical field of medical wound repair material manufacturing, in particular to a preparation method of a porous mesh dressing with antibacterial properties and hydration properties, which is formed by cross-linking synthetic polymers and natural polymers by irradiation technology. Background technique [0002] The skin is the largest organ of the human body and a natural barrier between the human body and the outside world; however, the large area of ​​exposure to the outside world makes the skin vulnerable to external injuries such as burns and mechanical injuries. my country has a large population base, and there are nearly one million patients with severe burns and scalds every year. Not only that, but also large-scale skin ulcers caused by complications of many chronic diseases, such as diabetes, phlebitis, and bedsores, are becoming more and more common in my country. Due to the lack of self-regeneration ability, all ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/32A61L15/28A61L15/46A61L15/62A61L15/42
Inventor 余志扬宋伟杰仇建峰
Owner 绍兴锐创生物科技有限公司
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