Injection type skin filling composition as well as preparation method and application thereof

A composition and polymer technology, applied in the field of medicine, can solve the problems of insignificant immediate filling effect, poor dispersibility of PLA particles, and gel shift of polycaprolactone, and achieve controllable degradation time, narrow particle size distribution, Reduces subcutaneous nodules, redness, etc.

Active Publication Date: 2022-03-01
SICHUAN SINCO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the fillers with immediate filling combined with long-term restoration are mainly polylactic acid freeze-dried powder and polycaprolactone gel. However, polylactic acid freeze-dried injection products have cumbersome reconstitution operations, and PLA particles have poor dispersion and are easy to reconstitute after reconstitution. Aggregation and deposition, resulting in easy blockage of the needle during intradermal injection, prone to subcutaneous nodules after injection, thicker needles used for injection, resulting in increased pain for patients, and immediate filling effect is not obvious, etc.
Migration issues with polycaprolactone gels

Method used

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  • Injection type skin filling composition as well as preparation method and application thereof
  • Injection type skin filling composition as well as preparation method and application thereof
  • Injection type skin filling composition as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0048] This experimental example provides a kind of preparation method of the composition of the present invention, specifically comprises the following steps:

[0049] Using tetrahydrofuran and dichloromethane as solvents (the volume ratio of the two solvents is 2:8), mix them with polycaprolactone (viscosity 1.2dl / g) to prepare an oil phase, wherein the mass fraction of polycaprolactone is 10% .

[0050] Add polyvinyl alcohol (viscosity 25mPa·s) and Tween-80 as solutes (the mass ratio of the two solutes is 9.5:0.5), add pure water, and configure an aqueous phase, wherein the solute mass fraction is 1%.

[0051] The volume ratio of oil phase to water phase is 1:5.

[0052] Preparation of microspheres by shear emulsification method: the specific parameter of mechanical stirring is 1000r / min, the oil phase is added dropwise in the water phase ice bath (5-8°C) and stirring is turned on, stirring and emulsifying for 30min, and then in Reduce the rotation speed at 5-8°C and cont...

Embodiment 2

[0060] This embodiment provides a preparation method of the composition of the present invention, which specifically includes the following steps:

[0061] Step 1: Preparation of microspheres

[0062] Using tetrahydrofuran and dichloromethane as solvents (the volume ratio of the two solvents is 2:8), mix them with polycaprolactone (viscosity 1.2dl / g) to prepare an oil phase, wherein the mass fraction of polycaprolactone is 10% .

[0063] Add polyvinyl alcohol (viscosity 25 mPa·s) and Tween-80 as solutes (the mass ratio of the two solutes is 9.5:0.5), add pure water, and configure an aqueous phase, wherein the solute mass fraction is 1%.

[0064] The volume ratio of oil phase to water phase is 1:5.

[0065] Preparation of microspheres by membrane emulsification method: the oil phase is passed through the SPG membrane (pore size is 10 μm) at a pressure of 0.2 kPa, and mixed with the water phase (under ice bath conditions of 5-8 °C) under stirring, and the stirring rate is 250...

Embodiment 3

[0073] This embodiment provides a preparation method of the composition of the present invention, which specifically includes the following steps:

[0074] Step 1: Preparation of microspheres

[0075] Using tetrahydrofuran and dichloromethane as solvents (the volume ratio of the two solvents is 1:9), mix them with polycaprolactone (viscosity 1.2dl / g) to prepare an oil phase, wherein the mass fraction of polycaprolactone is 10% .

[0076] Preparation of microspheres by spray drying method: put the oil phase into the spray drying equipment, and the specific setting parameters are: the inlet temperature is 65°C, the outlet temperature is 40°C, the feed rate is 10ml / min, and the high-pressure air flow rate is 400L / h . The particle size range of the obtained microspheres is 20-60 μm.

[0077] The microspheres obtained above were sieved to obtain microspheres with a particle size of 25-40 μm (accounting for 65.2% by mass of the total microspheres).

[0078] Step 2: Preparation o...

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Abstract

The invention relates to the technical field of medicines, and particularly discloses an injection type skin filling composition as well as a preparation method and application thereof. The composition comprises polymer microspheres, a polyethylene glycol derivative and dispersion liquid, the polymer microspheres are polycaprolactone microspheres, the polyethylene glycol derivative is polyethylene glycol-succinimide succinate or polyethylene glycol-succinimide glutaric acid ester, and the dispersion liquid is a polycaprolactone microsphere. The dispersion liquid is prepared from oligopeptide acetate and sodium carboxymethyl cellulose. The composition can achieve the effects of precise targeted positioning and occupied filling at the action position, has no swelling displacement risk, can achieve the targeted immediate filling effect, is high in biocompatibility and good in resolubility, can reduce the inflammatory reaction after material implantation, and is safe and effective in clinical application.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an injectable dermal filling composition and its preparation method and application. Background technique [0002] Injectable dermal filler is one of the non-surgical medical aesthetic projects. It has the advantages of minimally invasive, immediate filling and long-lasting repair. It is a key direction for the development of light medical beauty. The proportion of the overall medical beauty market has steadily increased. [0003] At present, the facial fillers on the market mainly include autologous fat, collagen, hyaluronic acid, PMMA, polylactic acid, polycaprolactone, etc. Afterwards, it only plays the role of physical filling and will be absorbed by the body soon. In order to maintain the filling effect, repeated injections are required in a short time. PMMA material is a permanently filled, non-degradable material, so there are safety concerns. [0004] The latest gener...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/50A61L27/18A61L27/16A61L27/20
CPCA61L27/50A61L27/18A61L27/16A61L27/20A61L2400/06C08L67/04C08L29/04C08L71/02C08L1/286
Inventor 冷鸿飞徐小雨吴鸣陶秀梅
Owner SICHUAN SINCO PHARMA
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