Preparation of absorbable medical membrane

A technology based on lactic acid and polyethylene glycol, applied in absorbent pads, medical science, bandages, etc., can solve the problems of unsatisfactory flexibility and uncontrollable degradation time of biodegradable materials, and achieve reliable in vivo degradation, low production cost, Good biocompatibility effect

Inactive Publication Date: 2008-10-01
上海致远生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to overcome the technical problems that the flexibility of the existing lactic acid / polyethylene glycol copolymer biodegradable materials is not ideal, and the degradation time cannot be controlled, and provide people with a simple process, stable quality, and adjustable degradation time. Preparation method of absorbable medical film with better flexibility and stretchability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] React poly-DL-lactic acid with an intrinsic viscosity of 0.2-15 grams and a molecular weight of polyethylene glycol of 2000-8000 95 grams at 95°C for 10 hours to obtain poly-DL-lactic acid / polyethylene glycol Copolymer biodegradable material.

[0021] Dissolve the poly-DL-lactic acid / polyethylene glycol copolymer completely with 200 grams of mixed solvent at 40°C, pour the poly-DL-lactic acid / polyethylene glycol copolymer solution into a film-making mold, and place it at room temperature for 3 hours. Vacuum dry at 40°C to constant weight to obtain the primary film; Stretch the primary film at 30°C by 120% (based on the original length of the primary film), heat-set at 60°C for 2 hours, Under the condition of vacuum drying for 12 hours, the absorbable medical film can be obtained; wherein, the mixed solvent is acetone: ethyl acetate: tetrahydrofuran: chloroform = 10%: 8%: 2%: 80% (weight ratio).

Embodiment 2

[0023] React 0.5 g of poly-DL-lactic acid with an intrinsic viscosity of 0.2 to 199.5 grams and a molecular weight of polyethylene glycol of 2000 to 8000 at 220°C for 1 hour to obtain poly-DL-lactic acid / polyethylene glycol Copolymer biodegradable material.

[0024] Dissolve the poly-DL-lactic acid / polyethylene glycol copolymer completely with 2000 grams of mixed solvent at 40°C, pour the poly-DL-lactic acid / polyethylene glycol copolymer solution into the film-making mold, and leave it at room temperature for 5 hours , vacuum-dried at 60°C to constant weight to obtain the first product film; the first product film was stretched at 50°C by 10% (based on the original length of the first product film), and after heat setting at 80°C for 1 hour, Vacuum drying at room temperature for 12 hours to obtain an absorbable medical film; wherein, the mixed solvent is acetone: ethyl acetate: tetrahydrofuran: chloroform = 90%: 8%: 2%: 0 (weight ratio).

Embodiment 3

[0026] Poly-DL-lactic acid, whose intrinsic viscosity is 0.2-150 grams, and the molecular weight of polyethylene glycol is 2000-8000 50 grams, reacted at 150 ° C for 3 hours to obtain poly-DL-lactic acid / polyethylene glycol Copolymer biodegradable material.

[0027] Dissolve the poly-DL-lactic acid / polyethylene glycol copolymer completely with 1000 grams of mixed solvent at 40°C, pour the poly-DL-lactic acid / polyethylene glycol copolymer solution into the film-making mold, and place it at room temperature for 4 hours , vacuum-dried at 50°C to constant weight to obtain the first product film; the first product film was stretched at 40°C by 60% (based on the original length of the first product film), and after heat setting at 70°C for 2 hours, Vacuum drying at room temperature for 12 hours to obtain an absorbable medical film; wherein, the mixed solvent is acetone: ethyl acetate: tetrahydrofuran: chloroform = 10%: 88%: 2%: 0 (weight ratio).

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PUM

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Abstract

The invention pertains to the field of preparation of medical supplies, in particular to a preparation method of a medical absorbable membrane. In the method, lactic acid and polyethylene glycol are copolymerized by a method of bulk polymerization so as to obtain the medical absorbable membrane of lactic acid/polyethylene glycol copolymer. The preparation method is characterized in that the lactic acid is poly-DL-lactic acid, the limiting viscosity number of which is 0.2 to 1; the molecular weight of polyethylene glycol is 2000 to 8000 and the proportion of each component is poly-DL-lactic acid of 1 to 99.5 percent and 0.5 to 99 percent of polyethylene glycol; the reaction temperature is 100 to 280 DEG C and the reaction time is 2 to 12 hours. The preparation method of the invention has simple process and low production cost and by adopting the preparation method, the medical absorbable membrane have the advantages of uniform thickness, stable quality, good biocompatibility and reliable degradation in human body and being capable of preventing adhesion caused in the surgical operation.

Description

Technical field: [0001] The invention belongs to the field of preparation of medical supplies, and in particular relates to a preparation method of an absorbable medical film. Background technique: [0002] In existing surgical operations, an anti-adhesion film is often used as a physical barrier to prevent postoperative adhesions. General anti-adhesion films are bioabsorbable medical films, such as polylactic acid film, hyaluronic acid film, chitosan film and so on. Commercially available polylactic acid films are polylactic acid-glycolic acid copolymers or polylactic acid homopolymer films, which are brittle, poor in flexibility and stretchability, and take too long to degrade, which has certain disadvantages in use and safety. However, the degradation time of hyaluronic acid film, chitosan film and oxidized cellulose film is too short to maintain the function of physical barrier within the required time, and cannot better complete the anti-adhesion function. In addition,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/26
Inventor 肖凡
Owner 上海致远生物科技有限公司
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