Polylactic acid degradable film

Abstract

The invention relates to a polylactic acid degradable film with controllable degradable time, belonging to the technical field of medical appliances. The polylactic acid degradable film comprises the following components in percentage by weight: 1%-35% of plasticizer and 65%-99% of polylactic acid, polylactic acid-glycollic acid copolymer, polyglycollic acid-epsilon-caprolactone copolymer, polylactic acid-epsilon-caprolactone copolymer or polylactic acid-glycollic acid-epsilon-caprolactone copolymer, wherein the plasticizer is more than one of citrate ether, glucose monoester ether, fatty acid ester ether, polyethylene glycol 400-2,000, low-molecular weight polylactic acid, glycerol, glycerol triacetate and ethylene glycol monobutyl ether acetate. The manufactured polylactic acid degradable film of the invention has good strength and controllable degradable time, can be used for a human body, such as an anti-adhesion film in a surgical operation, a digestive stent, a biliary stent, a prostate stent, an endovascular stent, an intrauterine stent and a medical appliance fitting, and can be used for preparing the required controllable polylactic acid degradable film according to the clinical requirements.

Description

technical field

[0001] The invention relates to a polylactic acid degradation film, in particular to a polylactic acid degradation film with controllable degradation time, belonging to the technical field of medical devices. Background technique

[0002] Polylactic acid is a non-toxic and non-irritating polymer material, which has excellent biocompatibility, bioabsorbability, high mechanical strength and processability, and has gradually become an important medical polymer material. Has broad development prospects. As an important biodegradable polymer material, it has been approved by the US FDA. At present, polylactic acid and its copolymers have been applied in many medical fields, such as: bone fixation materials, surgical sutures, and surgical anti-adhesion films. , cell membrane structures, artificial ligaments or tendons, artificial blood vessels, tissue engineering scaffold materials, drug release systems, ophthalmic implant materials, medical accessories, etc. [...