Polylactic acid degradable film

A polylactic acid and degradable film technology, which is applied in the field of medical devices, can solve the problems such as the controllable degradation time performance needs to be further improved, and achieve the effect of controllable degradation time and good strength.

Inactive Publication Date: 2010-07-07
山东省医疗器械研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such as the two polylactic acid films disclosed in the application numbers 200610020499 and 03117428, but the controllable performance of their degradation time needs to be further improved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Get 95% by weight polylactic acid and glycolic acid copolymer PLGA (75 / 25, molecular weight is 800,000), and 5% by weight ethylene glycol butyl ether acetate, heat and melt at 185 ° C, and then banbury Mix well in the machine, place the material between two layers of polyester film after discharge, put it into the mold of a flat vulcanizer, heat and pressurize, and prepare a 0.2mm film.

Embodiment 2

[0017] Get 85% polylactic acid PLLA (molecular weight is 50,000), the weight percentage is 15% glyceryl triacetate, dissolve with co-solvent dichloromethane, be mixed with polyglycolic acid mass concentration and be 10% solution, place Stir regularly for 24 hours to make it fully mixed evenly, then pour it into a horizontal film cavity, control the temperature and humidity, and completely evaporate the solvent to obtain a 0.2mm film.

Embodiment 3

[0019] Get 75% polylactic acid PLLA (molecular weight is 500,000), 20% by weight of laureth-6 citrate, 5% by weight of polyethylene glycol PEG1000, in a molten state at 185 ° C Mix evenly in the internal mixer, put the material between two layers of polyester film after discharge, put it in the mold of a flat vulcanizer, heat and pressurize, and prepare a 0.2mm film.

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PUM

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Abstract

The invention relates to a polylactic acid degradable film with controllable degradable time, belonging to the technical field of medical appliances. The polylactic acid degradable film comprises the following components in percentage by weight: 1%-35% of plasticizer and 65%-99% of polylactic acid, polylactic acid-glycollic acid copolymer, polyglycollic acid-epsilon-caprolactone copolymer, polylactic acid-epsilon-caprolactone copolymer or polylactic acid-glycollic acid-epsilon-caprolactone copolymer, wherein the plasticizer is more than one of citrate ether, glucose monoester ether, fatty acid ester ether, polyethylene glycol 400-2,000, low-molecular weight polylactic acid, glycerol, glycerol triacetate and ethylene glycol monobutyl ether acetate. The manufactured polylactic acid degradable film of the invention has good strength and controllable degradable time, can be used for a human body, such as an anti-adhesion film in a surgical operation, a digestive stent, a biliary stent, a prostate stent, an endovascular stent, an intrauterine stent and a medical appliance fitting, and can be used for preparing the required controllable polylactic acid degradable film according to the clinical requirements.

Description

technical field [0001] The invention relates to a polylactic acid degradation film, in particular to a polylactic acid degradation film with controllable degradation time, belonging to the technical field of medical devices. Background technique [0002] Polylactic acid is a non-toxic and non-irritating polymer material, which has excellent biocompatibility, bioabsorbability, high mechanical strength and processability, and has gradually become an important medical polymer material. Has broad development prospects. As an important biodegradable polymer material, it has been approved by the US FDA. At present, polylactic acid and its copolymers have been applied in many medical fields, such as: bone fixation materials, surgical sutures, and surgical anti-adhesion films. , cell membrane structures, artificial ligaments or tendons, artificial blood vessels, tissue engineering scaffold materials, drug release systems, ophthalmic implant materials, medical accessories, etc. [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L67/04C08K5/101C08K5/103C08K5/11C08L71/08C08L71/02
Inventor 李俊起刘吉勇王传栋刘阳李红梅
Owner 山东省医疗器械研究所
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